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. 1997 Jul 1;100(1):1–5. doi: 10.1172/JCI119500

Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology.

S J Shattil 1, M H Ginsberg 1
PMCID: PMC508157  PMID: 9202049

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Selected References

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  1. Allen W. E., Jones G. E., Pollard J. W., Ridley A. J. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci. 1997 Mar;110(Pt 6):707–720. doi: 10.1242/jcs.110.6.707. [DOI] [PubMed] [Google Scholar]
  2. Assoian R. K., Zhu X. Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression. Curr Opin Cell Biol. 1997 Feb;9(1):93–98. doi: 10.1016/s0955-0674(97)80157-3. [DOI] [PubMed] [Google Scholar]
  3. Baker E. K., Tozer E. C., Pfaff M., Shattil S. J., Loftus J. C., Ginsberg M. H. A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1973–1978. doi: 10.1073/pnas.94.5.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Berditchevski F., Bazzoni G., Hemler M. E. Specific association of CD63 with the VLA-3 and VLA-6 integrins. J Biol Chem. 1995 Jul 28;270(30):17784–17790. doi: 10.1074/jbc.270.30.17784. [DOI] [PubMed] [Google Scholar]
  5. Berditchevski F., Tolias K. F., Wong K., Carpenter C. L., Hemler M. E. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997 Jan 31;272(5):2595–2598. doi: 10.1074/jbc.272.5.2595. [DOI] [PubMed] [Google Scholar]
  6. Berlin C., Berg E. L., Briskin M. J., Andrew D. P., Kilshaw P. J., Holzmann B., Weissman I. L., Hamann A., Butcher E. C. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993 Jul 16;74(1):185–195. doi: 10.1016/0092-8674(93)90305-a. [DOI] [PubMed] [Google Scholar]
  7. Boudreau N., Myers C., Bissell M. J. From laminin to lamin: regulation of tissue-specific gene expression by the ECM. Trends Cell Biol. 1995 Jan;5(1):1–4. doi: 10.1016/s0962-8924(00)88924-2. [DOI] [PubMed] [Google Scholar]
  8. Burridge K., Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol. 1996;12:463–518. doi: 10.1146/annurev.cellbio.12.1.463. [DOI] [PubMed] [Google Scholar]
  9. Chen Y. P., O'Toole T. E., Shipley T., Forsyth J., LaFlamme S. E., Yamada K. M., Shattil S. J., Ginsberg M. H. "Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem. 1994 Jul 15;269(28):18307–18310. [PubMed] [Google Scholar]
  10. Clark E. A., Brugge J. S. Integrins and signal transduction pathways: the road taken. Science. 1995 Apr 14;268(5208):233–239. doi: 10.1126/science.7716514. [DOI] [PubMed] [Google Scholar]
  11. Coppolino M. G., Woodside M. J., Demaurex N., Grinstein S., St-Arnaud R., Dedhar S. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature. 1997 Apr 24;386(6627):843–847. doi: 10.1038/386843a0. [DOI] [PubMed] [Google Scholar]
  12. Coppolino M., Leung-Hagesteijn C., Dedhar S., Wilkins J. Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrin. J Biol Chem. 1995 Sep 29;270(39):23132–23138. doi: 10.1074/jbc.270.39.23132. [DOI] [PubMed] [Google Scholar]
  13. Dedhar S., Hannigan G. E. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol. 1996 Oct;8(5):657–669. doi: 10.1016/s0955-0674(96)80107-4. [DOI] [PubMed] [Google Scholar]
  14. Eigenthaler M., Höfferer L., Shattil S. J., Ginsberg M. H. A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin. J Biol Chem. 1997 Mar 21;272(12):7693–7698. doi: 10.1074/jbc.272.12.7693. [DOI] [PubMed] [Google Scholar]
  15. Faull R. J., Kovach N. L., Harlan J. M., Ginsberg M. H. Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin. J Cell Biol. 1993 Apr;121(1):155–162. doi: 10.1083/jcb.121.1.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Guan J. L., Trevithick J. E., Hynes R. O. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul. 1991 Nov;2(11):951–964. doi: 10.1091/mbc.2.11.951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hannigan G. E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M. G., Radeva G., Filmus J., Bell J. C., Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature. 1996 Jan 4;379(6560):91–96. doi: 10.1038/379091a0. [DOI] [PubMed] [Google Scholar]
  18. Horwitz A., Duggan K., Buck C., Beckerle M. C., Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986 Apr 10;320(6062):531–533. doi: 10.1038/320531a0. [DOI] [PubMed] [Google Scholar]
  19. Hotchin N. A., Hall A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol. 1995 Dec;131(6 Pt 2):1857–1865. doi: 10.1083/jcb.131.6.1857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hughes P. E., Diaz-Gonzalez F., Leong L., Wu C., McDonald J. A., Shattil S. J., Ginsberg M. H. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem. 1996 Mar 22;271(12):6571–6574. doi: 10.1074/jbc.271.12.6571. [DOI] [PubMed] [Google Scholar]
  21. Hughes P. E., O'Toole T. E., Ylänne J., Shattil S. J., Ginsberg M. H. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem. 1995 May 26;270(21):12411–12417. doi: 10.1074/jbc.270.21.12411. [DOI] [PubMed] [Google Scholar]
  22. Hughes P. E., Renshaw M. W., Pfaff M., Forsyth J., Keivens V. M., Schwartz M. A., Ginsberg M. H. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell. 1997 Feb 21;88(4):521–530. doi: 10.1016/s0092-8674(00)81892-9. [DOI] [PubMed] [Google Scholar]
  23. Hynes R. O. Targeted mutations in cell adhesion genes: what have we learned from them? Dev Biol. 1996 Dec 15;180(2):402–412. doi: 10.1006/dbio.1996.0314. [DOI] [PubMed] [Google Scholar]
  24. Ingber D. E. Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol. 1997;59:575–599. doi: 10.1146/annurev.physiol.59.1.575. [DOI] [PubMed] [Google Scholar]
  25. Juliano R. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. Bioessays. 1996 Nov;18(11):911–917. doi: 10.1002/bies.950181110. [DOI] [PubMed] [Google Scholar]
  26. Kashiwagi H., Schwartz M. A., Eigenthaler M., Davis K. A., Ginsberg M. H., Shattil S. J. Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. J Cell Biol. 1997 Jun 16;137(6):1433–1443. doi: 10.1083/jcb.137.6.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Kawaguchi S., Bergelson J. M., Finberg R. W., Hemler M. E. Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol Biol Cell. 1994 Sep;5(9):977–988. doi: 10.1091/mbc.5.9.977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Kieffer J. D., Plopper G., Ingber D. E., Hartwig J. H., Kupper T. S. Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem Biophys Res Commun. 1995 Dec 14;217(2):466–474. doi: 10.1006/bbrc.1995.2799. [DOI] [PubMed] [Google Scholar]
  29. Knezevic I., Leisner T. M., Lam S. C. Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3. J Biol Chem. 1996 Jul 5;271(27):16416–16421. doi: 10.1074/jbc.271.27.16416. [DOI] [PubMed] [Google Scholar]
  30. Kolanus W., Nagel W., Schiller B., Zeitlmann L., Godar S., Stockinger H., Seed B. Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell. 1996 Jul 26;86(2):233–242. doi: 10.1016/s0092-8674(00)80095-1. [DOI] [PubMed] [Google Scholar]
  31. LaFlamme S. E., Thomas L. A., Yamada S. S., Yamada K. M. Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly. J Cell Biol. 1994 Sep;126(5):1287–1298. doi: 10.1083/jcb.126.5.1287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Lauffenburger D. A., Horwitz A. F. Cell migration: a physically integrated molecular process. Cell. 1996 Feb 9;84(3):359–369. doi: 10.1016/s0092-8674(00)81280-5. [DOI] [PubMed] [Google Scholar]
  33. Lee J. O., Rieu P., Arnaout M. A., Liddington R. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell. 1995 Feb 24;80(4):631–638. doi: 10.1016/0092-8674(95)90517-0. [DOI] [PubMed] [Google Scholar]
  34. Leong L., Hughes P. E., Schwartz M. A., Ginsberg M. H., Shattil S. J. Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. J Cell Sci. 1995 Dec;108(Pt 12):3817–3825. doi: 10.1242/jcs.108.12.3817. [DOI] [PubMed] [Google Scholar]
  35. Li S., Couet J., Lisanti M. P. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 1996 Nov 15;271(46):29182–29190. doi: 10.1074/jbc.271.46.29182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Lindberg F. P., Bullard D. C., Caver T. E., Gresham H. D., Beaudet A. L., Brown E. J. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science. 1996 Nov 1;274(5288):795–798. doi: 10.1126/science.274.5288.795. [DOI] [PubMed] [Google Scholar]
