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. 1996 Apr;49(4):284–289. doi: 10.1136/jcp.49.4.284

Seasonal differences in biochemical parameters of bone remodelling.

A S Douglas 1, M H Miller 1, D M Reid 1, J D Hutchison 1, R W Porter 1, S P Robins 1
PMCID: PMC500449  PMID: 8655702

Abstract

AIMS: To compare bone remodelling parameters in late autumn and early spring in 20 post-menopausal women. METHODS: The parameters measured were serum osteocalcin and its apparent degree of carboxylation (measured by hydroxyapatite binding), total and bone specific alkaline phosphatase and urinary bone resorption markers, (pyridinoline and deoxypyridinoline). RESULTS: Serum osteocalcin concentrations were lower in autumn than in spring but the degree of carboxylation was similar. Total and bone specific alkaline phosphatase activities in serum were higher in autumn than in spring. These results support previous observations. However, notable and previously unreported changes in urinary bone resorption markers were observed. Pyridinoline concentrations were lower and deoxypyridinoline higher in autumn compared with spring. The ratio of pyridinoline:deoxypyridinoline was therefore very different between the seasons. CONCLUSIONS: The results clearly demonstrate that seasonal changes in these variables of bone remodelling must be taken into consideration when designing, reporting or analysing studies of bone metabolism in vivo.

