Abstract
Coxsackie B-1 virus was injected into the ear vein of albino doe rabbits. Saliva and blood samples were taken before the injection of virus and at specific times thereafter. Virus was recovered in the whole saliva when the blood titer was approximately 104 TCID50 per 0.1 ml or greater. The virus could be detected in the saliva as early as 2 min after the initiation of the viremia. The recovered virus was shown to be the same as the injected virus by serological identification of the recovered virus with neutralizing antibody for Coxsackie B-1 virus. These results suggest that virus may be transmitted to other animals in the saliva of animals who are in the viremic phase of infection without infection of the oropharyngeal tissues.
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Selected References
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- BODIAN D. Viremia in experimental poliomyelitis. I. General aspects of infection after intravascular inoculation with strains of high and of low invasiveness. Am J Hyg. 1954 Nov;60(3):339–357. [PubMed] [Google Scholar]
- KELLER R. Passage of bacteriophage particles through intact skin of mice. Science. 1958 Sep 26;128(3326):718–719. doi: 10.1126/science.128.3326.718-a. [DOI] [PubMed] [Google Scholar]
- SCHEIN A. H., TUNG F. Appearance of parenterally administered proteins in saliva. Nature. 1962 Dec 15;196:1092–1093. doi: 10.1038/1961092b0. [DOI] [PubMed] [Google Scholar]
- SCHULTZ I., FROHLICH E. VIRURIA AND VIRALIQUORIA IN THE DOG AFTER INTRAVENOUS INJECTION OF T5 BACTERIOPHAGE. Proc Soc Exp Biol Med. 1965 Jan;118:136–138. doi: 10.3181/00379727-118-29778. [DOI] [PubMed] [Google Scholar]
- UHR J. W., DANCIS J., FINKELSTEIN M. S. Passage of bacteriophage phi X 174 across the placenta in guinea pigs. Proc Soc Exp Biol Med. 1963 Jun;113:391–394. doi: 10.3181/00379727-113-28374. [DOI] [PubMed] [Google Scholar]