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. 1983 Oct;36(10):1140–1144. doi: 10.1136/jcp.36.10.1140

Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.

S J Machin, J P Keenan, B A McVerry
PMCID: PMC498490  PMID: 6413552

Abstract

A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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