Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Nov;36(11):1292–1297. doi: 10.1136/jcp.36.11.1292

The pathology of meconium ileus equivalent.

I Jeffrey, D Durrans, M Wells, H Fox
PMCID: PMC498548  PMID: 6630579

Abstract

A case of meconium ileus equivalent in a 25-year-old woman with cystic fibrosis is reported and the pathology of this condition is described. On gross examination the lumen of the terminal ileum was completely obstructed by a mass of inspissated faecal material with a putty-like consistency. The principal microscopic findings were plugging of the mucosal crypts with mucoid secretion, distention of goblet cells and the presence of a thick layer of mucus, admixed with faecal material, adherent to the mucosal surface. Mucin histochemistry demonstrated sulphomucin in the terminal ileum, although acidic mucins in the normal small intestine are almost exclusively non-sulphated.

Full text

PDF
1293

Images in this article

1293Image
on p.1293
1293Image
on p.1293
1294Image
on p.1294
1294Image
on p.1294
1295Image
on p.1295
1295Image
on p.1295

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLANC W. A., REID J. D., ANDERSEN D. H. Avitaminosis E in cystic fibrosis of the pancreas: a morphologic study of gastrointestinal and striated muscle. Pediatrics. 1958 Sep;22(3):494–506. [PubMed] [Google Scholar]
  2. Berk R. N., Lee F. A. The late gastrointestinal manifestations of cystic fibrosis of the pancreas. Radiology. 1973 Feb;106(2):377–381. doi: 10.1148/106.2.377. [DOI] [PubMed] [Google Scholar]
  3. Culling C. F., Reid P. E., Clay M. G., Dunn W. L. The histochemical demonstration of O-acylated sialic acid in gastrointestinal mucins. Their association with the potassium hydroxide-periodic acid-schiff effect. J Histochem Cytochem. 1974 Aug;22(8):826–831. doi: 10.1177/22.8.826. [DOI] [PubMed] [Google Scholar]
  4. Culling C. F., Reid P. E., Dunn W. L. The effect of saponification upon certain histochemical reactions of the epithelial mucins of the gastrointestinal tract. J Histochem Cytochem. 1971 Nov;19(11):654–662. doi: 10.1177/19.11.654. [DOI] [PubMed] [Google Scholar]
  5. HALLBERG D. MUCOVISCIDOSIS ILEUS. Acta Chir Scand. 1964 Aug;128:201–209. [PubMed] [Google Scholar]
  6. Hage E., Andersen F. U. Light and electron microscopical studies of rectal biopsies in cystic fibrosis. Acta Pathol Microbiol Scand A. 1972;80(3):345–350. doi: 10.1111/j.1699-0463.1972.tb00289.x. [DOI] [PubMed] [Google Scholar]
  7. Kopel F. B. Gastrointestinal manifestations of cystic fibrosis. Gastroenterology. 1972 Mar;62(3):483–491. [PubMed] [Google Scholar]
  8. MULLINS F., TALAMO R., DISANTAGNESE P. A. LATE INTESTINAL COMPLICATIONS OF CYSTIC FIBROSIS. JAMA. 1965 May 31;192:741–746. doi: 10.1001/jama.1965.03080220005001. [DOI] [PubMed] [Google Scholar]
  9. Matsehe J. W., Go V. L., DiMagno E. P. Meconium ileus equivalent complicating cystic fibrosis in postneonatal children and young adults. Report of 12 cases. Gastroenterology. 1977 Apr;72(4 Pt 1):732–736. [PubMed] [Google Scholar]
  10. Matsehe J. W., Go V. L., DiMagno E. P. Meconium ileus equivalent complicating cystic fibrosis in postneonatal children and young adults. Report of 12 cases. Gastroenterology. 1977 Apr;72(4 Pt 1):732–736. [PubMed] [Google Scholar]
  11. Morrissey S. M., Tymvios M. C. Acid mucins in human intestinal goblet cells. J Pathol. 1978 Dec;126(4):197–208. doi: 10.1002/path.1711260403. [DOI] [PubMed] [Google Scholar]
  12. Oppenheimer E. H., Esterly J. R. Cystic fibrosis of the pancreas. Morphologic findings in infants with and without diagnostic pancreatic lesions. Arch Pathol. 1973 Sep;96(3):149–154. [PubMed] [Google Scholar]
  13. Oppenheimer E. H., Esterly J. R. Pathology of cystic fibrosis review of the literature and comparison with 146 autopsied cases. Perspect Pediatr Pathol. 1975;2:241–278. [PubMed] [Google Scholar]
  14. PARKINS R. A., EIDELMAN S., RUBIN C. E., DOBBINS W. O., 3rd, PHELPS P. C. THE DIAGNOSIS OF CYSTIC FIBROSIS BY RECTAL SUCTION BIOPSY. Lancet. 1963 Oct 26;2(7313):851–856. doi: 10.1016/s0140-6736(63)92744-2. [DOI] [PubMed] [Google Scholar]
  15. SNYDER W. H., Jr, GWINN J. L., LANDING B. H., ASAY L. D. FECAL RETENTION IN CHILDREN WITH CYSTIC FIBROSIS. REPORT OF THREE CASES. Pediatrics. 1964 Jul;34:72–77. [PubMed] [Google Scholar]
  16. SPICER S. S. DIAMINE METHODS FOR DIFFERENTIALING MUCOSUBSTANCES HISTOCHEMICALLY. J Histochem Cytochem. 1965 Mar;13:211–234. doi: 10.1177/13.3.211. [DOI] [PubMed] [Google Scholar]
  17. Sheahan D. G., Jervis H. R. Comparative histochemistry of gastrointestinal mucosubstances. Am J Anat. 1976 Jun;146(2):103–131. doi: 10.1002/aja.1001460202. [DOI] [PubMed] [Google Scholar]
  18. Shwachman H., Holsclaw D. Examination of the appendix at laparotomy as a diagnostic clue in cystic fibrosis. N Engl J Med. 1972 Jun 15;286(24):1300–1301. doi: 10.1056/NEJM197206152862405. [DOI] [PubMed] [Google Scholar]
  19. Shwachman H., Kowalski M., Khaw K. T. Cystic fibrosis: a new outlook. 70 patients above 25 years of age. Medicine (Baltimore) 1977 Mar;56(2):129–149. [PubMed] [Google Scholar]
  20. Wesley A. W., Qureshi A. R., Forstner G. G., Forstner J. F. Differences in mucus glycoproteins of small intestine from subjects with and without cystic fibrosis. Adv Exp Med Biol. 1982;144:145–146. doi: 10.1007/978-1-4615-9254-9_19. [DOI] [PubMed] [Google Scholar]
  21. di Sant'agnese P. A., Davis P. B. Cystic fibrosis in adults. 75 cases and a review of 232 cases in the literature. Am J Med. 1979 Jan;66(1):121–132. doi: 10.1016/0002-9343(79)90491-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES