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. 1982 Oct;35(10):1118–1121. doi: 10.1136/jcp.35.10.1118

Antinuclear antibody-negative systemic lupus erythematosus-how common?

K C McHardy, C H Horne, J Rennie
PMCID: PMC497894  PMID: 6982285

Abstract

A review of five years' DNA-binding antibody results in a routine service laboratory revealed 38 patients who had high DNA-binding capacity (DNA-bc) but no antinuclear antibodies (ANA). On retrospective case note analysis, 22 patients (58%) were thought to have systemic lupus erythematosus (SLE), although only six (16%) fulfilled the preliminary classification criteria of the American Rheumatism Association (ARA). Our findings indicate that ANA-negative SLE is commoner than generally realised and lead us to recommended the measurement of DNA-bc in every case where clinically appropriate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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