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. 1996 Jan 15;97(2):275–280. doi: 10.1172/JCI118413

Biological insights through genomics: mouse to man.

E M Rubin 1, G S Barsh 1
PMCID: PMC507015  PMID: 8567945

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Selected References

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  1. ALONSO L. G., MAREN T. H. Effect of food restriction on body composition of hereditary obese mice. Am J Physiol. 1955 Nov;183(2):284–290. doi: 10.1152/ajplegacy.1955.183.2.284. [DOI] [PubMed] [Google Scholar]
  2. Adams M. D., Soares M. B., Kerlavage A. R., Fields C., Venter J. C. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Nat Genet. 1993 Aug;4(4):373–380. doi: 10.1038/ng0893-373. [DOI] [PubMed] [Google Scholar]
  3. Ajioka J. W., Smoller D. A., Jones R. W., Carulli J. P., Vellek A. E., Garza D., Link A. J., Duncan I. W., Hartl D. L. Drosophila genome project: one-hit coverage in yeast artificial chromosomes. Chromosoma. 1991 Sep;100(8):495–509. doi: 10.1007/BF00352200. [DOI] [PubMed] [Google Scholar]
  4. BATES M. W., NAUSS S. F., HAGMAN N. C., MAYER J. Fat metabolism in three forms of experimental obesity; body composition. Am J Physiol. 1955 Feb;180(2):301–303. doi: 10.1152/ajplegacy.1955.180.2.301. [DOI] [PubMed] [Google Scholar]
  5. Bahary N., Siegel D. A., Walsh J., Zhang Y., Leopold L., Leibel R., Proenca R., Friedman J. M. Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation. Mamm Genome. 1993 Sep;4(9):511–515. doi: 10.1007/BF00364786. [DOI] [PubMed] [Google Scholar]
  6. Bellanné-Chantelot C., Lacroix B., Ougen P., Billault A., Beaufils S., Bertrand S., Georges I., Glibert F., Gros I., Lucotte G. Mapping the whole human genome by fingerprinting yeast artificial chromosomes. Cell. 1992 Sep 18;70(6):1059–1068. doi: 10.1016/0092-8674(92)90254-a. [DOI] [PubMed] [Google Scholar]
  7. Bouchard C. Genetic factors in obesity. Med Clin North Am. 1989 Jan;73(1):67–81. doi: 10.1016/s0025-7125(16)30692-7. [DOI] [PubMed] [Google Scholar]
  8. Bultman S. J., Michaud E. J., Woychik R. P. Molecular characterization of the mouse agouti locus. Cell. 1992 Dec 24;71(7):1195–1204. doi: 10.1016/s0092-8674(05)80067-4. [DOI] [PubMed] [Google Scholar]
  9. Bultman S. J., Russell L. B., Gutierrez-Espeleta G. A., Woychik R. P. Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse. Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8062–8066. doi: 10.1073/pnas.88.18.8062. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Burke D. T., Carle G. F., Olson M. V. Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science. 1987 May 15;236(4803):806–812. doi: 10.1126/science.3033825. [DOI] [PubMed] [Google Scholar]
  11. CARPENTER K. J., MAYER J. Physiologic observations on yellow obesity in the mouse. Am J Physiol. 1958 Jun;193(3):499–504. doi: 10.1152/ajplegacy.1958.193.3.499. [DOI] [PubMed] [Google Scholar]
  12. Cai H., Kiefel P., Yee J., Duncan I. A yeast artificial chromosome clone map of the Drosophila genome. Genetics. 1994 Apr;136(4):1385–1399. doi: 10.1093/genetics/136.4.1385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Callow M. J., Stoltzfus L. J., Lawn R. M., Rubin E. M. Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2130–2134. doi: 10.1073/pnas.91.6.2130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Chlouverakis C. Effect of caloric restriction on body weight loss and body fat utilization in obese hyperglycemic mice (obob). Metabolism. 1972 Jan;21(1):10–17. doi: 10.1016/0026-0495(72)90015-7. [DOI] [PubMed] [Google Scholar]
