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. 1994 Jan;47(1):33–37. doi: 10.1136/jcp.47.1.33

Relation of CD30 expression to survival and morphology in large cell B cell lymphomas.

L A Noorduyn 1, P C de Bruin 1, P van Heerde 1, M M van de Sandt 1, G J Ossenkoppele 1, C J Meijer 1
PMCID: PMC501753  PMID: 8132806

Abstract

AIMS--To investigate whether CD30 expression is correlated with anaplastic morphology, and whether this correlated with a better survival in large cell B cell lymphomas, as has been described for T cell lymphomas. METHODS--CD30 expression was investigated using frozen sections in a series of 146 large cell B cell lymphomas. Clinical data and follow up information were collected from 25 lymphomas with strong CD30 expression, 30 lymphomas with partial CD30 expression, and a control group of 25 lymphomas which did not express CD30. RESULTS--Morphological distinction between anaplastic and non-anaplastic tumours was difficult. Of the cases with an anaplastic morphology, 50% were CD30 positive, as were 24% of the polymorphic centroblastic B cell lymphomas. Only 65% of the morphologically non-anaplastic tumours were completely CD30 negative. There was no difference in survival among patients with lymphomas expressing CD30 and those that did not. Patients with morphologically anaplastic B cell lymphomas did not differ in their survivals from those with other high grade B cell lymphomas. Clinical stage at presentation was the only variable that was significantly associated with survival. CONCLUSIONS--CD30 expression occurs frequently in large cell B cell lymphomas and is poorly related to anaplastic morphology. Morphological distinction between anaplastic and non-anaplastic tumours is difficult. In contrast to T cell lymphomas, CD30 positive B cell lymphomas do not show a relatively favourable clinical course. The results presented here raise serious doubts as to whether large cell B cell lymphoma, based on the expression of CD30 or anaplastic morphology, can really be termed a separate entity.

