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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1986 Aug;39(8):897–899. doi: 10.1136/jcp.39.8.897

Autoimmunity in chronic liver disease caused by hepatitis delta virus.

D Zauli, C Crespi, F B Bianchi, A Craxi, E Pisi
PMCID: PMC500125  PMID: 3745480

Abstract

Recent evidence shows that chronic liver disease induced by hepatitis delta virus is closely associated with production of autoantibodies. To verify this sera from patients with hepatitis delta virus and from those with hepatitis B virus mediated chronic liver disease were tested for a panel of autoantibodies. Although the traditional non-organ specific autoantibodies were similarly distributed in the two groups, a considerably higher prevalence of IgG basal cell layer antibodies, IgM anti-intermediate filaments, and IgG antimicrotubule antibodies was found. Although these phenomena might be secondary to hepatitis delta virus infection, they might be the serological markers of underlying immune events.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crivelli O., Lavarini C., Chiaberge E., Amoroso A., Farci P., Negro F., Rizzetto M. Microsomal autoantibodies in chronic infection with the HBsAg associated delta (delta) agent. Clin Exp Immunol. 1983 Oct;54(1):232–238. [PMC free article] [PubMed] [Google Scholar]
  2. Cunningham A. L., Mackay I. R., Frazer I. H., Brown C., Pedersen J. S., Toh B. H., Tait B. D., Clarke F. M. Antibody to G-actin in different categories of alcoholic liver disease: quantification by an ELISA and significance for alcoholic cirrhosis. Clin Immunol Immunopathol. 1985 Feb;34(2):158–164. doi: 10.1016/0090-1229(85)90020-0. [DOI] [PubMed] [Google Scholar]
  3. Dales S., Fujinami R. S., Oldstone M. B. Serologic relatedness between Thy-1.2 and actin revealed by monoclonal antibody. J Immunol. 1983 Sep;131(3):1332–1338. [PubMed] [Google Scholar]
  4. Dulbecco R., Unger M., Bologna M., Battifora H., Syka P., Okada S. Cross-reactivity between Thy-1 and a component of intermediate filaments demonstrated using a monoclonal antibody. Nature. 1981 Aug 20;292(5825):772–774. doi: 10.1038/292772a0. [DOI] [PubMed] [Google Scholar]
  5. Heeg U., Haase W., Brauer D., Falke D. Microtubules and microfilaments in HSV-Infected rabbit-kidney cells. Arch Virol. 1981;70(3):233–246. doi: 10.1007/BF01315130. [DOI] [PubMed] [Google Scholar]
  6. Kurki P., Miettinen A., Salaspuro M., Virtanen I., Stenman S. Cytoskeleton antibodies in chronic active hepatitis, primary biliary cirrhosis, and alcoholic liver disease. Hepatology. 1983 May-Jun;3(3):297–302. doi: 10.1002/hep.1840030304. [DOI] [PubMed] [Google Scholar]
  7. Lenkei R., Biberfeld G., Magnius L. O., Fagraeus A., Biberfeld P. Autoantibodies to the basal cells of squamous epithelium react with thymic epithelial cells. Clin Immunol Immunopathol. 1985 Jan;34(1):11–19. doi: 10.1016/0090-1229(85)90002-9. [DOI] [PubMed] [Google Scholar]
  8. Lösse D., Lauer R., Weder D., Radsak K. Actin distribution and synthesis in human fibroblasts infected by cytomegalovirus. Arch Virol. 1982;71(4):353–359. doi: 10.1007/BF01315066. [DOI] [PubMed] [Google Scholar]
  9. Mackay I. R. Immunological aspects of chronic active hepatitis. Hepatology. 1983 Sep-Oct;3(5):724–728. doi: 10.1002/hep.1840030517. [DOI] [PubMed] [Google Scholar]
  10. Mead G. M., Cowin P., Whitehouse J. M. Antitubulin antibody in healthy adults and patients with infectious mononucleosis and its relationship to smooth muscle antibody (SMA). Clin Exp Immunol. 1980 Feb;39(2):328–336. [PMC free article] [PubMed] [Google Scholar]
  11. Pedersen J. S., Toh B. H., Mackay I. R., Tait B. D., Gust I. D., Kastelan A., Hadzic N. Segregation of autoantibody to cytoskeletal filaments, actin and intermediate filaments with two types of chronic active hepatitis. Clin Exp Immunol. 1982 Jun;48(3):527–532. [PMC free article] [PubMed] [Google Scholar]
  12. Rizzetto M., Verme G. Delta hepatitis--present status. J Hepatol. 1985;1(2):187–193. doi: 10.1016/s0168-8278(85)80766-2. [DOI] [PubMed] [Google Scholar]
  13. Thomas H. C., Pignatelli M., Scully L. J. Viruses and immune reactions in the liver. Scand J Gastroenterol Suppl. 1985;114:105–117. doi: 10.3109/00365528509093771. [DOI] [PubMed] [Google Scholar]
  14. Zauli D., Crespi C., Bianchi F. B., Pisi E. Immunofluorescent detection of anti-cytoskeleton antibodies using vinblastine-treated mononuclear cells. J Immunol Methods. 1985 Sep 3;82(1):77–82. doi: 10.1016/0022-1759(85)90226-1. [DOI] [PubMed] [Google Scholar]
  15. Zauli D., Crespi C., Dall'Amore P., Bianchi F. B., Pisi E. Antibodies to the cytoskeleton components and other autoantibodies in inflammatory bowel disease. Digestion. 1985;32(2):140–144. doi: 10.1159/000199232. [DOI] [PubMed] [Google Scholar]
  16. Zauli D., Crespi C., Mancini A. F., Zerbini M., Bianchi F. B., Pisi E. Relationship between smooth muscle and cytoskeleton antibodies in neuroblastoma. Tumori. 1985 Oct 31;71(5):425–430. doi: 10.1177/030089168507100503. [DOI] [PubMed] [Google Scholar]
  17. Zauli D., Crespi C., Zerbini M. L., Bianchi F. B., Pisi E. Relationships between smooth muscle and cytoskeleton antibodies in human serum samples. Ric Clin Lab. 1985 Apr-Jun;15(2):133–138. doi: 10.1007/BF03029830. [DOI] [PubMed] [Google Scholar]
  18. Zauli D., Fusconi M., Crespi C., Bianchi F. B., Craxi A., Pisi E. Close association between basal cell layer antibodies and hepatitis B virus-associated chronic delta infection. Hepatology. 1984 Nov-Dec;4(6):1103–1106. doi: 10.1002/hep.1840040601. [DOI] [PubMed] [Google Scholar]

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