Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1990 Dec;43(12):1004–1006. doi: 10.1136/jcp.43.12.1004

Type II oestrogen binding sites in human colorectal carcinoma.

M Piantelli 1, R Ricci 1, L M Larocca 1, A Rinelli 1, A Capelli 1, S Rizzo 1, G Scambia 1, F O Ranelletti 1
PMCID: PMC502973  PMID: 2266171

Abstract

Seven cases of colorectal adenocarcinomas were investigated for the presence of oestrogen receptors and progesterone receptors. The tumours specifically bound oestradiol. This binding almost exclusively resulted from the presence of high numbers of type II oestrogen binding sites. Oestrogen receptors were absent or present at very low concentrations. Immunohistochemical investigation of nuclear oestrogen receptors gave negative results. This indicates that antioestrogen receptor antibodies recognise oestrogen receptors but not type II oestrogen binding sites. The presence of specific type II oestrogen binding sites and progesterone binding offers further evidence for a potential role for these steroids and their receptors in colorectal carcinoma.

Full text

PDF
1005

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alford T. C., Do H. M., Geelhoed G. W., Tsangaris N. T., Lippman M. E. Steroid hormone receptors in human colon cancers. Cancer. 1979 Mar;43(3):980–984. doi: 10.1002/1097-0142(197903)43:3<980::aid-cncr2820430329>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  2. Berg J. W. Can nutrition explain the pattern of international epidemiology of hormone-dependent cancers? Cancer Res. 1975 Nov;35(11 Pt 2):3345–3350. [PubMed] [Google Scholar]
  3. Boctor A. M., Band P., Grossman A. Analysis of binding of [3H]Estradiol to the cytosol fraction of rat pancreas: comparison with sites in the cytosol of uterus. Endocrinology. 1983 Aug;113(2):453–462. doi: 10.1210/endo-113-2-453. [DOI] [PubMed] [Google Scholar]
  4. Carbone A., Ranelletti F. O., Rinelli A., Vecchio F. M., Lauriola L., Piantelli M., Capelli A. Type II estrogen receptors in the papillary cystic tumor of the pancreas. Am J Clin Pathol. 1989 Nov;92(5):572–576. doi: 10.1093/ajcp/92.5.572. [DOI] [PubMed] [Google Scholar]
  5. Clark J. H., Hardin J. W., Upchurch S., Eriksson H. Heterogeneity of estrogen binding sites in the cytosol of the rat uterus. J Biol Chem. 1978 Nov 10;253(21):7630–7634. [PubMed] [Google Scholar]
  6. Davis F. G., Furner S. E., Persky V., Koch M. The influence of parity and exogenous female hormones on the risk of colorectal cancer. Int J Cancer. 1989 Apr 15;43(4):587–590. doi: 10.1002/ijc.2910430409. [DOI] [PubMed] [Google Scholar]
  7. Dawson P. M., Shousha S., Blair S. D., Carter G. D., Jones J., Alaghband-Zadeh J., Theodorou N. A. Oestrogen receptors in colorectal carcinoma. J Clin Pathol. 1990 Feb;43(2):149–151. doi: 10.1136/jcp.43.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Francavilla A., Di Leo A., Polimeno L., Conte D., Barone M., Fanizza G., Chiumarulo C., Rizzo G., Rubino M. Nuclear and cytosolic estrogen receptors in human colon carcinoma and in surrounding noncancerous colonic tissue. Gastroenterology. 1987 Dec;93(6):1301–1306. doi: 10.1016/0016-5085(87)90259-9. [DOI] [PubMed] [Google Scholar]
  9. Herrmann J. B. Breast cancer and associated extramammary malignant neoplasms. Am J Surg. 1972 Nov;124(5):620–624. doi: 10.1016/0002-9610(72)90099-2. [DOI] [PubMed] [Google Scholar]