  37. Lollo B. A., Chan K. W., Hanson E. M., Moy V. T., Brian A. A. Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells. J Biol Chem. 1993 Oct 15;268(29):21693–21700. [PubMed] [Google Scholar]
  38. Lukashev M. E., Sheppard D., Pytela R. Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain. J Biol Chem. 1994 Jul 15;269(28):18311–18314. [PubMed] [Google Scholar]
  39. McKay B. S., Annis D. S., Honda S., Christie D., Kunicki T. J. Molecular requirements for assembly and function of a minimized human integrin alphaIIbbeta3. J Biol Chem. 1996 Nov 29;271(48):30544–30547. doi: 10.1074/jbc.271.48.30544. [DOI] [PubMed] [Google Scholar]
  40. McNamee H. P., Ingber D. E., Schwartz M. A. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol. 1993 May;121(3):673–678. doi: 10.1083/jcb.121.3.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Meacci E., Tsai S. C., Adamik R., Moss J., Vaughan M. Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1745–1748. doi: 10.1073/pnas.94.5.1745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Miyamoto S., Teramoto H., Gutkind J. S., Yamada K. M. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol. 1996 Dec;135(6 Pt 1):1633–1642. doi: 10.1083/jcb.135.6.1633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Mobley J. L., Ennis E., Shimizu Y. Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function. J Immunol. 1996 Feb 1;156(3):948–956. [PubMed] [Google Scholar]
  44. Naik U. P., Patel P. M., Parise L. V. Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem. 1997 Feb 21;272(8):4651–4654. doi: 10.1074/jbc.272.8.4651. [DOI] [PubMed] [Google Scholar]
  45. Nobes C. D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995 Apr 7;81(1):53–62. doi: 10.1016/0092-8674(95)90370-4. [DOI] [PubMed] [Google Scholar]
  46. O'Toole T. E., Katagiri Y., Faull R. J., Peter K., Tamura R., Quaranta V., Loftus J. C., Shattil S. J., Ginsberg M. H. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 1994 Mar;124(6):1047–1059. doi: 10.1083/jcb.124.6.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. O'Toole T. E., Ylanne J., Culley B. M. Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain. J Biol Chem. 1995 Apr 14;270(15):8553–8558. doi: 10.1074/jbc.270.15.8553. [DOI] [PubMed] [Google Scholar]
  48. Opas M., Szewczenko-Pawlikowski M., Jass G. K., Mesaeli N., Michalak M. Calreticulin modulates cell adhesiveness via regulation of vinculin expression. J Cell Biol. 1996 Dec;135(6 Pt 2):1913–1923. doi: 10.1083/jcb.135.6.1913. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Otey C. A., Vasquez G. B., Burridge K., Erickson B. W. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. J Biol Chem. 1993 Oct 5;268(28):21193–21197. [PubMed] [Google Scholar]
  50. Palecek S. P., Loftus J. C., Ginsberg M. H., Lauffenburger D. A., Horwitz A. F. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature. 1997 Feb 6;385(6616):537–540. doi: 10.1038/385537a0. [DOI] [PubMed] [Google Scholar]
  51. Qu A., Leahy D. J. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure. 1996 Aug 15;4(8):931–942. doi: 10.1016/s0969-2126(96)00100-1. [DOI] [PubMed] [Google Scholar]
  52. Reszka A. A., Hayashi Y., Horwitz A. F. Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association. J Cell Biol. 1992 Jun;117(6):1321–1330. doi: 10.1083/jcb.117.6.1321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Rosales C., O'Brien V., Kornberg L., Juliano R. Signal transduction by cell adhesion receptors. Biochim Biophys Acta. 1995 Jul 28;1242(1):77–98. doi: 10.1016/0304-419x(95)00005-z. [DOI] [PubMed] [Google Scholar]
  54. Rubinstein E., Le Naour F., Lagaudrière-Gesbert C., Billard M., Conjeaud H., Boucheix C. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur J Immunol. 1996 Nov;26(11):2657–2665. doi: 10.1002/eji.1830261117. [DOI] [PubMed] [Google Scholar]
  55. Sastry S. K., Horwitz A. F. Adhesion-growth factor interactions during differentiation: an integrated biological response. Dev Biol. 1996 Dec 15;180(2):455–467. doi: 10.1006/dbio.1996.0319. [DOI] [PubMed] [Google Scholar]
