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. 1991 Nov 15;88(22):10138–10142. doi: 10.1073/pnas.88.22.10138

Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.

P Leroy 1, H Nakshatri 1, P Chambon 1
PMCID: PMC52883  PMID: 1658797

Abstract

We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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