  15. Chlouverakis C. Induction of obesity in obese-hyperglycaemic mice on normal food intake. Experientia. 1970 Nov 15;26(11):1262–1263. doi: 10.1007/BF01898005. [DOI] [PubMed] [Google Scholar]
  16. Chumakov I., Rigault P., Guillou S., Ougen P., Billaut A., Guasconi G., Gervy P., LeGall I., Soularue P., Grinas L. Continuum of overlapping clones spanning the entire human chromosome 21q. Nature. 1992 Oct 1;359(6394):380–387. doi: 10.1038/359380a0. [DOI] [PubMed] [Google Scholar]
  17. Cohen D., Chumakov I., Weissenbach J. A first-generation physical map of the human genome. Nature. 1993 Dec 16;366(6456):698–701. doi: 10.1038/366698a0. [DOI] [PubMed] [Google Scholar]
  18. Cohen J. C., Chiesa G., Hobbs H. H. Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels. J Clin Invest. 1993 Apr;91(4):1630–1636. doi: 10.1172/JCI116370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Coleman D. L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973 Aug;9(4):294–298. doi: 10.1007/BF01221857. [DOI] [PubMed] [Google Scholar]
  20. Coleman D. L., Hummel K. P. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol. 1969 Nov;217(5):1298–1304. doi: 10.1152/ajplegacy.1969.217.5.1298. [DOI] [PubMed] [Google Scholar]
  21. Copeland N. G., Jenkins N. A., Gilbert D. J., Eppig J. T., Maltais L. J., Miller J. C., Dietrich W. F., Weaver A., Lincoln S. E., Steen R. G. A genetic linkage map of the mouse: current applications and future prospects. Science. 1993 Oct 1;262(5130):57–66. doi: 10.1126/science.8211130. [DOI] [PubMed] [Google Scholar]
  22. Coulson A., Kozono Y., Lutterbach B., Shownkeen R., Sulston J., Waterston R. YACs and the C. elegans genome. Bioessays. 1991 Aug;13(8):413–417. doi: 10.1002/bies.950130809. [DOI] [PubMed] [Google Scholar]
  23. Crossley M., Orkin S. H. Regulation of the beta-globin locus. Curr Opin Genet Dev. 1993 Apr;3(2):232–237. doi: 10.1016/0959-437x(93)90028-n. [DOI] [PubMed] [Google Scholar]
  24. DICKIES M. M. A new viable yellow mutation in the house mouse. J Hered. 1962 Mar-Apr;53:84–86. doi: 10.1093/oxfordjournals.jhered.a107129. [DOI] [PubMed] [Google Scholar]
  25. Davisson M. T., Schmidt C., Reeves R. H., Irving N. G., Akeson E. C., Harris B. S., Bronson R. T. Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117–133. [PubMed] [Google Scholar]
  26. Dickerson G. E., Gowen J. W. Hereditary Obesity and Efficient Food Utilization in Mice. Science. 1947 May 9;105(2732):496–498. doi: 10.1126/science.105.2732.496-a. [DOI] [PubMed] [Google Scholar]
  27. Dickie M. M. Mutations at the agouti locus in the mouse. J Hered. 1969 Jan-Feb;60(1):20–25. doi: 10.1093/oxfordjournals.jhered.a107920. [DOI] [PubMed] [Google Scholar]
  28. Dietrich W., Katz H., Lincoln S. E., Shin H. S., Friedman J., Dracopoli N. C., Lander E. S. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 1992 Jun;131(2):423–447. doi: 10.1093/genetics/131.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Duhl D. M., Stevens M. E., Vrieling H., Saxon P. J., Miller M. W., Epstein C. J., Barsh G. S. Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Development. 1994 Jun;120(6):1695–1708. doi: 10.1242/dev.120.6.1695. [DOI] [PubMed] [Google Scholar]
  30. Duhl D. M., Vrieling H., Miller K. A., Wolff G. L., Barsh G. S. Neomorphic agouti mutations in obese yellow mice. Nat Genet. 1994 Sep;8(1):59–65. doi: 10.1038/ng0994-59. [DOI] [PubMed] [Google Scholar]
