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. 1991 Apr 15;88(8):3057–3059. doi: 10.1073/pnas.88.8.3057

Metalloselenonein, the selenium analogue of metallothionein: synthesis and characterization of its complex with copper ions.

T Oikawa 1, N Esaki 1, H Tanaka 1, K Soda 1
PMCID: PMC51383  PMID: 1826562

Abstract

We used an automated peptide synthesizer to produce a peptide, metalloselenonein, that contains selenocysteine residues substituted for all cysteine residues in Neurospora crassa copper metallothionein. Metalloselenonein binds 3 mol of Cu(I) per mol. This adduct shows a broad absorption band between 230 and 400 nm and a fluorescence band at 395 nm, which can be attributed to copper-selenolate coordination. The circular dichroism spectrum of the copper-metalloselenonein complex shows a positive band around 245 nm attributable to asymmetry in metal coordination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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