Abstract
Immunohistochemical procedures were used to analyse the subpopulations of mononuclear cells in muscle biopsies from 24 patients with polymyositis. The character of the cellular infiltrate was similar at the perivascular, perimysial, and endomysial sites, with cytotoxic-suppressor T lymphocytes (T8+) and macrophages being the dominant elements. Helper T lymphocytes (T4+) and B lymphocytes were present in smaller numbers. A control series of 17 muscle biopsies from normal subjects and patients with non-inflammatory myopathies and neurogenic conditions was also studied: the numbers of mononuclear cells present were much smaller than in polymyositis, but the ratio of T4:T8 lymphocytes was similar to that found in biopsies affected by polymyositis. We conclude that both cytotoxic-suppressor T lymphocytes and macrophages are important in the pathogenesis of inflammatory myopathy.
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Selected References
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- Arahata K., Engel A. G. Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol. 1984 Aug;16(2):193–208. doi: 10.1002/ana.410160206. [DOI] [PubMed] [Google Scholar]
- Behan W. M., Behan P. O. Disturbance of regulatory lymphocyte subsets in polymyositis. Ann Neurol. 1984 Jan;15(1):112–114. doi: 10.1002/ana.410150126. [DOI] [PubMed] [Google Scholar]
- Bohan A., Peter J. B. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975 Feb 13;292(7):344–347. doi: 10.1056/NEJM197502132920706. [DOI] [PubMed] [Google Scholar]
- Haas D. C., Arnason B. G. Cell-mediated immunity in polymyositis. Creatine phosphokinase release from muscle cultures. Arch Neurol. 1974 Sep;31(3):192–196. doi: 10.1001/archneur.1974.00490390074008. [DOI] [PubMed] [Google Scholar]
- Hudgson P., Fulthorpe J. J. The pathology of type II skeletal muscle glycogenosis. A light and electron-microscopic study. J Pathol. 1975 Jul;116(3):139–147. doi: 10.1002/path.1711160303. [DOI] [PubMed] [Google Scholar]
- Iyer V., Lawton A. R., Fenichel G. M. T-cell subsets in polymyositis. Ann Neurol. 1983 Apr;13(4):452–453. doi: 10.1002/ana.410130413. [DOI] [PubMed] [Google Scholar]
- Munsat T. L., Piper D., Cancilla P., Mednick J. Inflammatory myopathy with facioscapulohumeral distribution. Neurology. 1972 Apr;22(4):335–347. doi: 10.1212/wnl.22.4.335. [DOI] [PubMed] [Google Scholar]
- Rowe D. J., Isenberg D. A., McDougall J., Beverley P. C. Characterization of polymyositis infiltrates using monoclonal antibodies to human leucocyte antigens. Clin Exp Immunol. 1981 Aug;45(2):290–298. [PMC free article] [PubMed] [Google Scholar]
- Rowe D., Isenberg D. A., Beverley P. C. Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy. Clin Exp Immunol. 1983 Nov;54(2):327–336. [PMC free article] [PubMed] [Google Scholar]
- Theofilopoulos A. N., Dixon F. J. Autoimmune diseases: immunopathology and etiopathogenesis. Am J Pathol. 1982 Sep;108(3):319–365. [PMC free article] [PubMed] [Google Scholar]
- Wulff J. D., Lin J. T., Kepes J. J. Inflammatory facioscapulohumeral muscular dystrophy and Coats syndrome. Ann Neurol. 1982 Oct;12(4):398–401. doi: 10.1002/ana.410120415. [DOI] [PubMed] [Google Scholar]