Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1984 Mar;37(3):307–312. doi: 10.1136/jcp.37.3.307

Increased angiotensin-converting enzyme activities in diabetes mellitus: analysis of diabetes type, state of metabolic control and occurrence of diabetic vascular disease.

G Schernthaner, C Schwarzer, R Kuzmits, M M Müller, U Klemen, H Freyler
PMCID: PMC498705  PMID: 6321559

Abstract

Serum angiotensin-converting enzyme activities were measured in 41 type 1 diabetics (16.4 +/- 4.0 U/ml), in 40 type 2 diabetics (15.0 +/- 5.2 U/ml) and in 52 controls (13.0 +/- 2.7 U/ml, mean +/- SD). Twenty six (32%) of 81 patients presented with serum angiotensin-converting enzyme activities above the normal range. No relation between serum angiotensin-converting enzyme activities and the presence or lack of diabetic vascular diseases in type 1 and type 2 diabetics could be detected. No significant differences in serum angiotensin-converting enzyme activities were found when comparing various types of diabetic vascular disease (retinopathy, neuropathy, renal failure, arterial vascular disease, diabetic vascular disease, coronary artery disease). However, mean serum angiotensin-converting enzyme activities were significantly increased in diabetics with retinopathy when compared with controls (p less than 0.0005). Correlation between metabolic long term control as determined by measuring glycohaemoglobin (HbA1) concentrations and serum angiotensin-converting enzyme activities could not be established. Serum angiotensin-converting enzyme activities did not show any correlations with duration of diabetes, age or sex of patients. A representative number of diabetics (32%) showed elevated serum angiotensin-converting enzyme activities, but a correlation with diabetic vascular disease, metabolic control or type of disease could not be established.

Full text

PDF
310

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bing J., Poulsen K., Markussen J. The ability of various insulins and insulin fragments to inhibit the angiotensin I converting enzyme. Acta Pathol Microbiol Scand A. 1974 Nov;82(6):777–782. doi: 10.1111/j.1699-0463.1974.tb00405.x. [DOI] [PubMed] [Google Scholar]
  2. Borowsky S. A., Lieberman J., Strome S., Sastre A. Elevation of serum angiotensin-converting enzyme level. Occurrence in alcoholic liver disease. Arch Intern Med. 1982 May;142(5):893–895. [PubMed] [Google Scholar]
  3. DeRemee R. A., Rohrbach M. S. Serum angiotensin-converting enzyme activity in evaluating the clinical course of sarcoidosis. Ann Intern Med. 1980 Mar;92(3):361–365. doi: 10.7326/0003-4819-92-3-361. [DOI] [PubMed] [Google Scholar]
  4. Eschwege E., Guyot-Argenton C., Aubry J. P., Tchobroutsky G. Effect of multiple daily insulin injections on the course of diabetic retinopathy. Diabetes. 1976 May;25(5):463–469. [PubMed] [Google Scholar]
  5. Eschwege E., Job D., Guyot-Argenton C., Aubry J. P., Tchobroutsky G. Delayed progression of diabetic retinopathy by divided insulin administration: a further follow-up. Diabetologia. 1979 Jan;16(1):13–15. doi: 10.1007/BF00423144. [DOI] [PubMed] [Google Scholar]
  6. Ferlitsch A., Kummer F., Müller M. M., Legenstein E., Haber P., Kohoutt J. Angiotensin Converting Enzyme (ACE) Ein in vitro-Test für die Sarkoidose-Diagnostik. Klin Wochenschr. 1980 Feb 15;58(4):195–198. doi: 10.1007/BF01476778. [DOI] [PubMed] [Google Scholar]
  7. Grönhagen-Riska C., Kurppa K., Fyhrquist F., Selroos O. Angiotensin-converting enzyme and lysozyme in silicosis and asbestosis. Scand J Respir Dis. 1978 Aug;59(4):228–231. [PubMed] [Google Scholar]
  8. Lestradet H., Papoz L., Hellouin de Menibus C., Levavasseur F., Besse J., Billaud L., Battistelli F., Tric P., Lestradet F. Long-term study of mortality and vascular complications in juvenile-onset (type I) diabetes. Diabetes. 1981 Mar;30(3):175–179. doi: 10.2337/diab.30.3.175. [DOI] [PubMed] [Google Scholar]
  9. Lieberman J., Beutler E. Elevation of serum angiotensin-converting enzyme in Gaucher's disease. N Engl J Med. 1976 Jun 24;294(26):1442–1444. doi: 10.1056/NEJM197606242942609. [DOI] [PubMed] [Google Scholar]
  10. Lieberman J., Sastre A. Serum angiotensin-converting enzyme: elevations in diabetes mellitus. Ann Intern Med. 1980 Dec;93(6):825–826. doi: 10.7326/0003-4819-93-6-825. [DOI] [PubMed] [Google Scholar]
  11. Matsuki K., Sakata T. Angiotensin-converting enzyme in diseases of the liver. Am J Med. 1982 Oct;73(4):549–551. doi: 10.1016/0002-9343(82)90335-7. [DOI] [PubMed] [Google Scholar]
  12. Nakamura Y., Takeda T., Ishii M., Nishiyama K., Yamakada M., Hirata Y., Kimura K., Murao S. Elevation of serum angiotensin-converting enzyme activity in patients with hyperthyroidism. J Clin Endocrinol Metab. 1982 Nov;55(5):931–934. doi: 10.1210/jcem-55-5-931. [DOI] [PubMed] [Google Scholar]
  13. Overlack A., Higuchi M., Kolloch R., Stumpe K. O. Converting enzyme activity and essential hypertension. Klin Wochenschr. 1983 Apr 1;61(7):377–378. doi: 10.1007/BF01485031. [DOI] [PubMed] [Google Scholar]
  14. Schweisfurth H., Wernze H. Changes of serum angiotensin I converting enzyme in patients with viral hepatitis and liver cirrhosis. Acta Hepatogastroenterol (Stuttg) 1979 Jun;26(3):207–210. [PubMed] [Google Scholar]
  15. Shultz T., Miller W. C., Bedrossian C. W. Clinical application of measurement of angiotensin-converting enzyme level. JAMA. 1979 Aug 3;242(5):439–441. [PubMed] [Google Scholar]
  16. Studdy P., Bird R., James D. G. Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders. Lancet. 1978 Dec 23;2(8104-5):1331–1334. doi: 10.1016/s0140-6736(78)91972-4. [DOI] [PubMed] [Google Scholar]
  17. Tchobroutsky G. Relation of diabetic control to development of microvascular complications. Diabetologia. 1978 Sep;15(3):143–152. doi: 10.1007/BF00421230. [DOI] [PubMed] [Google Scholar]
  18. Welch S. G., Boucher B. J. A rapid micro-scale method for the measurement of Haemoglobin A1(a+b+c). Diabetologia. 1978 Mar;14(3):209–211. doi: 10.1007/BF00429782. [DOI] [PubMed] [Google Scholar]
  19. Yotsumoto H., Imai Y., Kuzuya N., Uchimura H., Matsuzaki F. Increased levels of serum angiotensin-converting enzyme activity in hyperthyroidism. Ann Intern Med. 1982 Mar;96(3):326–328. doi: 10.7326/0003-4819-96-3-326. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES