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. 1977 Nov;24(2):551–556. doi: 10.1128/jvi.24.2.551-556.1977

Characterization of Gazdar murine sarcoma virus by nucleic acid hybridization and analysis of viral expression in cells.

R H Pang, L A Phillips, D K Haapala
PMCID: PMC515966  PMID: 199741

Abstract

Gazdar murine sarcoma virus (Gz-MSV) and Moloney murine sarcoma virus (M-MSV) are closely related. The complete M-MSV-specific nucleic acid sequences constituted a major portion of Gz-MSV-specific sequences. The MSV-specific sequences in both Gz-MSV and M-MSV genomes shared homology with hamster leukemia virus nucleic acid sequences. Both rat cells (S+L+) and hamster (S+L-) cells expressed two viral proteins of 68,000 and 70,000 daltons. These proteins were immunologically related to p60 purified from m1 virions of M-MSV.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Frankel A. E., Neubauer R. L., Fischinger P. J. Fractionation of DNA nucleotide transcripts from Moloney sarcoma virus and isolation of sarcoma virus-specific complementary DNA. J Virol. 1976 May;18(2):481–490. doi: 10.1128/jvi.18.2.481-490.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gazdar A. F., Beitzel W., Talal N. The age related responses of New Zealand mice to a murine sarcoma virus. Clin Exp Immunol. 1971 Mar;8(3):501–509. [PMC free article] [PubMed] [Google Scholar]
  3. Gazdar A. F., Sarma P. S., Bassin R. H. Properties of a murine sarcoma virus isolated from a tumor arising in an NZW-NZB F 1 hybrid mouse. II. Physical and biological characteristics. Int J Cancer. 1972 Jan 15;9(1):234–241. doi: 10.1002/ijc.2910090125. [DOI] [PubMed] [Google Scholar]
  4. HARVEY J. J. AN UNIDENTIFIED VIRUS WHICH CAUSES THE RAPID PRODUCTION OF TUMOURS IN MICE. Nature. 1964 Dec 12;204:1104–1105. doi: 10.1038/2041104b0. [DOI] [PubMed] [Google Scholar]
  5. Jamjoom G., Karshin W. L., Naso R. B., Arcement L. J., Arlinghaus R. B. Proteins of Rauscher murine leukemia virus: resolution of a 70,000-dalton, Nonglycosylated polypeptide containing p30 peptide sequences. Virology. 1975 Nov;68(1):135–145. doi: 10.1016/0042-6822(75)90155-5. [DOI] [PubMed] [Google Scholar]
  6. Leong J. A., Garapin A. C., Jackson N., Fanshier L., Levinson W., Bishop J. M. Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization. J Virol. 1972 Jun;9(6):891–902. doi: 10.1128/jvi.9.6.891-902.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Moloney J. B. A virus-induced rhabdomyosarcoma of mice. Natl Cancer Inst Monogr. 1966 Sep;22:139–142. [PubMed] [Google Scholar]
  8. Okabe H., Gilden R. V., Hatanaka M. Specificity of the DNA product of RNA-dependent DNA polymerase in type C viruses: 3. Analysis of viruses derived from Syrian hamsters. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3278–3282. doi: 10.1073/pnas.71.8.3278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Peebles P. T., Fischinger P. J., Bassin R. H., Papageorge A. G. Isolation of human amnion cells transformed by rescuable murine sarcoma virus. Nat New Biol. 1973 Mar 28;242(117):98–101. doi: 10.1038/newbio242098a0. [DOI] [PubMed] [Google Scholar]
  10. Phillips L. A., Hollis V. W., Jr, Bassin R. H., Fischinger P. J. Characterization of RNA from noninfectious virions produced by sarcoma positive-leukemia negative transformed 3T3 cells. Proc Natl Acad Sci U S A. 1973 Oct;70(10):3002–3006. doi: 10.1073/pnas.70.10.3002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Robey W. G., Oskarsson M. K., Vande Woude G. F., Naso R. B., Arlinghaus R. B., Haapala D. K., Fischinger P. J. Cells transformed by certain strains of Moloney sarcoma virus contain murine p60. Cell. 1977 Jan;10(1):79–89. doi: 10.1016/0092-8674(77)90142-8. [DOI] [PubMed] [Google Scholar]
  12. Scolnick E. M., Parks W. P. Harvey sarcoma virus: a second murine type C sarcoma virus with rat genetic information. J Virol. 1974 Jun;13(6):1211–1219. doi: 10.1128/jvi.13.6.1211-1219.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scolnick E. M., Rands E., Williams D., Parks W. P. Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus. J Virol. 1973 Sep;12(3):458–463. doi: 10.1128/jvi.12.3.458-463.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Zaanie D., Gielkens A. L., Dekker-michielsen M. J., Bloemers H. P. Virus-specific precursor polypeptides in cells infected with Rauscher leukemia virus. Virology. 1975 Oct;67(2):544–552. doi: 10.1016/0042-6822(75)90454-7. [DOI] [PubMed] [Google Scholar]

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