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Journal of the Royal College of Physicians of London logoLink to Journal of the Royal College of Physicians of London
. 1996 Mar-Apr;30(2):122–127.

The Diagnosis of Epilepsies

R A Grünewald 1, C P Panayiotopoulos 2
PMCID: PMC5401546  PMID: 8709057

Abstract

Vague labels such as 'epilepsy', 'grand mal' or 'seizures' are detrimental to patient care, and should be universally abandoned in favour of the syndromic diagnosis of epilepsies.

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Contributor Information

R A Grünewald, Clinical Lecturer in Neurology, University of Sheffield, Royal Hallamshire Hospital, Sheffield.

C P Panayiotopoulos, Department of Clinical Neurophysiology and Epilepsies, St Thomas' Hospital, London.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. doi: 10.1016/0140-6736(92)90667-r. [DOI] [PubMed] [Google Scholar]
  2. doi: 10.1016/0140-6736(90)91815-r. [DOI] [PubMed] [Google Scholar]
  3. doi: 10.1111/j.1528-1157.1989.tb05316.x. [DOI] [PubMed] [Google Scholar]
  4. doi: 10.1093/brain/112.4.1039. [DOI] [PubMed] [Google Scholar]
  5. doi: 10.1038/337647a0. [DOI] [PubMed] [Google Scholar]
  6. doi: 10.1002/ajmg.1320310125. [DOI] [PubMed] [Google Scholar]
  7. doi: 10.1111/j.1469-8749.1977.tb08015.x. [DOI] [PubMed] [Google Scholar]
  8. doi: 10.1111/j.1528-1157.1981.tb06159.x. [DOI] [PubMed] [Google Scholar]
  9. doi: 10.1111/j.1469-8749.1995.tb11978.x. [DOI] [PubMed] [Google Scholar]
  10. doi: 10.1111/j.1528-1157.1994.tb02549.x. [DOI] [PubMed] [Google Scholar]
  11. doi: 10.1007/BF00919710. [DOI] [PubMed] [Google Scholar]
  12. doi: 10.1212/wnl.43.3_part_1.478. [DOI] [PubMed] [Google Scholar]
  13. doi: 10.1001/archneur.1993.00540060034013. [DOI] [PubMed] [Google Scholar]
  14. Chadwick D. Diagnosis of epilepsy. Lancet. 1990 Aug 4;336(8710):291–295. doi: 10.1016/0140-6736(90)91815-r. [DOI] [PubMed] [Google Scholar]
  15. Diagnosing juvenile myoclonic epilepsy. Lancet. 1992 Sep 26;340(8822):759–760. [PubMed] [Google Scholar]
  16. Greenberg D. A., Delgado-Escueta A. V., Widelitz H., Sparkes R. S., Treiman L., Maldonado H. M., Park M. S., Terasaki P. I. Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6. Am J Med Genet. 1988 Sep;31(1):185–192. doi: 10.1002/ajmg.1320310125. [DOI] [PubMed] [Google Scholar]
  17. Grünewald R. A., Chroni E., Panayiotopoulos C. P. Delayed diagnosis of juvenile myoclonic epilepsy. J Neurol Neurosurg Psychiatry. 1992 Jun;55(6):497–499. doi: 10.1136/jnnp.55.6.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Grünewald R. A., Panayiotopoulos C. P. Juvenile myoclonic epilepsy. A review. Arch Neurol. 1993 Jun;50(6):594–598. doi: 10.1001/archneur.1993.00540060034013. [DOI] [PubMed] [Google Scholar]
  19. Heller A. J., Chesterman P., Elwes R. D., Crawford P., Chadwick D., Johnson A. L., Reynolds E. H. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):44–50. doi: 10.1136/jnnp.58.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Jeavons P. M., Clark J. E., Maheshwari M. C. Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim"). Dev Med Child Neurol. 1977 Feb;19(1):9–25. doi: 10.1111/j.1469-8749.1977.tb08015.x. [DOI] [PubMed] [Google Scholar]
  21. Leppert M., Anderson V. E., Quattlebaum T., Stauffer D., O'Connell P., Nakamura Y., Lalouel J. M., White R. Benign familial neonatal convulsions linked to genetic markers on chromosome 20. Nature. 1989 Feb 16;337(6208):647–648. doi: 10.1038/337647a0. [DOI] [PubMed] [Google Scholar]
  22. Lewis T. B., Leach R. J., Ward K., O'Connell P., Ryan S. G. Genetic heterogeneity in benign familial neonatal convulsions: identification of a new locus on chromosome 8q. Am J Hum Genet. 1993 Sep;53(3):670–675. [PMC free article] [PubMed] [Google Scholar]