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Selected References

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  1. Agnarsson B. A., Kadin M. E. Ki-1 positive large cell lymphoma. A morphologic and immunologic study of 19 cases. Am J Surg Pathol. 1988 Apr;12(4):264–274. doi: 10.1097/00000478-198804000-00002. [DOI] [PubMed] [Google Scholar]
  2. Beljaards R. C., Meijer C. J., Scheffer E., Toonstra J., van Vloten W. A., van der Putte S. C., Geerts M. L., Willemze R. Prognostic significance of CD30 (Ki-1/Ber-H2) expression in primary cutaneous large-cell lymphomas of T-cell origin. A clinicopathologic and immunohistochemical study in 20 patients. Am J Pathol. 1989 Dec;135(6):1169–1178. [PMC free article] [PubMed] [Google Scholar]
  3. Bitter M. A., Franklin W. A., Larson R. A., McKeithan T. W., Rubin C. M., Le Beau M. M., Stephens J. K., Vardiman J. W. Morphology in Ki-1(CD30)-positive non-Hodgkin's lymphoma is correlated with clinical features and the presence of a unique chromosomal abnormality, t(2;5)(p23;q35). Am J Surg Pathol. 1990 Apr;14(4):305–316. doi: 10.1097/00000478-199004000-00001. [DOI] [PubMed] [Google Scholar]
  4. Chan J. K., Buchanan R., Fletcher C. D. Sarcomatoid variant of anaplastic large-cell Ki-1 lymphoma. Am J Surg Pathol. 1990 Oct;14(10):983–988. doi: 10.1097/00000478-199010000-00013. [DOI] [PubMed] [Google Scholar]
  5. Chan J. K., Ng C. S., Hui P. K., Leung T. W., Lo E. S., Lau W. H., McGuire L. J. Anaplastic large cell Ki-1 lymphoma. Delineation of two morphological types. Histopathology. 1989 Jul;15(1):11–34. doi: 10.1111/j.1365-2559.1989.tb03038.x. [DOI] [PubMed] [Google Scholar]
  6. Chott A., Kaserer K., Augustin I., Vesely M., Heinz R., Oehlinger W., Hanak H., Radaszkiewicz T. Ki-1-positive large cell lymphoma. A clinicopathologic study of 41 cases. Am J Surg Pathol. 1990 May;14(5):439–448. doi: 10.1097/00000478-199005000-00003. [DOI] [PubMed] [Google Scholar]
  7. Dürkop H., Latza U., Hummel M., Eitelbach F., Seed B., Stein H. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell. 1992 Feb 7;68(3):421–427. doi: 10.1016/0092-8674(92)90180-k. [DOI] [PubMed] [Google Scholar]
  8. Falini B., Pileri S., Stein H., Dieneman D., Dallenbach F., Delsol G., Minelli O., Poggi S., Martelli M. F., Pallesen G. Variable expression of leucocyte-common (CD45) antigen in CD30 (Ki1)-positive anaplastic large-cell lymphoma: implications for the differential diagnosis between lymphoid and nonlymphoid malignancies. Hum Pathol. 1990 Jun;21(6):624–629. doi: 10.1016/s0046-8177(96)90009-x. [DOI] [PubMed] [Google Scholar]
  9. Hastrup N., Hamilton-Dutoit S., Ralfkiaer E., Pallesen G. Peripheral T-cell lymphomas: an evaluation of reproducibility of the updated Kiel classification. Histopathology. 1991 Feb;18(2):99–105. doi: 10.1111/j.1365-2559.1991.tb01451.x. [DOI] [PubMed] [Google Scholar]
  10. Hutchison R. E., Fairclough D. L., Holt H., Pui C. H., Sandlund J. T., Berard C. W. Clinical significance of histology and immunophenotype in childhood diffuse large cell lymphoma. Am J Clin Pathol. 1991 Jun;95(6):787–793. doi: 10.1093/ajcp/95.6.787. [DOI] [PubMed] [Google Scholar]
  11. Le Tourneau A., Audouin J., Diebold J., Pujade-Lauraine E., Bernadou A. Large anaplastic cell Ki-1 positive malignant lymphoma with peculiar endocytotic vacuoles. Pathol Res Pract. 1990 Dec;186(6):784–794. doi: 10.1016/S0344-0338(11)80270-0. [DOI] [PubMed] [Google Scholar]
  12. Nakamura S., Takagi N., Kojima M., Motoori T., Kitoh K., Osada H., Suzuki H., Ogura M., Kurita S., Oyama A. Clinicopathologic study of large cell anaplastic lymphoma (Ki-1-positive large cell lymphoma) among the Japanese. Cancer. 1991 Jul 1;68(1):118–129. doi: 10.1002/1097-0142(19910701)68:1<118::aid-cncr2820680123>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  13. Noorduyn L. A., van Heerde P., Meyer C. J. Cytology of Ki-1 (CD-30) positive large cell lymphoma. Cytopathology. 1990;1(5):297–304. doi: 10.1111/j.1365-2303.1990.tb00363.x. [DOI] [PubMed] [Google Scholar]
  14. O'Connor N. T., Stein H., Gatter K. C., Wainscoat J. S., Crick J., Al Saati T., Falini B., Delsol G., Mason D. Y. Genotypic analysis of large cell lymphomas which express the Ki-1 antigen. Histopathology. 1987 Jul;11(7):733–740. doi: 10.1111/j.1365-2559.1987.tb02687.x. [DOI] [PubMed] [Google Scholar]