  31. Edwardson J. A., Hough C. A. The pituitary-adrenal system of the genetically obese (ob/ob) mouse. J Endocrinol. 1975 Apr;65(1):99–107. doi: 10.1677/joe.0.0650099. [DOI] [PubMed] [Google Scholar]
  32. Foote S., Vollrath D., Hilton A., Page D. C. The human Y chromosome: overlapping DNA clones spanning the euchromatic region. Science. 1992 Oct 2;258(5079):60–66. doi: 10.1126/science.1359640. [DOI] [PubMed] [Google Scholar]
  33. Frazer K. A., Narla G., Zhang J. L., Rubin E. M. The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice. Nat Genet. 1995 Apr;9(4):424–431. doi: 10.1038/ng0495-424. [DOI] [PubMed] [Google Scholar]
  34. Friedman J. M., Leibel R. L., Siegel D. S., Walsh J., Bahary N. Molecular mapping of the mouse ob mutation. Genomics. 1991 Dec;11(4):1054–1062. doi: 10.1016/0888-7543(91)90032-a. [DOI] [PubMed] [Google Scholar]
  35. Gaensler K. M., Kitamura M., Kan Y. W. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11381–11385. doi: 10.1073/pnas.90.23.11381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Garthwaite T. L., Martinson D. R., Tseng L. F., Hagen T. C., Menahan L. A. A longitudinal hormonal profile of the genetically obese mouse. Endocrinology. 1980 Sep;107(3):671–676. doi: 10.1210/endo-107-3-671. [DOI] [PubMed] [Google Scholar]
  37. Garza D., Ajioka J. W., Burke D. T., Hartl D. L. Mapping the Drosophila genome with yeast artificial chromosomes. Science. 1989 Nov 3;246(4930):641–646. doi: 10.1126/science.2510296. [DOI] [PubMed] [Google Scholar]
  38. Geschwind I. I. Change in hair color in mice induced by injection of alpha-MSH. Endocrinology. 1966 Dec;79(6):1165–1167. doi: 10.1210/endo-79-6-1165. [DOI] [PubMed] [Google Scholar]
  39. HOLLIFIELD G., PARSON W. Food drive and satiety in yellow mice. Am J Physiol. 1957 Apr;189(1):36–38. doi: 10.1152/ajplegacy.1957.189.1.36. [DOI] [PubMed] [Google Scholar]
  40. Ioannou P. A., Amemiya C. T., Garnes J., Kroisel P. M., Shizuya H., Chen C., Batzer M. A., de Jong P. J. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nat Genet. 1994 Jan;6(1):84–89. doi: 10.1038/ng0194-84. [DOI] [PubMed] [Google Scholar]
  41. Jackson E., Stolz D., Martin R. Effect of adrenalectomy on weight gain and body composition of yellow obese mice (Ay/a). Horm Metab Res. 1976 Nov;8(6):452–455. doi: 10.1055/s-0028-1093612. [DOI] [PubMed] [Google Scholar]
  42. Korenberg J. R., Chen X. N., Schipper R., Sun Z., Gonsky R., Gerwehr S., Carpenter N., Daumer C., Dignan P., Disteche C. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4997–5001. doi: 10.1073/pnas.91.11.4997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Kusumi K., Smith J. S., Segre J. A., Koos D. S., Lander E. S. Construction of a large-insert yeast artificial chromosome library of the mouse genome. Mamm Genome. 1993;4(7):391–392. doi: 10.1007/BF00360591. [DOI] [PubMed] [Google Scholar]
  44. LANE P. W., DICKIE M. M. The effect of restricted food intake on the life span of genetically obese mice. J Nutr. 1958 Apr 10;64(4):549–554. doi: 10.1093/jn/64.4.549. [DOI] [PubMed] [Google Scholar]
  45. Lamb B. T., Sisodia S. S., Lawler A. M., Slunt H. H., Kitt C. A., Kearns W. G., Pearson P. L., Price D. L., Gearhart J. D. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet. 1993 Sep;5(1):22–30. doi: 10.1038/ng0993-22. [DOI] [PubMed] [Google Scholar]
