Abstract
The incidence of metastases to the uvea is compared with that in eight other (extraocular) target sites, in patients with metastatic primary carcinomas of the breast, colorectum, and lungs. The incidence of intraocular metastases from breast cancer is lower than in the eight other target organs surveyed; in the other primary cancers, the incidences were midway between those in the other sites, However, when the incidence of intraocular metastases is viewed in relation to the calculated numbers of cancer cells delivered via the arterial route, the uveal tract is the most highly favoured target site for the development of metastases per unit of delivered cancer cells.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ABRAMS H. L., SPIRO R., GOLDSTEIN N. Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer. 1950 Jan;3(1):74–85. doi: 10.1002/1097-0142(1950)3:1<74::aid-cncr2820030111>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- Alm A., Bill A., Young F. A. The effects of pilocarpine and neostigmine on the blood flow through the anterior uvea in monkeys. A study with radioactively labelled microspheres. Exp Eye Res. 1973 Jan 1;15(1):31–36. doi: 10.1016/0014-4835(73)90186-3. [DOI] [PubMed] [Google Scholar]
- Ferry A. P., Font R. L. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974 Oct;92(4):276–286. doi: 10.1001/archopht.1974.01010010286003. [DOI] [PubMed] [Google Scholar]
- Goldmann E. The Growth of Malignant Disease in Man and the Lower Animals, with special reference to the Vascular System. Proc R Soc Med. 1908;1(SURG):1–13. [PMC free article] [PubMed] [Google Scholar]
- Langham M. E., Kramer T. Decreased choroidal blood flow associated with retinitis pigmentosa. Eye (Lond) 1990;4(Pt 2):374–381. doi: 10.1038/eye.1990.50. [DOI] [PubMed] [Google Scholar]
- Merrill C. F., Kaufman D. I., Dimitrov N. V. Breast cancer metastatic to the eye is a common entity. Cancer. 1991 Aug 1;68(3):623–627. doi: 10.1002/1097-0142(19910801)68:3<623::aid-cncr2820680330>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
- Mewis L., Young S. E. Breast carcinoma metastatic to the choroid. Analysis of 67 patients. Ophthalmology. 1982 Feb;89(2):147–151. doi: 10.1016/s0161-6420(82)34838-1. [DOI] [PubMed] [Google Scholar]
- Nelson C. C., Hertzberg B. S., Klintworth G. K. A histopathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol. 1983 Jun;95(6):788–793. doi: 10.1016/0002-9394(83)90066-1. [DOI] [PubMed] [Google Scholar]
- Orenstein M. M., Anderson D. P., Stein J. J. Choroid metastasis. Cancer. 1972 Apr;29(4):1101–1107. doi: 10.1002/1097-0142(197204)29:4<1101::aid-cncr2820290460>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
- Stephens R. F., Shields J. A. Diagnosis and management of cancer metastatic to the uvea: a study of 70 cases. Ophthalmology. 1979 Jul;86(7):1336–1349. doi: 10.1016/s0161-6420(79)35393-3. [DOI] [PubMed] [Google Scholar]
- Weiss L. Comments on hematogenous metastatic patterns in humans as revealed by autopsy. Clin Exp Metastasis. 1992 May;10(3):191–199. doi: 10.1007/BF00132751. [DOI] [PubMed] [Google Scholar]
- Weiss L., Grundmann E., Torhorst J., Hartveit F., Moberg I., Eder M., Fenoglio-Preiser C. M., Napier J., Horne C. H., Lopez M. J. Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol. 1986 Nov;150(3):195–203. doi: 10.1002/path.1711500308. [DOI] [PubMed] [Google Scholar]
- Weiss L. Metastatic inefficiency. Adv Cancer Res. 1990;54:159–211. doi: 10.1016/s0065-230x(08)60811-8. [DOI] [PubMed] [Google Scholar]
- Weiss L., Ward P. M., Harlos J. P., Holmes J. C. Target organ patterns of tumors in mice following the arterial dissemination of B16 melanoma cells. Int J Cancer. 1984 Jun 15;33(6):825–830. doi: 10.1002/ijc.2910330618. [DOI] [PubMed] [Google Scholar]