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. 1991 Jan 15;88(2):557–560. doi: 10.1073/pnas.88.2.557

A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.

R Delgado 1, P Hidalgo 1, F Diaz 1, R Latorre 1, P Labarca 1
PMCID: PMC50850  PMID: 1846445

Abstract

Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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