Abstract
AIMS--To investigate a female patient with a tumour mass of the terminal ileum, to define the nature of the tumour, and to correlate its morphology and behaviour with similar types of tumours of the large intestine and stomach. METHODS--Tissues obtained at colonoscopy, from hemicolectomy specimens, and from liver and peritoneal biopsy specimens were studied macroscopically, microscopically, histochemically, and immunohistochemically for epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and S100 protein. RESULTS--Macroscopic examination showed a tumour of the terminal ileum protruding into the caecum. Microscopically the tumour showed two components, one adenoma with moderate dysplasia and the other carcinoid tumour. The adenomatous component stained positively for EMA and CEA and negatively for NSE. The carcinoid component stained positively for NSE and negatively for EMA and CEA. Histochemically the carcinoid area was argyrophil positive and argentaffin negative. Only the carcinoid had metastasised, to the liver, peritoneum, and the lymph nodes, at the time of diagnosis. CONCLUSION--The morphological, histochemical, and immunohistochemical findings confirm the diagnosis of a composite adenoma-carcinoid tumour of the terminal ileum.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bates H. R., Jr, Belter L. F. Composite carcinoid tumor (argentaffinoma-adenocarcinoma) of the colon: report of 2 cases. Dis Colon Rectum. 1967 Nov-Dec;10(6):467–470. doi: 10.1007/BF02616821. [DOI] [PubMed] [Google Scholar]
- Caruso M. L., Pilato F. P., D'Adda T., Baggi M. T., Fucci L., Valentini A. M., Lacatena M., Bordi C. Composite carcinoid-adenocarcinoma of the stomach associated with multiple gastric carcinoids and nonantral gastric atrophy. Cancer. 1989 Oct 1;64(7):1534–1539. doi: 10.1002/1097-0142(19891001)64:7<1534::aid-cncr2820640730>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Damjanov I., Amenta P. S., Bosman F. T. Undifferentiated carcinoma of the colon containing exocrine, neuroendocrine and squamous cells. Virchows Arch A Pathol Anat Histopathol. 1983;401(1):57–66. doi: 10.1007/BF00644789. [DOI] [PubMed] [Google Scholar]
- Hock Y. L., Scott K. W., Grace R. H. Mixed adenocarcinoma/carcinoid tumour of large bowel in a patient with Crohn's disease. J Clin Pathol. 1993 Feb;46(2):183–185. doi: 10.1136/jcp.46.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lyss A. P., Thompson J. J., Glick J. H. Adenocarcinoid tumor of the colon arising in preexisting ulcerative colitis. Cancer. 1981 Aug 1;48(3):833–839. doi: 10.1002/1097-0142(19810801)48:3<833::aid-cncr2820480328>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Mills S. E., Allen M. S., Jr, Cohen A. R. Small-cell undifferentiated carcinoma of the colon. A clinicopathological study of five cases and their association with colonic adenomas. Am J Surg Pathol. 1983 Oct;7(7):643–651. doi: 10.1097/00000478-198310000-00005. [DOI] [PubMed] [Google Scholar]
- Mori K., Shinya H., Kalisman M. A composite tumor in tubulovillous adenoma of the rectum. Dis Colon Rectum. 1978 Oct;21(7):506–509. doi: 10.1007/BF02586737. [DOI] [PubMed] [Google Scholar]
- Moyana T. N., Qizilbash A. H., Murphy F. Composite glandular-carcinoid tumors of the colon and rectum. Report of two cases. Am J Surg Pathol. 1988 Aug;12(8):607–611. doi: 10.1097/00000478-198808000-00001. [DOI] [PubMed] [Google Scholar]
- Palvio D. H., Sørensen F. B., Kløve-Mogensen M. Stem cell carcinoma of the colon and rectum. Report of two cases and review of the literature. Dis Colon Rectum. 1985 Jun;28(6):440–445. doi: 10.1007/BF02560233. [DOI] [PubMed] [Google Scholar]
- Perzin K. H., Bridge M. F. Adenomas of the small intestine: a clinicopathologic review of 51 cases and a study of their relationship to carcinoma. Cancer. 1981 Aug 1;48(3):799–819. doi: 10.1002/1097-0142(19810801)48:3<799::aid-cncr2820480324>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
- Petrelli M., Tetangco E., Reid J. D. Carcinoma of the colon with undifferentiated, carcinoid, and squamous cell features. Am J Clin Pathol. 1981 Apr;75(4):581–584. doi: 10.1093/ajcp/75.4.581. [DOI] [PubMed] [Google Scholar]