Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1991 Feb;75(2):94–96. doi: 10.1136/bjo.75.2.94

Herpes simplex keratitis in renal transplant patients.

I Kremer 1, A Wagner 1, D Shmuel 1, A Yussim 1, Z Shapira 1
PMCID: PMC504122  PMID: 1995052

Abstract

Five out of 430 patients (1.16%) undergoing kidney transplantation developed an atypical clinical picture of herpetic dendritic keratitis within four weeks after surgery. It was manifested by multiple dendrites, located mainly in the corneal periphery or the limbus, developing in relatively uninflamed eyes. The response to acyclovir therapy was prolonged and took at least three weeks. Additionally, subepithelial infiltrates with ultimate scarring developed in all patients. Disciform keratopathy was not found. This clinical course is ascribed to the patients' immunosuppressed state.

Full text

PDF
94

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong J. A., Evans A. S., Rao N., Ho M. Viral infections in renal transplant recipients. Infect Immun. 1976 Oct;14(4):970–975. doi: 10.1128/iai.14.4.970-975.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cauda R., Citterio F., Tamburrini E., Pozzetto U., Tumbarello M., Castagneto M., Ortona L. Natural killer activity against viral targets in cyclosporine-treated renal allograft recipients. Transplant Proc. 1988 Apr;20(2 Suppl 2):186–189. [PubMed] [Google Scholar]
  3. Darougar S., Wishart M. S., Viswalingam N. D. Epidemiological and clinical features of primary herpes simplex virus ocular infection. Br J Ophthalmol. 1985 Jan;69(1):2–6. doi: 10.1136/bjo.69.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greenberg M. S., Friedman H., Cohen S. G., Oh S. H., Laster L., Starr S. A comparative study of herpes simplex infections in renal transplant and leukemic patients. J Infect Dis. 1987 Aug;156(2):280–287. doi: 10.1093/infdis/156.2.280. [DOI] [PubMed] [Google Scholar]
  5. Greger B., Döller G., Schareck W. D., Müller G. H., Mellert J., Hopt U. T., Bockhorn H. Incidence and clinical course of CMV- (and herpes simplex-) infections under triple drug therapy. Transplant Proc. 1987 Oct;19(5):4057–4060. [PubMed] [Google Scholar]
  6. Howcroft M. J., Breslin C. W. Herpes simplex keratitis in renal transplant recipients. Can Med Assoc J. 1981 Feb 1;124(3):292–294. [PMC free article] [PubMed] [Google Scholar]
  7. Kaufman H. E., Brown D. C., Ellison E. D. Herpes virus in the lacrimal gland, conjunctiva and cornea of man--a chronic infection. Am J Ophthalmol. 1968 Jan;65(1):32–35. doi: 10.1016/0002-9394(68)91024-6. [DOI] [PubMed] [Google Scholar]
  8. Korsager B., Spencer E. S., Mordhorst C. H., Andersen H. K. Herpesvirus hominis infections in renal transplant recipients. Scand J Infect Dis. 1975;7(1):11–19. doi: 10.3109/inf.1975.7.issue-1.03. [DOI] [PubMed] [Google Scholar]
  9. Metcalf J. F., Kaufman H. E. Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis. Am J Ophthalmol. 1976 Dec;82(6):827–834. doi: 10.1016/0002-9394(76)90057-x. [DOI] [PubMed] [Google Scholar]
  10. Mortensen K. K., Sjølie A. K. Keratitis dendritica. An epidemiological investigation. Acta Ophthalmol (Copenh) 1979 Oct;57(5):750–754. doi: 10.1111/j.1755-3768.1979.tb01840.x. [DOI] [PubMed] [Google Scholar]
  11. Naraqi S., Jackson G. G., Jonasson O., Yamashiroya H. M. Prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts. J Infect Dis. 1977 Oct;136(4):531–540. doi: 10.1093/infdis/136.4.531. [DOI] [PubMed] [Google Scholar]
  12. Naraqi S., Jonasson O., Jackson G. G., Yamashiroya H. M. Clinical manifestations of infections with herpesviruses after kidney transplantation: a prospective study of various syndromes. Ann Surg. 1978 Aug;188(2):234–239. doi: 10.1097/00000658-197808000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Norn M. S. Dendritic (herpetic) keratitis. I. Incidence--seasonal variations--recurrence rate--visual impairment--therapy. Acta Ophthalmol (Copenh) 1970;48(1):91–107. doi: 10.1111/j.1755-3768.1970.tb06577.x. [DOI] [PubMed] [Google Scholar]
  14. Pass R. F., Whitley R. J., Whelchel J. D., Diethelm A. G., Reynolds D. W., Alford C. A. Identification of patients with increased risk of infection with herpes simplex virus after renal transplantation. J Infect Dis. 1979 Oct;140(4):487–492. doi: 10.1093/infdis/140.4.487. [DOI] [PubMed] [Google Scholar]
  15. Pien F. D., Smith T. F., Anderson C. F., Webel M. L., Taswell H. F. Herpesviruses in renal transplant patients. Transplantation. 1973 Nov;16(5):489–495. doi: 10.1097/00007890-197311000-00014. [DOI] [PubMed] [Google Scholar]
  16. Rager-Zisman B., Allison A. C. Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection. J Immunol. 1976 Jan;116(1):35–40. [PubMed] [Google Scholar]
  17. Russell R. G., Nasisse M. P., Larsen H. S., Rouse B. T. Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest Ophthalmol Vis Sci. 1984 Aug;25(8):938–944. [PubMed] [Google Scholar]
  18. Schooley R. T., Hirsch M. S., Colvin R. B., Cosimi A. B., Tolkoff-Rubin N. E., McCluskey R. T., Burton R. C., Russell P. S., Herrin J. T., Delmonico F. L. Association of herpesvirus infections with T-lymphocyte-subset alterations, glomerulopathy, and opportunistic infections after renal transplantation. N Engl J Med. 1983 Feb 10;308(6):307–313. doi: 10.1056/NEJM198302103080603. [DOI] [PubMed] [Google Scholar]
  19. Takahashi K., Yagisawa T., Teraoka S., Toma H., Agishi T., Ota K., Kobayashi S. Viral infections in kidney transplant patients immunosuppressed with cyclosporine. Transplant Proc. 1987 Feb;19(1 Pt 3):2142–2149. [PubMed] [Google Scholar]
  20. Tullo A. B., Easty D. L., Shimeld C., Stirling P. E., Darville J. M. Isolation of herpes simplex virus from corneal discs of patients with chronic stromal keratitis. Trans Ophthalmol Soc U K. 1985;104(Pt 2):159–165. [PubMed] [Google Scholar]
  21. Whitcher J. P., Dawson C. R., Hoshiwara I., Daghfous T., Messadi M., Triki F., Oh J. O. Herpes simplex keratitis in a developing country. Natural history and treatment of epithelial ulcers in Tunisia. Arch Ophthalmol. 1976 Apr;94(4):587–592. doi: 10.1001/archopht.1976.03910030279006. [DOI] [PubMed] [Google Scholar]
  22. Whitley R. J., Levin M., Barton N., Hershey B. J., Davis G., Keeney R. E., Whelchel J., Diethelm A. G., Kartus P., Soong S. J. Infections caused by herpes simplex virus in the immunocompromised host: natural history and topical acyclovir therapy. J Infect Dis. 1984 Sep;150(3):323–329. doi: 10.1093/infdis/150.3.323. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES