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. 1991 Dec 15;88(24):11067–11070. doi: 10.1073/pnas.88.24.11067

Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

J A Cassill 1, M Whitney 1, C A Joazeiro 1, A Becker 1, C S Zuker 1
PMCID: PMC53074  PMID: 1662381

Abstract

G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein kinases that appear to code for G protein-coupled receptor kinases. These proteins share a high degree of sequence homology with the bovine beta-adrenergic receptor kinase. The presence of a conserved family of G protein-coupled receptor kinases in vertebrates and invertebrates points to the central role of these kinases in signal transduction cascades.

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