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. 1993 Jun;77(6):354–357. doi: 10.1136/bjo.77.6.354

Lens opacities in neurofibromatosis 2: further significant correlations.

E A Bouzas 1, V Freidlin 1, D M Parry 1, R Eldridge 1, M I Kaiser-Kupfer 1
PMCID: PMC504529  PMID: 8318482

Abstract

This prospective study of 96 individuals from 29 families with neurofibromatosis 2, 49 of whom were affected, confirms in an extended series the previously reported association between posterior subcapsular/capsular cataract and neurofibromatosis 2. Posterior subcapsular/capsular cataracts were found in 36 (80%) of the 45 affected individuals (four individuals were excluded from statistical analyses). In addition, the association of peripheral cortical lens opacities with neurofibromatosis 2 was found to be statistically significant. Seventeen of the patients with neurofibromatosis 2 (37.8%) had peripheral cortical cataracts in comparison with none of the unaffected family members (p < 0.0001). In three patients peripheral cortical opacities were present despite the absence of posterior subcapsular/capsular cataracts. These findings support the inclusion of cortical cataracts of early onset, in addition to posterior subcapsular/capsular cataracts, in the diagnostic criteria of neurofibromatosis 2.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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