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. 1994 Jan;78(1):30–32. doi: 10.1136/bjo.78.1.30

Influence of apraclonidine and pilocarpine alone and in combination on post laser trabeculoplasty pressure rise.

R B Dapling 1, I A Cunliffe 1, S Longstaff 1
PMCID: PMC504686  PMID: 7906539

Abstract

Apraclonidine and pilocarpine have been shown to be effective in reducing the incidence of intraocular pressure (IOP) spikes following argon laser trabeculoplasty. An additional reduction in the incidence of acute pressure rise might theoretically be expected by combining these two effective agents. In a prospective randomised study we compared the ability of apraclonidine and pilocarpine alone and in combination to prevent post laser pressure spikes. Patients receiving regular pilocarpine to either eye were excluded. Seventy five eyes received either apraclonidine (26 eyes), pilocarpine (23 eyes), or both drugs (26 eyes). Apraclonidine 1% was instilled 1 hour before and immediately after, and pilocarpine 4% immediately after trabeculoplasty. IOP was measured before and at 1, 2, and 3 hours following trabeculoplasty. In only two (8%) eyes receiving combined treatment was a pressure rise observed. This frequency was significantly lower than that seen in eyes treated with apraclonidine alone (38%), or pilocarpine alone (39%). The mean fall in IOP at 1, 2, and 3 hours was significantly greater in those eyes receiving combined treatment than in the other two groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balkan R. J., Zimmerman T. J., Hesse R. J., Steigner J. B. Loss of central visual acuity after laser peripheral iridectomy. Ann Ophthalmol. 1982 Aug;14(8):721–723. [PubMed] [Google Scholar]
  2. Blackwell C., Hirst L. W., Kinnas S. J. Neodymium-YAG capsulotomy and potential blindness. Am J Ophthalmol. 1984 Oct 15;98(4):521–522. doi: 10.1016/0002-9394(84)90149-1. [DOI] [PubMed] [Google Scholar]
  3. Brooks A. M., Elder J., McNab A. A., McCombe M. F., Madhok P., Gillies W. E. Preventing a high rise in intraocular pressure after laser trabeculoplasty. Aust N Z J Ophthalmol. 1987 May;15(2):113–117. doi: 10.1111/j.1442-9071.1987.tb00055.x. [DOI] [PubMed] [Google Scholar]
  4. Brown R. H., Stewart R. H., Lynch M. G., Crandall A. S., Mandell A. I., Wilensky J. T., Schwartz A. L., Gaasterland D. E., DeFaller J. M., Higginbotham E. J. ALO 2145 reduces the intraocular pressure elevation after anterior segment laser surgery. Ophthalmology. 1988 Mar;95(3):378–384. doi: 10.1016/s0161-6420(88)33185-4. [DOI] [PubMed] [Google Scholar]
  5. Hoskins H. D., Jr, Hetherington J., Jr, Minckler D. S., Lieberman M. F., Shaffer R. N. Complications of laser trabeculoplasty. Ophthalmology. 1983 Jul;90(7):796–799. doi: 10.1016/s0161-6420(83)34485-7. [DOI] [PubMed] [Google Scholar]
  6. Krupin T., Kolker A. E., Kass M. A., Becker B. Intraocular pressure the day of argon laser trabeculoplasty in primary open-angle glaucoma. Ophthalmology. 1984 Apr;91(4):361–365. doi: 10.1016/s0161-6420(84)34279-8. [DOI] [PubMed] [Google Scholar]
  7. Leung K. W., Gillies W. E. The detection and management of the acute rise in intraocular pressure following laser trabeculoplasty. Aust N Z J Ophthalmol. 1986 Aug;14(3):259–262. doi: 10.1111/j.1442-9071.1986.tb00046.x. [DOI] [PubMed] [Google Scholar]
  8. Odberg T. Primary argon laser trabeculoplasty after pretreatment with timolol. A safe and economic therapy of early glaucoma. Acta Ophthalmol (Copenh) 1990 Jun;68(3):317–319. doi: 10.1111/j.1755-3768.1990.tb01929.x. [DOI] [PubMed] [Google Scholar]
  9. Ofner S., Samples J. R., van Buskirk E. M. Pilocarpine and the increase in intraocular pressure after trabeculoplasty. Am J Ophthalmol. 1984 May;97(5):647–649. doi: 10.1016/0002-9394(84)90390-8. [DOI] [PubMed] [Google Scholar]
  10. Robin A. L. Argon laser trabeculoplasty medical therapy to prevent the intraocular pressure rise associated with argon laser trabeculoplasty. Ophthalmic Surg. 1991 Jan;22(1):31–37. [PubMed] [Google Scholar]
  11. Robin A. L., Pollack I. P., House B., Enger C. Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty. Arch Ophthalmol. 1987 May;105(5):646–650. doi: 10.1001/archopht.1987.01060050064039. [DOI] [PubMed] [Google Scholar]
  12. Thomas J. V., Simmons R. J., Belcher C. D., 3rd Argon laser trabeculoplasty in the presurgical glaucoma patient. Ophthalmology. 1982 Mar;89(3):187–197. doi: 10.1016/s0161-6420(82)34807-1. [DOI] [PubMed] [Google Scholar]
  13. Vine A. K. Ocular hypertension following Nd:YAG laser capsulotomy: a potentially blinding complication. Ophthalmic Surg. 1984 Apr;15(4):283–284. [PubMed] [Google Scholar]
  14. Weinreb R. N., Ruderman J., Juster R., Zweig K. Immediate intraocular pressure response to argon laser trabeculoplasty. Am J Ophthalmol. 1983 Mar;95(3):279–286. doi: 10.1016/s0002-9394(14)78294-7. [DOI] [PubMed] [Google Scholar]

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