Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1993 Feb;46(2):183–185. doi: 10.1136/jcp.46.2.183

Mixed adenocarcinoma/carcinoid tumour of large bowel in a patient with Crohn's disease.

Y L Hock 1, K W Scott 1, R H Grace 1
PMCID: PMC501156  PMID: 8459042

Abstract

A 50 year old woman with a 20 year history of Crohn's disease underwent laparotomy which revealed extensive disease in the small and large bowel, and this was resected. Gross examination of the resected bowel showed features of Crohn's disease as well as a polypoid tumour in the caecum. Histopathological examination of the tumour showed it to be an infiltrating mixed adenocarcinoma/carcinoid tumour arising in a tubulovillous adenoma. Random sampling of the rest of the bowel affected by Crohn's disease also showed a focus of dysplasia and adenomatous change. It is suggested that Crohn's disease may have played a part in the pathogenesis of the tumour.

Full text

PDF
184

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Craft C. F., Mendelsohn G., Cooper H. S., Yardley J. H. Colonic "precancer" in Crohn's disease. Gastroenterology. 1981 Mar;80(3):578–584. [PubMed] [Google Scholar]
  2. Gledhill A., Hall P. A., Cruse J. P., Pollock D. J. Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long-standing ulcerative colitis. Histopathology. 1986 May;10(5):501–508. doi: 10.1111/j.1365-2559.1986.tb02501.x. [DOI] [PubMed] [Google Scholar]
  3. Hamilton S. R. Colorectal carcinoma in patients with Crohn's disease. Gastroenterology. 1985 Aug;89(2):398–407. doi: 10.1016/0016-5085(85)90343-9. [DOI] [PubMed] [Google Scholar]
  4. Klappenbach R. S., Kurman R. J., Sinclair C. F., James L. P. Composite carcinoma-carcinoid tumors of the gastrointestinal tract. A morphologic, histochemical, and immunocytochemical study. Am J Clin Pathol. 1985 Aug;84(2):137–143. doi: 10.1093/ajcp/84.2.137. [DOI] [PubMed] [Google Scholar]
  5. Lyss A. P., Thompson J. J., Glick J. H. Adenocarcinoid tumor of the colon arising in preexisting ulcerative colitis. Cancer. 1981 Aug 1;48(3):833–839. doi: 10.1002/1097-0142(19810801)48:3<833::aid-cncr2820480328>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  6. Savoca P. E., Ballantyne G. H., Cahow C. E. Gastrointestinal malignancies in Crohn's disease. A 20-year experience. Dis Colon Rectum. 1990 Jan;33(1):7–11. doi: 10.1007/BF02053192. [DOI] [PubMed] [Google Scholar]
  7. Thompson E. M., Clayden G., Price A. B. Cancer in Crohn's disease--an 'occult' malignancy. Histopathology. 1983 May;7(3):365–376. doi: 10.1111/j.1365-2559.1983.tb02250.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES