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. 1967 Nov;15(6):1409–1413. doi: 10.1128/am.15.6.1409-1413.1967

Production of Hyaluronic Acid by a Streptococcal Strain in Batch Culture

Björn Holmström 1, J Řičica 1,1
PMCID: PMC547214  PMID: 16349754

Abstract

A simple method for the production and preparation of hyaluronic acid (HA) is described. Three media were tested, which all supported relatively good yields of cells, but only in one of them were appreciable amounts of HA formed. In this medium, HA was produced during the logarithmic growth phase and showed a molecular weight of 7.3 × 105. HA prepared from 24-hr cultures of the same organism had a molecular weight of only 2.6 × 105. The kinetics of HA production in batch culture were studied, as well as of cell production and glucose consumption.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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