Abstract
An abnormal and transient increase of the Coulter mean red cell volume (MCV) was observed in four of 10 patients with diabetic decompensation. A sequential study of haematological and biochemical measurements in these patients revealed that this phenomenon was associated with the hyperosmolar state. The proposed mechanism and the clinical implications of this change are briefly discussed.
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Selected References
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- Beautyman W., Bills T. Letter: Osmotic error in measurements of red-cell volume. Lancet. 1974 Oct 12;2(7885):905–906. doi: 10.1016/s0140-6736(74)91246-x. [DOI] [PubMed] [Google Scholar]
- Chalmers D. M., Levi A. J., Chanarin I., North W. R., Meade T. W. Mean cell volume in a working population: the effects of age, smoking, alcohol and oral contraception. Br J Haematol. 1979 Dec;43(4):631–636. doi: 10.1111/j.1365-2141.1979.tb03796.x. [DOI] [PubMed] [Google Scholar]
- Cooper R. A. Abnormalities of cell-membrane fluidity in the pathogenesis of disease. N Engl J Med. 1977 Aug 18;297(7):371–377. doi: 10.1056/NEJM197708182970707. [DOI] [PubMed] [Google Scholar]
- DITZEL J., SAGILD U. Morphologic and hemodynamic changes in the smaller blood vessels in diabetes mellitus. II. The degenerative and hemodynamic changes in the bulbar conjunctiva of normotensive diabetic patients. N Engl J Med. 1954 Apr 8;250(14):587–594. doi: 10.1056/NEJM195404082501401. [DOI] [PubMed] [Google Scholar]
- Davidson R. J., Evan-Wong L. A., Lean M. E. The Coulter MCV in diabetic ketoacidosis. Clin Lab Haematol. 1981;3(1):90–91. [PubMed] [Google Scholar]
- Legge D. G., Shortman K. The effect of pH on the volume, density and shape of erythrocytes and thymic lymphocytes. Br J Haematol. 1968 Mar;14(3):323–335. doi: 10.1111/j.1365-2141.1968.tb01503.x. [DOI] [PubMed] [Google Scholar]
- NEVIUS D. B. Osmotic error in electronic determinations of red cell volume. Am J Clin Pathol. 1963 Jan;39:38–41. doi: 10.1093/ajcp/39.1.38. [DOI] [PubMed] [Google Scholar]
- Schmid-Schönbein H., Volger E. Red-cell aggregation and red-cell deformability in diabetes. Diabetes. 1976;25(2 Suppl):897–902. [PubMed] [Google Scholar]
- Ur A., Lushbaugh C. C. Some effects of electrical fields on red blood cells with remarks on electronic red cell sizing. Br J Haematol. 1968 Dec;15(6):527–538. doi: 10.1111/j.1365-2141.1968.tb01575.x. [DOI] [PubMed] [Google Scholar]