  15. Ohshima K., Kikuchi M., Masuda Y., Yoshida T., Mohtai H., Eguchi F., Kimura N., Takihara Y. Genotypic and immunophenotypic analysis of anaplastic large cell lymphoma (Ki-1 lymphoma). Pathol Res Pract. 1990 Oct;186(5):582–588. doi: 10.1016/S0344-0338(11)80221-9. [DOI] [PubMed] [Google Scholar]
  16. Oka K., Mori N., Kojima M., Iijima T., Hanada T., Tsuchida M. Childhood Ki-1 lymphoma. A report of two cases. Arch Pathol Lab Med. 1989 Sep;113(9):998–1002. [PubMed] [Google Scholar]
  17. Pallesen G. The diagnostic significance of the CD30 (Ki-1) antigen. Histopathology. 1990 Apr;16(4):409–413. doi: 10.1111/j.1365-2559.1990.tb01151.x. [DOI] [PubMed] [Google Scholar]
  18. Penny R. J., Blaustein J. C., Longtine J. A., Pinkus G. S. Ki-1-positive large cell lymphomas, a heterogenous group of neoplasms. Morphologic, immunophenotypic, genotypic, and clinical features of 24 cases. Cancer. 1991 Jul 15;68(2):362–373. doi: 10.1002/1097-0142(19910715)68:2<362::aid-cncr2820680226>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  19. Pileri S., Falini B., Delsol G., Stein H., Baglioni P., Poggi S., Martelli M. F., Rivano M. T., Mason D. Y., Stansfeld A. G. Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1 + with a high content of reactive histiocytes). Histopathology. 1990 Apr;16(4):383–391. doi: 10.1111/j.1365-2559.1990.tb01143.x. [DOI] [PubMed] [Google Scholar]
  20. Piris M., Brown D. C., Gatter K. C., Mason D. Y. CD30 expression in non-Hodgkin's lymphoma. Histopathology. 1990 Sep;17(3):211–218. doi: 10.1111/j.1365-2559.1990.tb00709.x. [DOI] [PubMed] [Google Scholar]
  21. Rohde D., Hansen H., Hafner M., Lange H., Mielke V., Hansmann M. L., Lemke H. Cellular localizations and processing of the two molecular forms of the Hodgkin-associated Ki-1 (CD30) antigen. The protein kinase Ki-1/57 occurs in the nucleus. Am J Pathol. 1992 Feb;140(2):473–482. [PMC free article] [PubMed] [Google Scholar]
  22. Schnitzer B., Roth M. S., Hyder D. M., Ginsburg D. Ki-1 lymphomas in children. Cancer. 1988 Mar 15;61(6):1213–1221. doi: 10.1002/1097-0142(19880315)61:6<1213::aid-cncr2820610626>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  23. Schwab U., Stein H., Gerdes J., Lemke H., Kirchner H., Schaadt M., Diehl V. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature. 1982 Sep 2;299(5878):65–67. doi: 10.1038/299065a0. [DOI] [PubMed] [Google Scholar]
  24. Schwarting R., Gerdes J., Dürkop H., Falini B., Pileri S., Stein H. BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood. 1989 Oct;74(5):1678–1689. [PubMed] [Google Scholar]
  25. Stansfeld A. G., Diebold J., Noel H., Kapanci Y., Rilke F., Kelényi G., Sundstrom C., Lennert K., van Unnik J. A., Mioduszewska O. Updated Kiel classification for lymphomas. Lancet. 1988 Feb 6;1(8580):292–293. doi: 10.1016/s0140-6736(88)90367-4. [DOI] [PubMed] [Google Scholar]
  26. Stein H., Mason D. Y., Gerdes J., O'Connor N., Wainscoat J., Pallesen G., Gatter K., Falini B., Delsol G., Lemke H. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985 Oct;66(4):848–858. [PubMed] [Google Scholar]
  27. Suchi T., Lennert K., Tu L. Y., Kikuchi M., Sato E., Stansfeld A. G., Feller A. C. Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification. J Clin Pathol. 1987 Sep;40(9):995–1015. doi: 10.1136/jcp.40.9.995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Tashiro K., Kikuchi M., Takeshita M., Yoshida T., Ohshima K. Clinicopathological study of Ki-1-positive lymphomas. Pathol Res Pract. 1989 Oct;185(4):461–467. doi: 10.1016/S0344-0338(89)80063-9. [DOI] [PubMed] [Google Scholar]
  29. de Bruin P. C., Noorduyn A. L., van der Valk P., van Heerde P., van Diest P. J., van de Sandt M. M., Ossenkoppele G. J., Meijer C. J. Noncutaneous T-cell lymphomas. Recognition of a lymphoma type (large cell anaplastic) with a relatively favorable prognosis. Cancer. 1993 Apr 15;71(8):2604–2612. doi: 10.1002/1097-0142(19930415)71:8<2604::aid-cncr2820710827>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]

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