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Selected References

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  1. Bergstralh E. J., Sinaki M., Offord K. P., Wahner H. W., Melton L. J., 3rd Effect of season on physical activity score, back extensor muscle strength, and lumbar bone mineral density. J Bone Miner Res. 1990 Apr;5(4):371–377. doi: 10.1002/jbmr.5650050410. [DOI] [PubMed] [Google Scholar]
  2. Bouillon R. A., Auwerx J. H., Lissens W. D., Pelemans W. K. Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr. 1987 Apr;45(4):755–763. doi: 10.1093/ajcn/45.4.755. [DOI] [PubMed] [Google Scholar]
  3. Delmas P. D. Biochemical markers of bone turnover: methodology and clinical use in osteoporosis. Am J Med. 1991 Nov 25;91(5B):59S–63S. doi: 10.1016/0002-9343(91)90250-2. [DOI] [PubMed] [Google Scholar]
  4. Delmas P. D. Clinical use of biochemical markers of bone remodeling in osteoporosis. Bone. 1992;13 (Suppl 1):S17–S21. doi: 10.1016/s8756-3282(09)80005-7. [DOI] [PubMed] [Google Scholar]
  5. Delmas P. D., Schlemmer A., Gineyts E., Riis B., Christiansen C. Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. J Bone Miner Res. 1991 Jun;6(6):639–644. doi: 10.1002/jbmr.5650060615. [DOI] [PubMed] [Google Scholar]
  6. Devgun M. S., Paterson C. R., Martin B. T. Seasonal changes in the activity of serum alkaline phosphatase. Enzyme. 1981;26(6):301–305. doi: 10.1159/000459198. [DOI] [PubMed] [Google Scholar]
  7. Douglas A. S., Robins S. P., Hutchison J. D., Porter R. W., Stewart A., Reid D. M. Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. Bone. 1995 Jul;17(1):15–20. doi: 10.1016/8756-3282(95)00133-x. [DOI] [PubMed] [Google Scholar]
  8. Eastell R., Calvo M. S., Burritt M. F., Offord K. P., Russell R. G., Riggs B. L. Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis. J Clin Endocrinol Metab. 1992 Mar;74(3):487–494. doi: 10.1210/jcem.74.3.1740481. [DOI] [PubMed] [Google Scholar]
  9. Knapen M. H., Hamulyák K., Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Ann Intern Med. 1989 Dec 15;111(12):1001–1005. doi: 10.7326/0003-4819-111-12-1001. [DOI] [PubMed] [Google Scholar]
  10. Knapen M. H., Jie K. S., Hamulyák K., Vermeer C. Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif Tissue Int. 1993 Aug;53(2):81–85. doi: 10.1007/BF01321883. [DOI] [PubMed] [Google Scholar]
  11. Krall E. A., Sahyoun N., Tannenbaum S., Dallal G. E., Dawson-Hughes B. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med. 1989 Dec 28;321(26):1777–1783. doi: 10.1056/NEJM198912283212602. [DOI] [PubMed] [Google Scholar]
  12. Lips P., Hackeng W. H., Jongen M. J., van Ginkel F. C., Netelenbos J. C. Seasonal variation in serum concentrations of parathyroid hormone in elderly people. J Clin Endocrinol Metab. 1983 Jul;57(1):204–206. doi: 10.1210/jcem-57-1-204. [DOI] [PubMed] [Google Scholar]
  13. McLaren A. M., Isdale A. H., Whiting P. H., Bird H. A., Robins S. P. Physiological variations in the urinary excretion of pyridinium crosslinks of collagen. Br J Rheumatol. 1993 Apr;32(4):307–312. doi: 10.1093/rheumatology/32.4.307. [DOI] [PubMed] [Google Scholar]
  14. Meller Y., Kestenbaum R. S., Galinsky D., Shany S. Seasonal variation in serum levels of vitamin D metabolites and parathormone in geriatric patients with fractures in Southern Israel. Isr J Med Sci. 1986 Jan;22(1):8–11. [PubMed] [Google Scholar]
  15. Merle B., Delmas P. D. Normal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of bone. Bone Miner. 1990 Nov;11(2):237–245. doi: 10.1016/0169-6009(90)90062-k. [DOI] [PubMed] [Google Scholar]
  16. Pratt D. A., Daniloff Y., Duncan A., Robins S. P. Automated analysis of the pyridinium crosslinks of collagen in tissue and urine using solid-phase extraction and reversed-phase high-performance liquid chromatography. Anal Biochem. 1992 Nov 15;207(1):168–175. doi: 10.1016/0003-2697(92)90519-d. [DOI] [PubMed] [Google Scholar]
  17. Price C. P. Multiple forms of human serum alkaline phosphatase: detection and quantitation. Ann Clin Biochem. 1993 Jul;30(Pt 4):355–372. doi: 10.1177/000456329303000403. [DOI] [PubMed] [Google Scholar]
  18. Price P. A., Williamson M. K., Lothringer J. W. Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J Biol Chem. 1981 Dec 25;256(24):12760–12766. [PubMed] [Google Scholar]
  19. Riggs B. L., Wahner H. W., Dunn W. L., Mazess R. B., Offord K. P., Melton L. J., 3rd Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest. 1981 Feb;67(2):328–335. doi: 10.1172/JCI110039. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Robins S. P., Black D., Paterson C. R., Reid D. M., Duncan A., Seibel M. J. Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases. Eur J Clin Invest. 1991 Jun;21(3):310–315. doi: 10.1111/j.1365-2362.1991.tb01375.x. [DOI] [PubMed] [Google Scholar]
  21. Ryhänen L. Lysyl hydroxylase. Further purification and characterization of the enzyme from chick embryos and chick embryo cartilage. Biochim Biophys Acta. 1976 Jun 7;438(1):71–89. doi: 10.1016/0005-2744(76)90224-2. [DOI] [PubMed] [Google Scholar]
  22. Schlemmer A., Hassager C., Jensen S. B., Christiansen C. Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women. J Clin Endocrinol Metab. 1992 Mar;74(3):476–480. doi: 10.1210/jcem.74.3.1740479. [DOI] [PubMed] [Google Scholar]
  23. Stamp T. C., Round J. M. Seasonal changes in human plasma levels of 25-hydroxyvitamin D. Nature. 1974 Feb 22;247(5442):563–565. doi: 10.1038/247563a0. [DOI] [PubMed] [Google Scholar]
  24. Statland B. E., Nishi H. H., Young D. S. Serum alkaline phosphatase: total activity and isoenzyme determinations made by use of the centrifugal fast analyzer. Clin Chem. 1972 Dec;18(12):1468–1474. [PubMed] [Google Scholar]
  25. Szulc P., Chapuy M. C., Meunier P. J., Delmas P. D. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest. 1993 Apr;91(4):1769–1774. doi: 10.1172/JCI116387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Thomsen K., Eriksen E. F., Jørgensen J. C., Charles P., Mosekilde L. Seasonal variation of serum bone GLA protein. Scand J Clin Lab Invest. 1989 Nov;49(7):605–611. doi: 10.1080/00365518909091535. [DOI] [PubMed] [Google Scholar]
  27. von Knorring J., Slätis P., Weber T. H., Helenius T. Serum levels of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and parathyroid hormone in patients with femoral neck fracture in southern Finland. Clin Endocrinol (Oxf) 1982 Aug;17(2):189–194. doi: 10.1111/j.1365-2265.1982.tb01578.x. [DOI] [PubMed] [Google Scholar]

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