  23. Liporace J. D., Sperling M. R., Dichter M. A. Absence seizures and carbamazepine in adults. Epilepsia. 1994 Sep-Oct;35(5):1026–1028. doi: 10.1111/j.1528-1157.1994.tb02549.x. [DOI] [PubMed] [Google Scholar]
  24. Malafosse A., Lehesjoki A. E., Genton P., Labauge P., Durand G., Tassinari C. A., Dravet C., Michelucci R., de la Chapelle A. Identical genetic locus for Baltic and Mediterranean myoclonus. Lancet. 1992 May 2;339(8801):1080–1081. doi: 10.1016/0140-6736(92)90667-r. [DOI] [PubMed] [Google Scholar]
  25. Manonmani V., Wallace S. J. Epilepsy with myoclonic absences. Arch Dis Child. 1994 Apr;70(4):288–290. doi: 10.1136/adc.70.4.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Obeid T. Clinical and genetic aspects of juvenile absence epilepsy. J Neurol. 1994 Jul;241(8):487–491. doi: 10.1007/BF00919710. [DOI] [PubMed] [Google Scholar]
  27. doi: 10.1136/jnnp.56.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. doi: 10.1136/jnnp.55.6.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. doi: 10.1136/jnnp.55.11.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. doi: 10.1136/adc.70.4.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. doi: 10.1136/jnnp.57.6.682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. doi: 10.1136/jnnp.58.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Panayiotopoulos C. P. Benign childhood partial epilepsies: benign childhood seizure susceptibility syndromes. J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):2–5. doi: 10.1136/jnnp.56.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Panayiotopoulos C. P., Chroni E., Daskalopoulos C., Baker A., Rowlinson S., Walsh P. Typical absence seizures in adults: clinical, EEG, video-EEG findings and diagnostic/syndromic considerations. J Neurol Neurosurg Psychiatry. 1992 Nov;55(11):1002–1008. doi: 10.1136/jnnp.55.11.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Panayiotopoulos C. P., Obeid T., Waheed G. Differentiation of typical absence seizures in epileptic syndromes. A video EEG study of 224 seizures in 20 patients. Brain. 1989 Aug;112(Pt 4):1039–1056. doi: 10.1093/brain/112.4.1039. [DOI] [PubMed] [Google Scholar]
  36. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia. 1989 Jul-Aug;30(4):389–399. doi: 10.1111/j.1528-1157.1989.tb05316.x. [DOI] [PubMed] [Google Scholar]
  37. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia. 1981 Aug;22(4):489–501. doi: 10.1111/j.1528-1157.1981.tb06159.x. [DOI] [PubMed] [Google Scholar]
  38. Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure. First Seizure Trial Group (FIR.S.T. Group) Neurology. 1993 Mar;43(3 Pt 1):478–483. doi: 10.1212/wnl.43.3_part_1.478. [DOI] [PubMed] [Google Scholar]
  39. Richens A., Davidson D. L., Cartlidge N. E., Easter D. J. A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group. J Neurol Neurosurg Psychiatry. 1994 Jun;57(6):682–687. doi: 10.1136/jnnp.57.6.682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Verity C. M., Hosking G., Easter D. J. A multicentre comparative trial of sodium valproate and carbamazepine in paediatric epilepsy. The Paediatric EPITEG Collaborative Group. Dev Med Child Neurol. 1995 Feb;37(2):97–108. doi: 10.1111/j.1469-8749.1995.tb11978.x. [DOI] [PubMed] [Google Scholar]
  41. Whitehouse W. P., Rees M., Curtis D., Sundqvist A., Parker K., Chung E., Baralle D., Gardiner R. M. Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region. Am J Hum Genet. 1993 Sep;53(3):652–662. [PMC free article] [PubMed] [Google Scholar]

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