Abstract
The proliferation indices (PIs) were determined in 33 meningiomas using two monoclonal antibodies to the Ki-67 antigen (Ki-67 and MIB1). PIs obtained using Ki-67 on frozen material were intermediate between the lowest and highest MIB1 PIs determined in paraffin wax sections. Preoperative embolisation did not influence Ki67 PI, but four of the 15 embolised tumours showed substantially increased MIB1 PIs around embolisation necroses. Proliferation can be reliably assessed in routinely processed meningioma tissues using MIB1; and increased perinecrotic PIs may occur in embolised meningiomas without being an indication of malignancy.
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- Allegranza A., Girlando S., Arrigoni G. L., Veronese S., Mauri F. A., Gambacorta M., Pollo B., Dalla Palma P., Barbareschi M. Proliferating cell nuclear antigen expression in central nervous system neoplasms. Virchows Arch A Pathol Anat Histopathol. 1991;419(5):417–423. doi: 10.1007/BF01605076. [DOI] [PubMed] [Google Scholar]
- Cattoretti G., Becker M. H., Key G., Duchrow M., Schlüter C., Galle J., Gerdes J. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol. 1992 Dec;168(4):357–363. doi: 10.1002/path.1711680404. [DOI] [PubMed] [Google Scholar]
- Gerdes J., Becker M. H., Key G., Cattoretti G. Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J Pathol. 1992 Sep;168(1):85–86. doi: 10.1002/path.1711680114. [DOI] [PubMed] [Google Scholar]
- Gottschalk J., Goebel S., Jautzke G., Martin H., Zimmer C., Märzheuser-Brands S., Cervós-Navarro J. Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas. Histol Histopathol. 1992 Oct;7(4):653–661. [PubMed] [Google Scholar]
- Kleihues P., Kiessling M., Janzer R. C. Morphological markers in neuro-oncology. Curr Top Pathol. 1987;77:307–338. doi: 10.1007/978-3-642-71356-9_13. [DOI] [PubMed] [Google Scholar]
- Paulus W., Grothe C., Sensenbrenner M., Janet T., Baur I., Graf M., Roggendorf W. Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors. Acta Neuropathol. 1990;79(4):418–423. doi: 10.1007/BF00308718. [DOI] [PubMed] [Google Scholar]
- Richter H. P., Schachenmayr W. Preoperative embolization of intracranial meningiomas. Neurosurgery. 1983 Sep;13(3):261–268. doi: 10.1227/00006123-198309000-00008. [DOI] [PubMed] [Google Scholar]
- Roggendorf W., Schuster T., Peiffer J. Proliferative potential of meningiomas determined with the monoclonal antibody Ki-67. Acta Neuropathol. 1987;73(4):361–364. doi: 10.1007/BF00688260. [DOI] [PubMed] [Google Scholar]