The authors found that there is an error in the absolute stereochemistry of 5 e in Figure 1. The authors showed (R)‐5 e, but is should be (S)‐5 e. The correct Figure 1 is shown, and the corresponding sentence (page 235, line 8, second column), should read:
Figure 1.
X‐ray crystallographic structure of (S)‐5 e (CCDC 1009021).
“The absolute configuration of 5 e was determined as S by X‐ray crystallography (Figure 1), and the stereochemistry of 5 a–d, 5 f–i was tentatively assigned by analogy.”
Based on this correction, the stereochemistry of compounds 5 in Scheme 1, Table 3, and Scheme 1, 1, 2 should be corrected as follows (corrections are shown in red):
Scheme 1.
Electrophilic pentafluorophenylation by 1 and transformations to chiral α‐pentafluorophenyl ketones having an all‐carbon stereocenter.
Table 1.
Creation of an all‐carbon stereogenic center with C6F5: asymmetric alkylation of α‐pentafluorophenyl ketones 4 with R−Br under organocatalysis.[a]
| ||||||
|---|---|---|---|---|---|---|
| Entry | 4, n | R | Time [h] | 5 | Yield[b] [%] | ee [c] [%] |
| 1[d] | 4 a, n=1 | allyl | 96 | 5 a | 95 | 87 (−) |
| 2 | 4 a, n=1 | benzyl | 24 | 5 b | 95 | 96 (+) |
| 3 | 4 a, n=1 | CH2‐p‐Tol | 48 | 5 c | 91 | 96 (−) |
| 4[e] | 4 a, n=1 | CH2‐p‐MeOPh | 72 | 5 d | 84 | 95 (−) |
| 5 | 4 a, n=1 | CH2‐p‐BrPh | 48 | 5 e | 87 | 98 (−) |
| 6 | 4 a, n=1 | CH2‐1‐Naphthyl | 96 | 5 f | 83 | 92 (+) |
| 7 | 4 a, n=1 | CH2‐2‐Naphthyl | 24 | 5 g | 89 | 94 (−) |
| 8 | 4 b, n=2 | benzyl | 48 | 5 h | 93 | 96 (−) |
[a] Reagents and conditions: a) R−Br (2.0 equiv), 7 (10 mol %), aq KOH (50 wt %), toluene, −40 °C, time. All reactions were carried out using 7 a as a catalyst unless noted otherwise. [b] Isolated yield. [c] Determined by HPLC analysis. [d] Catalyst 7 b was used instead of 7 a. [e] R−Br (1.2 equiv) was employed.
Scheme 2.
Creation of an all‐carbon stereogenic center with C6F5: palladium‐catalyzedasymmetric decarboxylative allylation of 3 d and 3 o using the Trost ligand.
This correction does not influence any of the data presented in the article, nor its interpretation. The authors apologize for these mistakes.