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. 1976 Apr;18(1):65–70. doi: 10.1128/jvi.18.1.65-70.1976

UV sensitivity of a nonrepressor regulatory protein of bacteriophage P22.

S I Tokuno, M Gough
PMCID: PMC515522  PMID: 768525

Abstract

The product of phage P22 gene c1 has two functions: it promotes synthesis of P22 repressor and it retards expression of some lytic genes. We present evidence that this product is inactivated in UV-irradiated hosts. The conditions for inactivation of c1 product include a functional DNA recombination system involving the host recA gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Botstein D., Herskowitz I. Properties of hybrids between Salmonella phage P22 and coliphage lambda. Nature. 1974 Oct 18;251(5476):584–589. doi: 10.1038/251584a0. [DOI] [PubMed] [Google Scholar]
  2. Bronson M. J., Levine M. Virulent mutants of phage P22. II. Physiological analysis of P22 virB-3 and its component mutations. Virology. 1972 Mar;47(3):644–655. doi: 10.1016/0042-6822(72)90554-5. [DOI] [PubMed] [Google Scholar]
  3. Court D., Green L., Echols H. Positive and negative regulation by the cII and cIII gene products of bacteriophage lambda. Virology. 1975 Feb;63(2):484–491. doi: 10.1016/0042-6822(75)90321-9. [DOI] [PubMed] [Google Scholar]
  4. Echols H. Developmental pathways for the temperate phage: lysis vs lysogeny,. Annu Rev Genet. 1972;6(0):157–190. doi: 10.1146/annurev.ge.06.120172.001105. [DOI] [PubMed] [Google Scholar]
  5. FRY B. A. Conditions for the infection of Escherichia coli with lambda phage and for the establishment of lysogeny. J Gen Microbiol. 1959 Dec;21:676–684. doi: 10.1099/00221287-21-3-676. [DOI] [PubMed] [Google Scholar]
  6. Gough M., Tokuno S. Further structural and functional analogies between the repressor regions of phages P22 and lambda. Mol Gen Genet. 1975;138(1):71–79. doi: 10.1007/BF00268829. [DOI] [PubMed] [Google Scholar]
  7. Hong J. S., Smith G. R., Ames B. N. Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2258–2262. doi: 10.1073/pnas.68.9.2258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LEVINE M. Mutations in the temperate phage P22 and lysogeny in Salmonella. Virology. 1957 Feb;3(1):22–41. doi: 10.1016/0042-6822(57)90021-1. [DOI] [PubMed] [Google Scholar]
  9. LIEB M. The establishment of lysogenicity in Escherichia coli. J Bacteriol. 1953 Jun;65(6):642–651. doi: 10.1128/jb.65.6.642-651.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Levine M., Schott C. Mutations of phage P22 affecting phage DNA synthesis and lysogenization. J Mol Biol. 1971 Nov 28;62(1):53–64. doi: 10.1016/0022-2836(71)90130-6. [DOI] [PubMed] [Google Scholar]
  11. Roberts J. W., Roberts C. W. Proteolytic cleavage of bacteriophage lambda repressor in induction. Proc Natl Acad Sci U S A. 1975 Jan;72(1):147–151. doi: 10.1073/pnas.72.1.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SMITH H. O., LEVINE M. TWO SEQUENTIAL REPRESSIONS OF DNA SYNTHESIS IN THE ESTABLISHMENT OF LYSOGENY BY PHAGE P22 AND ITS MUTANTS. Proc Natl Acad Sci U S A. 1964 Aug;52:356–363. doi: 10.1073/pnas.52.2.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Shinagawa H., Ito T. Inactivation of DNA-binding activity of repressor in extracts of lambda-lysogen treated with mitomycin C. Mol Gen Genet. 1973 Nov 2;126(2):103–110. doi: 10.1007/BF00330987. [DOI] [PubMed] [Google Scholar]
  14. Steinberg B., Gough M. Altered DNA synthesis in a mutant of Salmonella typhimurium that channels bacteriophage P22 toward lysogeny. J Virol. 1975 Nov;16(5):1154–1160. doi: 10.1128/jvi.16.5.1154-1160.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Steinberg R. A., Ptashne M. In vitro repression of RNA synthesis by purified lambda phage repressor. Nat New Biol. 1971 Mar 17;230(11):76–80. doi: 10.1038/newbio230076a0. [DOI] [PubMed] [Google Scholar]
  16. Sussman R., Zeev H. B. Proposed mechanism of bacteriophage lambda induction: acquisition of binding sites for lambda repressor by DNA of the host. Proc Natl Acad Sci U S A. 1975 May;72(5):1973–1976. doi: 10.1073/pnas.72.5.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tokuno S. I., Goldschmidt E. P., Gough M. Mutant of Salmonella typhimurium that channels infecting bacteriophage P22 toward lysogenization. J Bacteriol. 1974 Aug;119(2):508–513. doi: 10.1128/jb.119.2.508-513.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tokuno S. I., Gough M. Host influence on the activity of genes c1 and c3 in regulating the decision between lysis and lysogency in bacteriophage P22. J Virol. 1975 Nov;16(5):1184–1190. doi: 10.1128/jvi.16.5.1184-1190.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tomizawa J., Ogawa T. Effect of ultraviolet irradiation on bacteriophage lambda immunity. J Mol Biol. 1967 Jan 28;23(2):247–263. doi: 10.1016/s0022-2836(67)80031-7. [DOI] [PubMed] [Google Scholar]
  20. Wing J. P. Integration and induction of phage P22 in a recombination-deficient mutant of Salmonella typhimurium. J Virol. 1968 Jul;2(7):702–709. doi: 10.1128/jvi.2.7.702-709.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]

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