Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1997 Mar;50(3):254–256. doi: 10.1136/jcp.50.3.254

Hashimoto's thyroiditis associated with urticaria and angio-oedema: disappearance of cutaneous and mucosal manifestations after thyroidectomy.

A Amoroso 1, P Garzia 1, C Pasquarelli 1, G Sportelli 1, A Afeltra 1
PMCID: PMC499824  PMID: 9155680

Abstract

A 60 year old woman affected by Hashimoto's thyroiditis presented with a history of recurring episodes of urticaria and angio-oedema. Clinical and laboratory evaluation of the patient excluded allergy to external agents, hereditary angio-oedema, and occult infections. A pathogenic relation between Hashimoto's thyroiditis and chronic urticaria/angio-oedema was suspected. However, treatment with L-thyroxine had no influence on the frequency and severity of the cutaneous and mucosal manifestations, which occurred almost daily and required repeated administration of steroids. The patient therefore underwent total thyroidectomy. Cytometric analysis of intrathyroidal lymphocyte subsets showed unusual abnormalities. Urticaria and angio-oedema completely remitted after surgery; 18 months postoperatively the patient was still asymptomatic.

Full text

PDF
254

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altus P., Blandon R., Wallach P. M., Flannery M. T. Case report: the spectrum of autoimmune thyroid disease with urticaria. Am J Med Sci. 1993 Dec;306(6):379–380. doi: 10.1097/00000441-199312000-00005. [DOI] [PubMed] [Google Scholar]
  2. Brenner M. B., Strominger J. L., Krangel M. S. The gamma delta T cell receptor. Adv Immunol. 1988;43:133–192. [PubMed] [Google Scholar]
  3. Espiner E., Donaldson I., Chapman B., Bergeron C. Diencephalic idiopathic gliosis: an unusual hypothalamic syndrome of dermopathy, diarrhea and growth arrest. J Endocrinol Invest. 1992 Sep;15(8):609–616. doi: 10.1007/BF03344934. [DOI] [PubMed] [Google Scholar]
  4. Haas W., Pereira P., Tonegawa S. Gamma/delta cells. Annu Rev Immunol. 1993;11:637–685. doi: 10.1146/annurev.iy.11.040193.003225. [DOI] [PubMed] [Google Scholar]
  5. Iwatani Y., Hidaka Y., Matsuzuka F., Kuma K., Amino N. Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/-CD4-CD8- cells, in autoimmune thyroid disease. Clin Exp Immunol. 1993 Sep;93(3):430–436. doi: 10.1111/j.1365-2249.1993.tb08196.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lanigan S. W., Short P., Moult P. The association of chronic urticaria and thyroid autoimmunity. Clin Exp Dermatol. 1987 Sep;12(5):335–338. doi: 10.1111/j.1365-2230.1987.tb02503.x. [DOI] [PubMed] [Google Scholar]
  7. Leznoff A., Josse R. G., Denburg J., Dolovich J. Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol. 1983 Aug;119(8):636–640. [PubMed] [Google Scholar]
  8. Leznoff A., Sussman G. L. Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients. J Allergy Clin Immunol. 1989 Jul;84(1):66–71. doi: 10.1016/0091-6749(89)90180-2. [DOI] [PubMed] [Google Scholar]
  9. Rumbyrt J. S., Katz J. L., Schocket A. L. Resolution of chronic urticaria in patients with thyroid autoimmunity. J Allergy Clin Immunol. 1995 Dec;96(6 Pt 1):901–905. doi: 10.1016/s0091-6749(95)70226-1. [DOI] [PubMed] [Google Scholar]
  10. Teng W. P., Cohen S. B., Posnett D. N., Weetman A. P. T cell receptor phenotypes in autoimmune thyroid disease. J Endocrinol Invest. 1990 Apr;13(4):339–342. doi: 10.1007/BF03349575. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES