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. 1990 Jun;43(6):457–460. doi: 10.1136/jcp.43.6.457

Incidence of thin membrane nephropathy: morphometric investigation of a population sample.

F E Dische 1, V E Anderson 1, S J Keane 1, D Taube 1, M Bewick 1, V Parsons 1
PMCID: PMC502496  PMID: 2380394

Abstract

To explore the incidence of thin membrane nephropathy (thin basement membrane syndrome, benign familial haematuria), glomerular basement membrane thickness was assessed by light and electron microscopy and by morphometry in a series of newly transplanted allograft kidneys, in lieu of normal kidney specimens. Five of the 76 donors possessed an abnormally thin basement membrane, similar to that observed in thin membrane nephropathy, while in two others the measurements fell in the overlap range between thin and normal. Seven donors therefore had a definite or possible basement membrane lesion. After taking account of an additional series of controls, unrelated to transplantation, it is suggested that the incidence of this abnormality in the general population lies between 5.2% and 9.2%. Circumstances did not allow any association between a thin basement membrane and haematuria or other clinical manifestations to be detected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe S., Amagasaki Y., Iyori S., Konishi K., Kato E., Sakaguchi H., Shimoyama K. Thin basement membrane syndrome in adults. J Clin Pathol. 1987 Mar;40(3):318–322. doi: 10.1136/jcp.40.3.318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Busch G. J., Reynolds E. S., Galvanek E. G., Braun W. E., Dammin G. J. Human renal allografts. The role of vascular injury in early graft failure. Medicine (Baltimore) 1971 Jan;50(1):29–83. [PubMed] [Google Scholar]
  3. Coleman M., Haynes W. D., Dimopoulos P., Barratt L. J., Jarvis L. R. Glomerular basement membrane abnormalities associated with apparently idiopathic hematuria: ultrastructural morphometric analysis. Hum Pathol. 1986 Oct;17(10):1022–1030. doi: 10.1016/s0046-8177(86)80086-7. [DOI] [PubMed] [Google Scholar]
  4. Dische F. E., Weston M. J., Parsons V. Abnormally thin glomerular basement membranes associated with hematuria, proteinuria or renal failure in adults. Am J Nephrol. 1985;5(2):103–109. doi: 10.1159/000166914. [DOI] [PubMed] [Google Scholar]
  5. Froom P., Gross M., Ribak J., Barzilay J., Benbassat J. The effect of age on the prevalence of asymptomatic microscopic hematuria. Am J Clin Pathol. 1986 Nov;86(5):656–657. doi: 10.1093/ajcp/86.5.656. [DOI] [PubMed] [Google Scholar]
  6. Hirose K., Osterby R., Nozawa M., Gundersen H. J. Development of glomerular lesions in experimental long-term diabetes in the rat. Kidney Int. 1982 May;21(5):689–695. doi: 10.1038/ki.1982.82. [DOI] [PubMed] [Google Scholar]
  7. Jensen E. B., Gundersen H. J., Osterby R. Determination of membrane thickness distribution from orthogonal intercepts. J Microsc. 1979 Jan;115(1):19–33. doi: 10.1111/j.1365-2818.1979.tb00149.x. [DOI] [PubMed] [Google Scholar]
  8. McDowell E. M., Trump B. F. Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med. 1976 Aug;100(8):405–414. [PubMed] [Google Scholar]
  9. Mohr D. N., Offord K. P., Owen R. A., Melton L. J., 3rd Asymptomatic microhematuria and urologic disease. A population-based study. JAMA. 1986 Jul 11;256(2):224–229. [PubMed] [Google Scholar]
  10. Osterby R., Nyberg G., Andersson C., Frisk B. Glomerular structural quantities in baseline biopsies from cadaveric donor kidney pairs. APMIS Suppl. 1988;4:134–140. [PubMed] [Google Scholar]
  11. Piel C. F., Biava C. G., Goodman J. R. Glomerular basement membrane attenuation in familial nephritis and "benign" hematuria. J Pediatr. 1982 Sep;101(3):358–365. doi: 10.1016/s0022-3476(82)80058-9. [DOI] [PubMed] [Google Scholar]
  12. Rogers P. W., Kurtzman N. A., Bunn S. M., Jr, White M. G. Familial benign essential hematuria. Arch Intern Med. 1973 Feb;131(2):257–262. [PubMed] [Google Scholar]
  13. Steffes M. W., Barbosa J., Basgen J. M., Sutherland D. E., Najarian J. S., Mauer S. M. Quantitative glomerular morphology of the normal human kidney. Lab Invest. 1983 Jul;49(1):82–86. [PubMed] [Google Scholar]
  14. Tiebosch A. T., Frederik P. M., van Breda Vriesman P. J., Mooy J. M., van Rie H., van de Wiel T. W., Wolters J., Zeppenfeldt E. Thin-basement-membrane nephropathy in adults with persistent hematuria. N Engl J Med. 1989 Jan 5;320(1):14–18. doi: 10.1056/NEJM198901053200103. [DOI] [PubMed] [Google Scholar]
  15. Tiebosch A. T., Wolters J., Frederik P. F., van der Wiel T. W., Zeppenfeldt E., van Breda Vriesman P. J. Epidemiology of idiopathic glomerular disease: a prospective study. Kidney Int. 1987 Jul;32(1):112–116. doi: 10.1038/ki.1987.179. [DOI] [PubMed] [Google Scholar]
  16. Tina L., Jenis E., Jose P., Medani C., Papadopoulou Z., Calcagno P. The glomerular basement membrane in benign familial hematuria. Clin Nephrol. 1982 Jan;17(1):1–4. [PubMed] [Google Scholar]
  17. Yoshikawa N., Hashimoto H., Katayama Y., Yamada Y., Matsuo T., Okada S. The thin glomerular basement membrane in children with haematuria. J Pathol. 1984 Apr;142(4):253–257. doi: 10.1002/path.1711420403. [DOI] [PubMed] [Google Scholar]
  18. Yoshikawa N., White R. H., Cameron A. H. Familial hematuria; clinico-pathological correlations. Clin Nephrol. 1982 Apr;17(4):172–182. [PubMed] [Google Scholar]
  19. Yum M., Bergstein J. M. Basement membrane nephropathy: a new classification for Alport's syndrome and asymptomatic hematuria based on ultrastructural findings. Hum Pathol. 1983 Nov;14(11):996–1003. doi: 10.1016/s0046-8177(83)80180-4. [DOI] [PubMed] [Google Scholar]

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