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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1991 May 1;88(9):3932–3936. doi: 10.1073/pnas.88.9.3932

Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.

C J Luneau 1, J B Williams 1, J Marshall 1, E S Levitan 1, C Oliva 1, J S Smith 1, J Antanavage 1, K Folander 1, R B Stein 1, R Swanson 1, et al.
PMCID: PMC51567  PMID: 2023941

Abstract

In an attempt to define the molecular basis of the functional diversity of K+ channels, we have isolated overlapping rat brain cDNAs that encoded a neuronal delayed rectifier K+ channel, K,4, that is structurally related to the Drosophila Shaw protein. Unlike previously characterized mammalian K+ channel genes, which each contain a single protein-coding exon, K,4 arises from alternative exon usage at a locus that also encodes another mammalian Shaw homolog, NGK2. Thus, the enormous diversity of K+ channels in mammals can be generated not just through gene duplication and divergence but also through alternative splicing of RNA.

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