  10. Horwitz K. B., McGuire W. L. Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor. J Biol Chem. 1978 Apr 10;253(7):2223–2228. [PubMed] [Google Scholar]
  11. Larocca L. M., Piantelli M., Leone G., Sica S., Teofili L., Panici P. B., Scambia G., Mancuso S., Capelli A., Ranelletti F. O. Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids. Br J Haematol. 1990 Aug;75(4):489–495. doi: 10.1111/j.1365-2141.1990.tb07787.x. [DOI] [PubMed] [Google Scholar]
  12. Markaverich B. M., Clark J. H. Two binding sites for estradiol in rat uterine nuclei: relationship to uterotropic response. Endocrinology. 1979 Dec;105(6):1458–1462. doi: 10.1210/endo-105-6-1458. [DOI] [PubMed] [Google Scholar]
  13. Markaverich B. M., Williams M., Upchurch S., Clark J. H. Heterogeneity of nuclear estrogen-binding sites in the rat uterus: a simple method for the quantitation of type I and type II sites by [3H]estradiol exchange. Endocrinology. 1981 Jul;109(1):62–69. doi: 10.1210/endo-109-1-62. [DOI] [PubMed] [Google Scholar]
  14. McClendon J. E., Appleby D., Claudon D. B., Donegan W. L., DeCosse J. J. Colonic neoplasms: tissue estrogen receptor and carcinoembryonic antigen. Arch Surg. 1977 Mar;112(3):240–241. doi: 10.1001/archsurg.1977.01370030012002. [DOI] [PubMed] [Google Scholar]
  15. McMichael A. J., Potter J. D. Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. J Natl Cancer Inst. 1980 Dec;65(6):1201–1207. [PubMed] [Google Scholar]
  16. Panko W. B., Watson C. S., Clark J. H. The presence of a second, specific estrogen binding site in human breast cancer. J Steroid Biochem. 1981 Dec;14(12):1311–1316. doi: 10.1016/0022-4731(81)90337-x. [DOI] [PubMed] [Google Scholar]
  17. Panko W. B., Watson C. S., Clark J. H. The presence of a second, specific estrogen binding site in human breast cancer. J Steroid Biochem. 1981 Dec;14(12):1311–1316. doi: 10.1016/0022-4731(81)90337-x. [DOI] [PubMed] [Google Scholar]
  18. Ranelletti F. O., Piantelli M., Carbone A., Rinelli A., Scambia G., Panici P. B., Mancuso S. Type II estrogen-binding sites and 17 beta-hydroxysteroid dehydrogenase activity in human peripheral blood mononuclear cells. J Clin Endocrinol Metab. 1988 Nov;67(5):888–892. doi: 10.1210/jcem-67-5-888. [DOI] [PubMed] [Google Scholar]
  19. Salomaa S., Pekki A., Sannisto T., Ylikomi T., Tuohimaa P. Progesterone receptor is constitutively expressed in chicken intestinal mesothelium and smooth muscle. J Steroid Biochem. 1989;34(1-6):345–349. doi: 10.1016/0022-4731(89)90106-4. [DOI] [PubMed] [Google Scholar]
  20. Sica V., Nola E., Contieri E., Bova R., Masucci M. T., Medici N., Petrillo A., Weisz A., Molinari A. M., Puca G. A. Estradiol and progesterone receptors in malignant gastrointestinal tumors. Cancer Res. 1984 Oct;44(10):4670–4674. [PubMed] [Google Scholar]
  21. Syne J. S., Markaverich B. M., Clark J. H., Panko W. B. Estrogen binding sites in the nucleus of normal and malignant human tissue: characteristics of the multiple nuclear binding sites. Cancer Res. 1982 Nov;42(11):4449–4454. [PubMed] [Google Scholar]
  22. Thorlakson R. H. A set of double-angled needle holders and long, angled tissue forceps for use in surgery of the abdomen. Dis Colon Rectum. 1986 Sep;29(9):591–593. doi: 10.1007/BF02554268. [DOI] [PubMed] [Google Scholar]
  23. Wobbes T., Beex L. V., Koenders A. M. Estrogen and progestin receptors in colonic cancer? Dis Colon Rectum. 1984 Sep;27(9):591–592. doi: 10.1007/BF02553846. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES