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. 1994 May;47(5):436–439. doi: 10.1136/jcp.47.5.436

Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas.

S Eidt 1, M Stolte 1, R Fischer 1
PMCID: PMC502021  PMID: 8027397

Abstract

AIMS--To evaluate further the relation between gastric malignant lymphoma of the mucosa associated lymphoid tissue (MALT) and Helicobacter pylori. METHODS--One hundred and sixty two surgical specimens of MALT lymphoma were retrospectively investigated to determine tumour type and inflammatory patterns. In 121 cases biopsy specimens obtained before surgery were available and stained with haematoxylin and eosin, periodic acid Schiff, Giemsa and Warthin-Starry stains. RESULTS--Residual lymphoid follicles were found less often in high grade malignant than in low grade malignant MALT lymphomas. Chronic active gastritis was shown within the mucosa at some distance from the tumours in 143 of 146 specimens. In all the cases for which biopsy specimens could be evaluated, colonisation of the mucosa by H pylori had occurred. Lymphoid follicles and lymphoid aggregates were detected in 82.7% of the antral, and in 85% of the body mucosa specimens. CONCLUSIONS--These data support the hypothesis that H pylori has an important role in the development of MALT lymphomas. Furthermore, the chronic inflammation preceding malignant transformation might enhance the probability of malignant transformation via chronic stimulation of the lymphoid tissue. This might in part indicate why MALT lymphomas occur most often in the stomach.

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Selected References

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  1. Crabtree J. E., Mahony M. J., Taylor J. D., Heatley R. V., Littlewood J. M., Tompkins D. S. Immune responses to Helicobacter pylori in children with recurrent abdominal pain. J Clin Pathol. 1991 Sep;44(9):768–771. doi: 10.1136/jcp.44.9.768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dixon M. F., O'Connor H. J., Axon A. T., King R. F., Johnston D. Reflux gastritis: distinct histopathological entity? J Clin Pathol. 1986 May;39(5):524–530. doi: 10.1136/jcp.39.5.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Doglioni C., Wotherspoon A. C., Moschini A., de Boni M., Isaacson P. G. High incidence of primary gastric lymphoma in northeastern Italy. Lancet. 1992 Apr 4;339(8797):834–835. doi: 10.1016/0140-6736(92)90280-g. [DOI] [PubMed] [Google Scholar]
  4. Eidt S., Stolte M. Antral intestinal metaplasia in Helicobacter pylori gastritis. Digestion. 1994;55(1):13–18. doi: 10.1159/000201116. [DOI] [PubMed] [Google Scholar]
  5. Fiocca R., Solcia E., Santoro B. Duodenal ulcer relapse after eradication of Helicobacter pylori. Lancet. 1991 Jun 29;337(8757):1614–1614. doi: 10.1016/0140-6736(91)93316-2. [DOI] [PubMed] [Google Scholar]
  6. Forman D., Newell D. G., Fullerton F., Yarnell J. W., Stacey A. R., Wald N., Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991 Jun 1;302(6788):1302–1305. doi: 10.1136/bmj.302.6788.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Freeman C., Berg J. W., Cutler S. J. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972 Jan;29(1):252–260. doi: 10.1002/1097-0142(197201)29:1<252::aid-cncr2820290138>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  8. Haot J., Hamichi L., Wallez L., Mainguet P. Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study. Gut. 1988 Sep;29(9):1258–1264. doi: 10.1136/gut.29.9.1258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Herrmann R., Panahon A. M., Barcos M. P., Walsh D., Stutzman L. Gastrointestinal involvement in non-Hodgkin's lymphoma. Cancer. 1980 Jul 1;46(1):215–222. doi: 10.1002/1097-0142(19800701)46:1<215::aid-cncr2820460136>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  10. Isaacson P. G., Spencer J., Wright D. H. Classifying primary gut lymphomas. Lancet. 1988 Nov 12;2(8620):1148–1149. doi: 10.1016/s0140-6736(88)90574-0. [DOI] [PubMed] [Google Scholar]
  11. Krueger G. R., Papadakis T., Schaefer H. J. Persistent active Epstein-Barr virus infection and atypical lymphoproliferation. Report of two cases. Am J Surg Pathol. 1987 Dec;11(12):972–981. doi: 10.1097/00000478-198712000-00008. [DOI] [PubMed] [Google Scholar]
  12. Marshall B. J., Goodwin C. S., Warren J. R., Murray R., Blincow E. D., Blackbourn S. J., Phillips M., Waters T. E., Sanderson C. R. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988 Dec 24;2(8626-8627):1437–1442. doi: 10.1016/s0140-6736(88)90929-4. [DOI] [PubMed] [Google Scholar]
  13. Musshoff K., Schmidt-Vollmer H. Proceedings: Prognosis of non-Hodgkin's lymphomas with special emphasis on the staging classification. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Aug 8;83(4):323–341. doi: 10.1007/BF00573019. [DOI] [PubMed] [Google Scholar]
  14. Nomura A., Stemmermann G. N., Chyou P. H., Kato I., Perez-Perez G. I., Blaser M. J. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991 Oct 17;325(16):1132–1136. doi: 10.1056/NEJM199110173251604. [DOI] [PubMed] [Google Scholar]
  15. Otter R., Bieger R., Kluin P. M., Hermans J., Willemze R. Primary gastrointestinal non-Hodgkin's lymphoma in a population-based registry. Br J Cancer. 1989 Nov;60(5):745–750. doi: 10.1038/bjc.1989.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Parsonnet J., Vandersteen D., Goates J., Sibley R. K., Pritikin J., Chang Y. Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst. 1991 May 1;83(9):640–643. doi: 10.1093/jnci/83.9.640. [DOI] [PubMed] [Google Scholar]
  17. Radaszkiewicz T., Dragosics B., Bauer P. Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis. Gastroenterology. 1992 May;102(5):1628–1638. doi: 10.1016/0016-5085(92)91723-h. [DOI] [PubMed] [Google Scholar]
  18. Stolte M., Eidt S. Lymphoid follicles in antral mucosa: immune response to Campylobacter pylori? J Clin Pathol. 1989 Dec;42(12):1269–1271. doi: 10.1136/jcp.42.12.1269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stolte M., Eidt S., Ohnsmann A. Differences in Helicobacter pylori associated gastritis in the antrum and body of the stomach. Z Gastroenterol. 1990 May;28(5):229–233. [PubMed] [Google Scholar]
  20. Stolte M. Helicobacter pylori gastritis and gastric MALT-lymphoma. Lancet. 1992 Mar 21;339(8795):745–746. doi: 10.1016/0140-6736(92)90645-j. [DOI] [PubMed] [Google Scholar]
  21. Wotherspoon A. C., Ortiz-Hidalgo C., Falzon M. R., Isaacson P. G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991 Nov 9;338(8776):1175–1176. doi: 10.1016/0140-6736(91)92035-z. [DOI] [PubMed] [Google Scholar]
  22. Wyatt J. I., Rathbone B. J. Immune response of the gastric mucosa to Campylobacter pylori. Scand J Gastroenterol Suppl. 1988;142:44–49. [PubMed] [Google Scholar]

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