  46. Leibel R. L., Rosenbaum M., Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 1995 Mar 9;332(10):621–628. doi: 10.1056/NEJM199503093321001. [DOI] [PubMed] [Google Scholar]
  47. Lichtman S. W., Pisarska K., Berman E. R., Pestone M., Dowling H., Offenbacher E., Weisel H., Heshka S., Matthews D. E., Heymsfield S. B. Discrepancy between self-reported and actual caloric intake and exercise in obese subjects. N Engl J Med. 1992 Dec 31;327(27):1893–1898. doi: 10.1056/NEJM199212313272701. [DOI] [PubMed] [Google Scholar]
  48. Lin P. Y., Romsos D. R., Leveille G. A. Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse. J Nutr. 1977 Sep;107(9):1715–1723. doi: 10.1093/jn/107.9.1715. [DOI] [PubMed] [Google Scholar]
  49. Linton M. F., Farese R. V., Jr, Chiesa G., Grass D. S., Chin P., Hammer R. E., Hobbs H. H., Young S. G. Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). J Clin Invest. 1993 Dec;92(6):3029–3037. doi: 10.1172/JCI116927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Lu D., Willard D., Patel I. R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R. P., Wilkison W. O. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature. 1994 Oct 27;371(6500):799–802. doi: 10.1038/371799a0. [DOI] [PubMed] [Google Scholar]
  51. Meade C. J., Ashwell M., Sowter C. Is genetically transmitted obesity due to an adipose tissue defect? Proc R Soc Lond B Biol Sci. 1979 Aug 31;205(1160):395–410. doi: 10.1098/rspb.1979.0073. [DOI] [PubMed] [Google Scholar]
  52. Michaud E. J., Bultman S. J., Klebig M. L., van Vugt M. J., Stubbs L. J., Russell L. B., Woychik R. P. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2562–2566. doi: 10.1073/pnas.91.7.2562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Miller M. W., Duhl D. M., Vrieling H., Cordes S. P., Ollmann M. M., Winkes B. M., Barsh G. S. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 1993 Mar;7(3):454–467. doi: 10.1101/gad.7.3.454. [DOI] [PubMed] [Google Scholar]
  54. Murray J. C., Buetow K. H., Weber J. L., Ludwigsen S., Scherpbier-Heddema T., Manion F., Quillen J., Sheffield V. C., Sunden S., Duyk G. M. A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC). Science. 1994 Sep 30;265(5181):2049–2054. doi: 10.1126/science.8091227. [DOI] [PubMed] [Google Scholar]
  55. Naeser P. Effects of adrenalectomy on the obese-hyperglycemic syndrome in mice (gene symbol ob). Diabetologia. 1973 Oct;9(5):376–379. doi: 10.1007/BF01239430. [DOI] [PubMed] [Google Scholar]
  56. Peterson K. R., Clegg C. H., Huxley C., Josephson B. M., Haugen H. S., Furukawa T., Stamatoyannopoulos G. Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7593–7597. doi: 10.1073/pnas.90.16.7593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Pierce J. C., Sauer B., Sternberg N. A positive selection vector for cloning high molecular weight DNA by the bacteriophage P1 system: improved cloning efficacy. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2056–2060. doi: 10.1073/pnas.89.6.2056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Rahmani Z., Blouin J. L., Creau-Goldberg N., Watkins P. C., Mattei J. F., Poissonnier M., Prieur M., Chettouh Z., Nicole A., Aurias A. Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5958–5962. doi: 10.1073/pnas.86.15.5958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Robbins L. S., Nadeau J. H., Johnson K. R., Kelly M. A., Roselli-Rehfuss L., Baack E., Mountjoy K. G., Cone R. D. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell. 1993 Mar 26;72(6):827–834. doi: 10.1016/0092-8674(93)90572-8. [DOI] [PubMed] [Google Scholar]
