Skip to main content
NCBI home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1994 Sep;78(9):698–701. doi: 10.1136/bjo.78.9.698

Unilateral retinoblastoma: new intraocular tumours after treatment.

D H Abramson 1, L S Gamell 1, R M Ellsworth 1, E F Kruger 1, C A Servodidio 1, L Turner 1, D Sussman 1
PMCID: PMC504909  PMID: 7947551

Abstract

A retrospective chart review of 427 eyes diagnosed with unilateral retinoblastoma was performed to determine which eyes, which patients, and when new intraocular tumours would develop after treatment. Mean follow up was 8.16 years. Twenty five (6%) of 427 unilateral retinoblastoma patients developed new intraocular tumours after treatment. Five (1%) unilateral patients who were previously treated with enucleation developed new tumours (in the fellow eye). Fifteen (24%) unilateral patients who were previously treated with external beam radiation developed new tumours (equally in either eye). New tumours did not develop in the macula of either eye. The relative risk of developing new intraocular tumours after treatment was 16% in patients diagnosed before 1 year old and 2.2% for patients diagnosed after 1 year old (p < 0.001). The mean time to onset for the development of new tumours after treatment was 0.74 years; no new tumours appeared after 7.5 years of age. Those patients who are diagnosed with unilateral retinoblastoma in the first 6 months of life and have a family history of the disease are at greatest risk of developing new intraocular tumours.

Full text

PDF
698

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abramson D. H., Ellsworth R. M., Grumbach N., Kitchin F. D. Retinoblastoma: survival, age at detection and comparison 1914-1958, 1958-1983. J Pediatr Ophthalmol Strabismus. 1985 Nov-Dec;22(6):246–250. doi: 10.3928/0191-3913-19851101-11. [DOI] [PubMed] [Google Scholar]
  2. Abramson D. H., Ellsworth R. M., Grumbach N., Sturgis-Buckhout L., Haik B. G. Retinoblastoma: correlation between age at diagnosis and survival. J Pediatr Ophthalmol Strabismus. 1986 Jul-Aug;23(4):174–177. doi: 10.3928/0191-3913-19860701-06. [DOI] [PubMed] [Google Scholar]
  3. Abramson D. H., Ellsworth R. M., Kitchin F. D., Tung G. Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced? Ophthalmology. 1984 Nov;91(11):1351–1355. doi: 10.1016/s0161-6420(84)34127-6. [DOI] [PubMed] [Google Scholar]
  4. Abramson D. H., Greenfield D. S., Ellsworth R. M. Bilateral retinoblastoma. Correlations between age at diagnosis and time course for new intraocular tumors. Ophthalmic Paediatr Genet. 1992 Mar;13(1):1–7. doi: 10.3109/13816819209070046. [DOI] [PubMed] [Google Scholar]
  5. Abramson D. H., Marks R. F., Ellsworth R. M., Tretter P., Kitchin F. D. The management of unilateral retinoblastoma without primary enucleation. Arch Ophthalmol. 1982 Aug;100(8):1249–1252. doi: 10.1001/archopht.1982.01030040227002. [DOI] [PubMed] [Google Scholar]
  6. Abramson D. H., Notterman R. B., Ellsworth R. M., Kitchin F. D. Retinoblastoma treated in infants in the first six months of life. Arch Ophthalmol. 1983 Sep;101(9):1362–1366. doi: 10.1001/archopht.1983.01040020364004. [DOI] [PubMed] [Google Scholar]
  7. Abramson D. H. The diagnosis of retinoblastoma. Bull N Y Acad Med. 1988 May;64(4):283–317. [PMC free article] [PubMed] [Google Scholar]
  8. Abramson D. H. The focal treatment of retinoblastoma with emphasis on xenon arc photocoagulation. Acta Ophthalmol Suppl. 1989;194:3–63. [PubMed] [Google Scholar]
  9. Ehlers N., Kaae S. Effects of ionizing radiation on retinoblastoma and on the normal ocular fundus in infants. A photographic and fluorescein angiographic study. Acta Ophthalmol Suppl. 1987;181:3–84. [PubMed] [Google Scholar]
  10. Gallie B. L., Dunn J. M., Chan H. S., Hamel P. A., Phillips R. A. The genetics of retinoblastoma. Relevance to the patient. Pediatr Clin North Am. 1991 Apr;38(2):299–315. doi: 10.1016/s0031-3955(16)38079-8. [DOI] [PubMed] [Google Scholar]
  11. Rubenfeld M., Abramson D. H., Ellsworth R. M., Kitchin F. D. Unilateral vs. bilateral retinoblastoma. Correlations between age at diagnosis and stage of ocular disease. Ophthalmology. 1986 Aug;93(8):1016–1019. doi: 10.1016/s0161-6420(86)33629-7. [DOI] [PubMed] [Google Scholar]
  12. Salmonsen P. C., Ellsworth R. M., Kitchin F. D. The occurrence of new retinoblastomas after treatment. Ophthalmology. 1979 May;86(5):837–843. doi: 10.1016/s0161-6420(79)35469-0. [DOI] [PubMed] [Google Scholar]
  13. Shields C. L., Shields J. A., Shah P. Retinoblastoma in older children. Ophthalmology. 1991 Mar;98(3):395–399. doi: 10.1016/s0161-6420(91)32283-8. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES