Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 Jan;27(1):192–196. doi: 10.1128/iai.27.1.192-196.1980

Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis.

E C Keystone, D Taylor-Robinson, M F Osborn, L Ling, C Pope, V Fornasier
PMCID: PMC550743  PMID: 6965663

Abstract

Mycoplasma pulmonis inoculated parenterally into athymic nude mice congenitally deficient in T cells caused a chronic arthritis of significantly greater magnitude than in immunologically normal mice. During the chronic phase of arthritis, M. pulmonis organisms were isolated from the joints and spleens of athymic nude mice more frequently and in larger numbers than from immunologically normal mice. The results support the concept that impaired T-cell function predisposes the mice to a severe degree of chronic arthritis as a result of their failure to eliminate the causative organisms.

Full text

PDF
195

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett J. C. The infectious etiology of rheumatoid arthritis. New considerations. Arthritis Rheum. 1978 Jun;21(5):531–538. doi: 10.1002/art.1780210507. [DOI] [PubMed] [Google Scholar]
  2. Cole B. C., Golightly-Rowland L., Ward J. R. Arthritis of mice induced by Mycoplasma pulmonis: humoral antibody and lymphocyte responses of CBA mice. Infect Immun. 1975 Nov;12(5):1083–1092. doi: 10.1128/iai.12.5.1083-1092.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Harwick H. J., Kalmanson G. M., Fox M. A., Guze L. B. Arthritis in mice due to infection with Mycoplasma pulmonis. I. Clinical and microbiologic features. J Infect Dis. 1973 Oct;128(4):533–540. doi: 10.1093/infdis/128.4.533. [DOI] [PubMed] [Google Scholar]
  4. Kaklamanis E., Pavlatos M. The immunosuppressive effect of mycoplasma infection. I. Effect on the humoral and cellular response. Immunology. 1972 Apr;22(4):695–702. [PMC free article] [PubMed] [Google Scholar]
  5. Pritchard H., Micklem H. S. Haemopoietic stem cells and progenitors of functional T-lymphocytes in the bone marrow of 'nude' mice. Clin Exp Immunol. 1973 Aug;14(4):597–607. [PMC free article] [PubMed] [Google Scholar]
  6. Raff M. C. Theta-bearing lymphocytes in nude mice. Nature. 1973 Dec 7;246(5432):350–351. doi: 10.1038/246350a0. [DOI] [PubMed] [Google Scholar]
  7. Scheid M. P., Goldstein G., Hammerling U., Boyse E. A. Lymphocyte differentiation from precursor cells in vitro. Ann N Y Acad Sci. 1975 Feb 28;249:531–540. doi: 10.1111/j.1749-6632.1975.tb29102.x. [DOI] [PubMed] [Google Scholar]
  8. Taylor-Robinson D., Purcell R. H., Wong D. C., Chanock R. M. A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production. J Hyg (Lond) 1966 Mar;64(1):91–104. doi: 10.1017/s0022172400040377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Taylor G., Taylor-Robinson D. Effects of active and passive immunization on Mycoplasma pulmonis-induced pneumonia in mice. Immunology. 1976 May;30(5):611–618. [PMC free article] [PubMed] [Google Scholar]
  10. Taylor G., Taylor-Robinson D., Keystone E. C. Effects of lymecycline on Mycoplasma pulmonis-induced arthritis in mice. Br J Exp Pathol. 1978 Apr;59(2):204–212. [PMC free article] [PubMed] [Google Scholar]
  11. Taylor G., Taylor-Robinson D., Slavin G. Effect of immunosuppression on arthritis in mice induced by Mycoplasma pulmonis. Ann Rheum Dis. 1974 Jul;33(4):376–384. doi: 10.1136/ard.33.4.376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wortis H. H. Immunological studies of nude mice. Contemp Top Immunobiol. 1974;3:243–263. doi: 10.1007/978-1-4684-3045-5_10. [DOI] [PubMed] [Google Scholar]
  13. Wortis H. H., Nehlsen S., Owen J. J. Abnormal development of the thymus in "nude" mice. J Exp Med. 1971 Sep 1;134(3 Pt 1):681–692. doi: 10.1084/jem.134.3.681. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES