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. 1976 Apr;18(1):34–41. doi: 10.1128/jvi.18.1.34-41.1976

Proteins solubilized from frog virus 3 particles: effect on transcription.

A M Aubertin, C Travo, A Kirn
PMCID: PMC515518  PMID: 1255875

Abstract

The treatment of KB cells with viral proteins solubilized from frog virus 3 particles (SVE) induced a rapid shutoff of host RNA synthesis. The RNA polymerase activities of SVE-treated cells were drastically depressed, corresonding, at least for RNA polymerase B, to a decrease in the number of enzyme molecules. In vitro, SVE had no direct effect on RNA polymerases but was capable of binding with calf thymus DNA to form an SVE-DNA complex modifying the template capacity. The effect of SVE on a transcription system consisting of cell lysates would suggest that cytoplasmic factors are necessary for expression of the inhibitory capacity of SVE.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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