Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Jun;36(6):683–692. doi: 10.1136/jcp.36.6.683

Problems of infection after bone marrow transplantation.

J G Watson
PMCID: PMC498351  PMID: 6304151

Abstract

Representatives of 17 bone marrow transplant (BMT) teams met to discuss the problems of infection after BMT. With experience of more than 2200 transplanted patients over the past 10 yr, the changes in the patterns of infection were surprisingly similar. Deaths due purely to bacterial infection have greatly diminished and the major early problems today result from fungi and cytomegalovirus. The role of non-herpes group viruses has only recently received attention. With increasing numbers of survivors, late bacterial infections are assuming importance. The meeting also provided an opportunity to document the measures adopted to prevent infection during BMT and following discharge.

Full text

PDF
692

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bortin M. M., Kay H. E., Gale R. P., Rimm A. A. Factors associated with interstitial pneumonitis after bone-marrow transplantation for acute leukaemia. Lancet. 1982 Feb 20;1(8269):437–439. doi: 10.1016/s0140-6736(82)91633-6. [DOI] [PubMed] [Google Scholar]
  2. Burns W. H., Saral R., Santos G. W., Laskin O. L., Lietman P. S., McLaren C., Barry D. W. Isolation and characterisation of resistant Herpes simplex virus after acyclovir therapy. Lancet. 1982 Feb 20;1(8269):421–423. doi: 10.1016/s0140-6736(82)91620-8. [DOI] [PubMed] [Google Scholar]
  3. Hann I. M., Prentice H. G., Corringham R., Blacklock H. A., Keaney M., Shannon M., Noone P., Gascoigne E., Fox J., Boesen E. Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients. Lancet. 1982 Apr 10;1(8276):826–829. doi: 10.1016/s0140-6736(82)91874-8. [DOI] [PubMed] [Google Scholar]
  4. Heidt P. J., Wagemaker G., Knaan-Shanzer S., van Bekkum D. W. Two distinct types of late onset graft-versus-host disease after bone marrow transplantation in lethally irradiated mice. Transplantation. 1981 Sep;32(3):263–264. [PubMed] [Google Scholar]
  5. Joss D. V., Barrett A. J., Kendra J. R., Lucas C. F., Desai S. Hypertension and convulsions in children receiving cyclosporin A. Lancet. 1982 Apr 17;1(8277):906–906. doi: 10.1016/s0140-6736(82)92171-7. [DOI] [PubMed] [Google Scholar]
  6. O'Reilly R. J., Lee F. K., Grossbard E., Kapoor N., Kirkpatrick D., Dinsmore R., Stutzer C., Shah K. V., Nahmias A. J. Papovavirus excretion following marrow transplantation: incidence and association with hepatic dysfunction. Transplant Proc. 1981 Mar;13(1 Pt 1):262–266. [PubMed] [Google Scholar]
  7. Quinnan G. V., Jr, Kirmani N., Rook A. H., Manischewitz J. F., Jackson L., Moreschi G., Santos G. W., Saral R., Burns W. H. Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N Engl J Med. 1982 Jul 1;307(1):7–13. doi: 10.1056/NEJM198207013070102. [DOI] [PubMed] [Google Scholar]
  8. Selby P. J., Powles R. L., Janeson B., Kay H. E., Watson J. G., Thornton R., Morgenstern G., Clink H. M., McElwain T. J., Prentice H. G. Parenteral acyclovir therapy for herpesvirus infections in man. Lancet. 1979 Dec 15;2(8155):1267–1270. doi: 10.1016/s0140-6736(79)92281-5. [DOI] [PubMed] [Google Scholar]
  9. Winston D. J., Ho W. G., Howell C. L., Miller M. J., Mickey R., Martin W. J., Lin C. H., Gale R. P. Cytomegalovirus infections associated with leukocyte transfusions. Ann Intern Med. 1980 Nov;93(5):671–675. doi: 10.7326/0003-4819-93-5-671. [DOI] [PubMed] [Google Scholar]
  10. Winston D. J., Pollard R. B., Ho W. G., Gallagher J. G., Rasmussen L. E., Huang S. N., Lin C. H., Gossett T. G., Merigan T. C., Gale R. P. Cytomegalovirus immune plasma in bone marrow transplant recipients. Ann Intern Med. 1982 Jul;97(1):11–18. doi: 10.7326/0003-4819-97-1-11. [DOI] [PubMed] [Google Scholar]
  11. van Bekkum D. W. Bone marrow transplantation. Transplant Proc. 1977 Mar;9(1):147–154. [PubMed] [Google Scholar]
  12. van Bekkum D. W., Knaan S. Role of bacterial microflora in development of intestinal lesions from graft-versus-host reaction. J Natl Cancer Inst. 1977 Mar;58(3):787–790. doi: 10.1093/jnci/58.3.787. [DOI] [PubMed] [Google Scholar]
  13. van Bekkum D. W., Roodenburg J., Heidt P. J., van der Waaij D. Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora. J Natl Cancer Inst. 1974 Feb;52(2):401–404. doi: 10.1093/jnci/52.2.401. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES