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. 1992 Jan;76(1):39–42. doi: 10.1136/bjo.76.1.39

Spontaneous congenital non-pigmented epithelial cysts of the iris stroma.

A D Paridaens 1, K Deuble 1, A C McCartney 1
PMCID: PMC504147  PMID: 1739690

Abstract

Histopathological and immunohistochemical findings in 11 patients with spontaneous congenital non-pigmented epithelial cysts of the iris stroma were studied. The cysts were lined by stratified squamous to unilayered cuboidal non-pigmented epithelium. Goblet cells were present in nine cysts, indicating a similarity to conjunctival epithelium. The demonstration of higher-molecular-weight keratins and absence of S-100 protein, by monoclonal and polyclonal antibodies, argues for surface ectodermal rather than neuroectodermal origin of the cysts. Theories of embryogenesis have been conflicting, but our results support the theory that they arise from surface ectoderm, displaced probably at the time of lens vesicle formation. The finding of normally sited subepithelial S-100 positive melanocytes may suggest that ectopic conjunctival epithelium can induce normal patterns of migration of neural crest cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRUCE G. M. Aberrant glandular tissue in the iris. Trans Am Acad Ophthalmol Otolaryngol. 1952 Jan-Feb;56(1):47–51. [PubMed] [Google Scholar]
  2. Coburn A., Messmer E. P., Boniuk M., Font R. L. Spontaneous intrastromal iris cyst. A case report with immunohistochemical and ultrastructural observations. Ophthalmology. 1985 Dec;92(12):1691–1695. doi: 10.1016/s0161-6420(85)34093-9. [DOI] [PubMed] [Google Scholar]
  3. Corwin D. J., Gown A. M. Review of selected lineage-directed antibodies useful in routinely processed tissues. Arch Pathol Lab Med. 1989 Jun;113(6):645–652. [PubMed] [Google Scholar]
  4. Farmer S. G., Kalina R. E. Epithelial implantation cyst of the iris. Ophthalmology. 1981 Dec;88(12):1286–1289. doi: 10.1016/s0161-6420(81)34864-7. [DOI] [PubMed] [Google Scholar]
  5. GUERRY D., 3rd, WIESINGER H. Spontaneous cyst of the iris stroma. Am J Ophthalmol. 1957 Jul;44(1):106–107. doi: 10.1016/0002-9394(57)91962-1. [DOI] [PubMed] [Google Scholar]
  6. Grutzmacher R. D., Lindquist T. D., Chittum M. E., Bunt-Milam A. H., Kalina R. E. Congenital iris cysts. Br J Ophthalmol. 1987 Mar;71(3):227–234. doi: 10.1136/bjo.71.3.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hvidberg-Hansen J., Larsen F. E. Congenital iris cyst. A case studied by light and electron microscopy. Acta Ophthalmol (Copenh) 1972;50(4):501–514. doi: 10.1111/j.1755-3768.1972.tb05976.x. [DOI] [PubMed] [Google Scholar]
  8. KENNEDY P. J. Treatment of cysts of the iris with electrolysis. AMA Arch Ophthalmol. 1956 Apr;55(4):522–525. doi: 10.1001/archopht.1956.00930030526011. [DOI] [PubMed] [Google Scholar]
  9. KLIEN B. A., TANNER G. S. Congenital epithelial cyst of the iris stroma. Am J Ophthalmol. 1963 Feb;55:291–295. doi: 10.1016/0002-9394(63)92685-0. [DOI] [PubMed] [Google Scholar]
  10. POLITZER G. Die Entstehung der spontanen epithelialen Iriscysten. Albrecht Von Graefes Arch Ophthalmol. 1953;153(5-6):497–503. [PubMed] [Google Scholar]
  11. Roy F. H., Hanna C. Spontaneous congenital iris cyst. Am J Ophthalmol. 1971 Jul 30;72(1):97–108. doi: 10.1016/0002-9394(71)91596-0. [DOI] [PubMed] [Google Scholar]
  12. Rush J. A., Weinstein G. W., Meriwether W. A. Spontaneous nonpigmented iris cyst. Arch Ophthalmol. 1982 Feb;100(2):304–305. doi: 10.1001/archopht.1982.01030030306016. [DOI] [PubMed] [Google Scholar]
  13. Shields J. A., Kline M. W., Augsburger J. J. Primary iris cysts: a review of the literature and report of 62 cases. Br J Ophthalmol. 1984 Mar;68(3):152–166. doi: 10.1136/bjo.68.3.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sugar H. S., Nathan L. E. Congenital epithelial cysts of the iris stroma. Ann Ophthalmol. 1982 May;14(5):483–485. [PubMed] [Google Scholar]
  15. VAIL D. Treatment of cysts of the iris with diathermy coagulation. Am J Ophthalmol. 1954 Oct;38(4):513–518. doi: 10.1016/0002-9394(54)90702-3. [DOI] [PubMed] [Google Scholar]
  16. Waeltermann J. M., Hettinger M. E., Cibis G. W. Congenital cysts of the iris stroma. Am J Ophthalmol. 1985 Oct 15;100(4):549–554. doi: 10.1016/0002-9394(85)90680-4. [DOI] [PubMed] [Google Scholar]
  17. Witschel H., Berndt K., Mackensen G. Angeborene Stromazyste der Iris. Ein klinisch-histopathologischer Fallbericht. Klin Monbl Augenheilkd. 1979 Apr;174(4):572–576. [PubMed] [Google Scholar]

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