Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1996 Jul;49(7):611–613. doi: 10.1136/jcp.49.7.611

Association between thyroid cancer of cribriform variant and familial adenomatous polyposis.

K Hizawa 1, M Iida 1, T Yao 1, K Aoyagi 1, Y Oohata 1, R Mibu 1, K Yamasaki 1, T Hirata 1, M Fujishima 1
PMCID: PMC500586  PMID: 8813970

Abstract

A case of a 20 year old Japanese woman who developed thyroid cancer exhibiting unusual cribriform structures while being followed up for familial adenomatous polyposis/Gardner's syndrome is reported. The patient presented with osteomas, pigmented retinal lesions, and adenomas of the duodenum and the papilla of Vater, in addition to numerous adenomatous polyps in the colorectum. On ultrasonography, the thyroid cancer was localised to the right lobe and was identified as an irregular, internal echo tumour with a peripheral hypoechoic zone, measuring 1.8 cm in diameter. Histological examination of the resected tumour showed a concomitance of papillary proliferation and cribriform structures with follicles of varying sizes. These features can be distinguished from sporadic thyroid cancer.

Full text

PDF
612

Images in this article

612Image
on p.612
612Image
on p.612

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell B., Mazzaferri E. L. Familial adenomatous polyposis (Gardner's syndrome) and thyroid carcinoma. A case report and review of the literature. Dig Dis Sci. 1993 Jan;38(1):185–190. doi: 10.1007/BF01296795. [DOI] [PubMed] [Google Scholar]
  2. Curtis L., Wyllie A. H., Shaw J. J., Williams G. T., Radulescu A., DeMicco C., Haugen D. R., Varhaug J. E., Lillehaug J. R., Wynford-Thomas D. Evidence against involvement of APC mutation in papillary thyroid carcinoma. Eur J Cancer. 1994;30A(7):984–987. doi: 10.1016/0959-8049(94)90129-5. [DOI] [PubMed] [Google Scholar]
  3. Giardiello F. M., Offerhaus G. J., Lee D. H., Krush A. J., Tersmette A. C., Booker S. V., Kelley N. C., Hamilton S. R. Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut. 1993 Oct;34(10):1394–1396. doi: 10.1136/gut.34.10.1394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Harach H. R., Williams G. T., Williams E. D. Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathology. 1994 Dec;25(6):549–561. doi: 10.1111/j.1365-2559.1994.tb01374.x. [DOI] [PubMed] [Google Scholar]
  5. Iwama T., Mishima Y., Utsunomiya J. The impact of familial adenomatous polyposis on the tumorigenesis and mortality at the several organs. Its rational treatment. Ann Surg. 1993 Feb;217(2):101–108. doi: 10.1097/00000658-199302000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kelly M. D., Hugh T. B., Field A. S., Fitzsimons R. Carcinoma of the thyroid gland and Gardner's syndrome. Aust N Z J Surg. 1993 Jun;63(6):505–509. doi: 10.1111/j.1445-2197.1993.tb00439.x. [DOI] [PubMed] [Google Scholar]
  7. Lee F. I., MacKinnon M. D. Papillary thyroid carcinoma associated with polyposis coli. A case of Gardner's syndrome. Am J Gastroenterol. 1981 Aug;76(2):138–140. [PubMed] [Google Scholar]
  8. Piffer S. Gardner's syndrome and thyroid cancer--a case report and review of the literature. Acta Oncol. 1988;27(4):413–415. doi: 10.3109/02841868809093564. [DOI] [PubMed] [Google Scholar]
  9. Plail R. O., Bussey H. J., Glazer G., Thomson J. P. Adenomatous polyposis: an association with carcinoma of the thyroid. Br J Surg. 1987 May;74(5):377–380. doi: 10.1002/bjs.1800740517. [DOI] [PubMed] [Google Scholar]
  10. Smith W. G. Familial multiple polyposis: research tool for investigating the etiology of carcinoma of the colon? Dis Colon Rectum. 1968 Jan-Feb;11(1):17–31. doi: 10.1007/BF02616741. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES