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. 1976 Apr;18(1):1–6. doi: 10.1128/jvi.18.1.1-6.1976

DNA polymerase activities induced by polyoma virus infection of 3T3 mouse fibroblasts.

M Närkhammar, G Magnusson
PMCID: PMC515514  PMID: 176454

Abstract

Resting mouse 3T3 fibroblasts were stimulated to synthesize DNA either by infection with polyoma virus or by injection of fresh serum. Changes in the levels of DNA polymerase (alpha-, beta-, and gamma-enzymes) were measured in the cytoplasm and the cell nucleus. Both types of stimulation gave very similar increases for all three enzyme activities. In the cell nucleus, both alpha- and gamma-polymerases increased almost tenfold, whereas the beta-enzyme only was stimulated twofold. In the cytoplasm alpha- and gamma-polymerases increased two- to four-fold. Only insignificant amounts of the beta-enzyme were found in the cytoplasm.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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