  56. Schaller M. D., Otey C. A., Hildebrand J. D., Parsons J. T. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol. 1995 Sep;130(5):1181–1187. doi: 10.1083/jcb.130.5.1181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Schwartz M. A., Schaller M. D., Ginsberg M. H. Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol. 1995;11:549–599. doi: 10.1146/annurev.cb.11.110195.003001. [DOI] [PubMed] [Google Scholar]
  58. Sharma C. P., Ezzell R. M., Arnaout M. A. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J Immunol. 1995 Apr 1;154(7):3461–3470. [PubMed] [Google Scholar]
  59. Shattil S. J., O'Toole T., Eigenthaler M., Thon V., Williams M., Babior B. M., Ginsberg M. H. Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol. 1995 Nov;131(3):807–816. doi: 10.1083/jcb.131.3.807. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Slupsky J. R., Kamiguti A. S., Rhodes N. P., Cawley J. C., Shaw A. R., Zuzel M. The platelet antigens CD9, CD42 and integrin alpha IIb beta IIIa can be topographically associated and transduce functionally similar signals. Eur J Biochem. 1997 Feb 15;244(1):168–175. doi: 10.1111/j.1432-1033.1997.00168.x. [DOI] [PubMed] [Google Scholar]
  61. Springer T. A. Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):65–72. doi: 10.1073/pnas.94.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Sundberg C., Rubin K. Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors. J Cell Biol. 1996 Feb;132(4):741–752. doi: 10.1083/jcb.132.4.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Tanaka T., Yamaguchi R., Sabe H., Sekiguchi K., Healy J. M. Paxillin association in vitro with integrin cytoplasmic domain peptides. FEBS Lett. 1996 Dec 9;399(1-2):53–58. doi: 10.1016/s0014-5793(96)01280-x. [DOI] [PubMed] [Google Scholar]
  64. Tapon N., Hall A. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol. 1997 Feb;9(1):86–92. doi: 10.1016/s0955-0674(97)80156-1. [DOI] [PubMed] [Google Scholar]
  65. Tozer E. C., Liddington R. C., Sutcliffe M. J., Smeeton A. H., Loftus J. C. Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit. J Biol Chem. 1996 Sep 6;271(36):21978–21984. doi: 10.1074/jbc.271.36.21978. [DOI] [PubMed] [Google Scholar]
  66. Wary K. K., Mainiero F., Isakoff S. J., Marcantonio E. E., Giancotti F. G. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell. 1996 Nov 15;87(4):733–743. doi: 10.1016/s0092-8674(00)81392-6. [DOI] [PubMed] [Google Scholar]
  67. Weber C., Alon R., Moser B., Springer T. A. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J Cell Biol. 1996 Aug;134(4):1063–1073. doi: 10.1083/jcb.134.4.1063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Wu C., Keivens V. M., O'Toole T. E., McDonald J. A., Ginsberg M. H. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell. 1995 Dec 1;83(5):715–724. doi: 10.1016/0092-8674(95)90184-1. [DOI] [PubMed] [Google Scholar]
  69. Yamada K. M., Geiger B. Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol. 1997 Feb;9(1):76–85. doi: 10.1016/s0955-0674(97)80155-x. [DOI] [PubMed] [Google Scholar]
  70. Ylänne J., Chen Y., O'Toole T. E., Loftus J. C., Takada Y., Ginsberg M. H. Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol. 1993 Jul;122(1):223–233. doi: 10.1083/jcb.122.1.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Ylänne J., Huuskonen J., O'Toole T. E., Ginsberg M. H., Virtanen I., Gahmberg C. G. Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. J Biol Chem. 1995 Apr 21;270(16):9550–9557. doi: 10.1074/jbc.270.16.9550. [DOI] [PubMed] [Google Scholar]
  72. Zhou M., Brown E. J. Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst. J Exp Med. 1993 Oct 1;178(4):1165–1174. doi: 10.1084/jem.178.4.1165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Zhu Q., Zelinka P., White T., Tanzer M. L. Calreticulin-integrin bidirectional signaling complex. Biochem Biophys Res Commun. 1997 Mar 17;232(2):354–358. doi: 10.1006/bbrc.1997.6195. [DOI] [PubMed] [Google Scholar]
  74. van Kooyk Y., Figdor C. G. Activation and inactivation of adhesion molecules. Curr Top Microbiol Immunol. 1993;184:235–256. doi: 10.1007/978-3-642-78253-4_19. [DOI] [PubMed] [Google Scholar]

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