  60. Shimizu H., Shargill N. S., Bray G. A. Adrenalectomy and response to corticosterone and MSH in the genetically obese yellow mouse. Am J Physiol. 1989 Feb;256(2 Pt 2):R494–R500. doi: 10.1152/ajpregu.1989.256.2.R494. [DOI] [PubMed] [Google Scholar]
  61. Shizuya H., Birren B., Kim U. J., Mancino V., Slepak T., Tachiiri Y., Simon M. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8794–8797. doi: 10.1073/pnas.89.18.8794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Smith D. J., Zhu Y., Zhang J., Cheng J. F., Rubin E. M. Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425–434. doi: 10.1006/geno.1995.1073. [DOI] [PubMed] [Google Scholar]
  63. Solomon J., Mayer J. The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome in ob-ob mice. Endocrinology. 1973 Aug;93(2):510–512. doi: 10.1210/endo-93-2-510. [DOI] [PubMed] [Google Scholar]
  64. Tokunaga K., Fukushima M., Lupien J. R., Bray G. A., Kemnitz J. W., Schemmel R. Effects of food restriction and adrenalectomy in rats with VMH or PVH lesions. Physiol Behav. 1989 Jun;45(6):1131–1137. doi: 10.1016/0031-9384(89)90099-1. [DOI] [PubMed] [Google Scholar]
  65. Utermann G. The mysteries of lipoprotein(a). Science. 1989 Nov 17;246(4932):904–910. doi: 10.1126/science.2530631. [DOI] [PubMed] [Google Scholar]
  66. Vilberg T. R., Keesey R. E. Reduced energy expenditure after ventromedial hypothalamic lesions in female rats. Am J Physiol. 1984 Jul;247(1 Pt 2):R183–R188. doi: 10.1152/ajpregu.1984.247.1.R183. [DOI] [PubMed] [Google Scholar]
  67. Vrieling H., Duhl D. M., Millar S. E., Miller K. A., Barsh G. S. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5667–5671. doi: 10.1073/pnas.91.12.5667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. WOLFF G. L. GROWTH OF INBRED YELLOW (AYA) AND NON-YELLOW (AA) MICE IN PARABIOSIS. Genetics. 1963 Aug;48:1041–1058. doi: 10.1093/genetics/48.8.1041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Watson J. D., Cook-Deegan R. M. Origins of the Human Genome Project. FASEB J. 1991 Jan;5(1):8–11. doi: 10.1096/fasebj.5.1.1991595. [DOI] [PubMed] [Google Scholar]
  70. Westman S. Development of the obese-hyperglycaemic syndrome in mice. Diabetologia. 1968 Jun;4(3):141–149. doi: 10.1007/BF01219435. [DOI] [PubMed] [Google Scholar]
  71. Wilson B. D., Ollmann M. M., Kang L., Stoffel M., Bell G. I., Barsh G. S. Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet. 1995 Feb;4(2):223–230. doi: 10.1093/hmg/4.2.223. [DOI] [PubMed] [Google Scholar]
  72. Wolff G. L., Flack J. D. Genetic regulation of plasma corticosterone concentration and its response to castration and allogeneic tumour growth in the mouse. Nat New Biol. 1971 Aug 11;232(2):181–182. doi: 10.1038/newbio232181a0. [DOI] [PubMed] [Google Scholar]
  73. Wolff G. L., Roberts D. W., Galbraith D. B. Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome. J Hered. 1986 May-Jun;77(3):151–158. doi: 10.1093/oxfordjournals.jhered.a110206. [DOI] [PubMed] [Google Scholar]
  74. Woychik R. P., Generoso W. M., Russell L. B., Cain K. T., Cacheiro N. L., Bultman S. J., Selby P. B., Dickinson M. E., Hogan B. L., Rutledge J. C. Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2588–2592. doi: 10.1073/pnas.87.7.2588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994 Dec 1;372(6505):425–432. doi: 10.1038/372425a0. [DOI] [PubMed] [Google Scholar]

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