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. 1991 Oct 15;88(20):9026–9030. doi: 10.1073/pnas.88.20.9026

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

W Matthews 1, C T Jordan 1, M Gavin 1, N A Jenkins 1, N G Copeland 1, I R Lemischka 1
PMCID: PMC52644  PMID: 1717995

Abstract

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

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Selected References

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