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. 1980 Mar;27(3):969–978. doi: 10.1128/iai.27.3.969-978.1980

Fatal measles infection in marmosets pathogenesis and prophylaxis.

P Albrecht, D Lorenz, M J Klutch, J H Vickers, F A Ennis
PMCID: PMC550869  PMID: 6769812

Abstract

Moustached marmosets (Saguinus mystax) were infected intranasally with either of two low-passaged, wildlike strains of measles virus, strain Edmonston or strain JM. The infection resulted in 25 and 100% mortality, respectively, 12 to 14 days after infection. Clinical signs, gross pathological findings, and histology lacked the characteristic features of measles in other primates. A deficient immune response and widespread gastroenterocolitis appeared to be the main causes for the fatal outcome. Fluorescent-antibody staining detected large amounts of measles antigen in lymphatic tissues, the gastrointestinal and respiratory tracts, the salivary glands, pancreas, liver, kidney, and other visceral tissues. Live attenuated or inactivated measles vaccine proved equally effective in preventing fatal measles in marmosets. Challenge with live virus of animals which were primed 1 year previously with inactivated alum-absorbed vaccine resulted in a precipitous response, with a 100- to 1,000-fold increase in antibody titers. This vigorous booster response suggests the existence of a primary deficiency in lymphocyte cooperation in marmosets, which upon adequate priming is followed by extensive clonal expansion and antibody synthesis. Marmosets appear to be the most susceptible primate species to measles infection. They are capable of distinguishing differences in virulence of virus strains with a level of sensitivity not available in other animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Axton J. H. Measles: a protein-losing enteropathy. Br Med J. 1975 Jul 12;3(5975):79–80. doi: 10.1136/bmj.3.5975.79-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baer H., Lorenz D. The induction of immediate and delayed sensitivity in the marmoset. Proc Soc Exp Biol Med. 1970 Jun;134(2):410–412. doi: 10.3181/00379727-134-34802. [DOI] [PubMed] [Google Scholar]
  3. Burnet F. M. Measles as an index of immunological function. Lancet. 1968 Sep 14;2(7568):610–613. doi: 10.1016/s0140-6736(68)90701-0. [DOI] [PubMed] [Google Scholar]
  4. Corbett E. U. The Visceral Lesions in Measles: With a Report of Koplik Spots in the Colon. Am J Pathol. 1945 Sep;21(5):905–919. [PMC free article] [PubMed] [Google Scholar]
  5. Deinhardt F., Peterson D., Cross G., Wolfe L., Holmes A. W. Hepatitis in marmosets. Am J Med Sci. 1975 Jul-Aug;270(1):73–80. doi: 10.1097/00000441-197507000-00011. [DOI] [PubMed] [Google Scholar]
  6. Ebina T., Tsukamoto T., Suzuki H., Takase S., Itahara K., Ishida N. Measles virus in jejunum of patients with multiple sclerosis. Lancet. 1979 Jan;1(8107):99–99. doi: 10.1016/s0140-6736(79)90082-5. [DOI] [PubMed] [Google Scholar]
  7. Fireman P., Friday G., Kumate J. Effect of measles vaccine on immunologic responsiveness. Pediatrics. 1969 Feb;43(2):264–272. [PubMed] [Google Scholar]
  8. Fraser C. E., Chalifoux L., Sehgal P., Hunt R. D., King N. W. A paramyxovirus causing fatal gastroenterocolitis in marmoset monkeys. Primates Med. 1978;10:261–270. [PubMed] [Google Scholar]
  9. GIANNELLI F., CALVI A. M. [Hepatic function in measles. Study of 20 cases by means of some hepatic function tests]. Minerva Pediatr. 1961 Dec 8;13:1730–1737. [PubMed] [Google Scholar]
  10. Gengozian N., Kateley J. R., Nickerson D. A. Marmoset species variation in the humoral antibody response: in vivo and in vitro studies. Immunology. 1978 Sep;35(3):549–558. [PMC free article] [PubMed] [Google Scholar]
  11. Gengozian N., Salter B. L., Basford N. L., Kateley J. R. Characterization of the antibody response of the marmoset to sheep red blood cells. Clin Exp Immunol. 1976 Mar;23(3):525–535. [PMC free article] [PubMed] [Google Scholar]
  12. Greaves M., Janossy G. Elicitation of selective T and B lymphocyte responses by cell surface binding ligands. Transplant Rev. 1972;11:87–130. doi: 10.1111/j.1600-065x.1972.tb00047.x. [DOI] [PubMed] [Google Scholar]
  13. Hall W. C., Kovatch R. M., Herman P. H., Fox J. G. Pathology of measles in rhesus monkeys. Vet Pathol. 1971;8(4):307–319. doi: 10.1177/030098587100800403. [DOI] [PubMed] [Google Scholar]
  14. Harris R. W., Isacson P., Karzon D. T. Vaccine-induced hypersensitivity: reactions to live measles and mumps vaccine in prior recipients of inactivated measles vaccine. J Pediatr. 1969 Apr;74(4):552–563. doi: 10.1016/s0022-3476(69)80038-7. [DOI] [PubMed] [Google Scholar]
  15. Harvey J. S., Jr, Felsburg P. J., Heberling R. L., Kniker W. T., Kalter S. S. Immunological competence in non-human primates: differences observed in four species. Clin Exp Immunol. 1974 Feb;16(2):267–277. [PMC free article] [PubMed] [Google Scholar]
  16. Hicks J. T., Albrecht P. Cytolytic, complement-dependent antibodies to measles virus in rhesus monkeys after administration of live or killed virus. J Infect Dis. 1976 Jun;133(6):648–654. doi: 10.1093/infdis/133.6.648. [DOI] [PubMed] [Google Scholar]
  17. Hicks J. T., Sullivan J. L., Albrecht P. Immune responses during measles infection in immunosuppressed Rhesus monkeys. J Immunol. 1977 Oct;119(4):1452–1456. [PubMed] [Google Scholar]
  18. Hilleman M. R., Buynak E. B., Weibel R. E., Stokes J., Jr, Whitman J. E., Jr, Leagus M. B. Development and evaluation of the Moraten measles virus vaccine. JAMA. 1968 Oct 14;206(3):587–590. [PubMed] [Google Scholar]
  19. Hunt R. D., Anderson M. P., Chalifoux L. V. Spontaneous infectious diseases of marmosets. Primates Med. 1978;10:239–253. [PubMed] [Google Scholar]
  20. KEMPE C. H., FULGINITI V. A. THE PATHOGENESIS OF MEASLES VIRUS INFECTION. Arch Gesamte Virusforsch. 1965;16:103–128. doi: 10.1007/BF01253798. [DOI] [PubMed] [Google Scholar]
  21. Katz D. H., Benacerraf B. The regulatory influence of activated T cells on B cell responses to antigen. Adv Immunol. 1972;15:1–94. doi: 10.1016/s0065-2776(08)60683-5. [DOI] [PubMed] [Google Scholar]
  22. Levy B. M., Mirkovic R. R. An epizootic of measles in a marmoset colony. Lab Anim Sci. 1971 Feb;21(1):33–39. [PubMed] [Google Scholar]
  23. Morley D. C. Measles in the developing world. Proc R Soc Med. 1974 Nov;67(11):1112–1115. [PMC free article] [PubMed] [Google Scholar]
  24. Morley D. Severe measles in the tropics. I. Br Med J. 1969 Feb 1;1(5639):297–contd. doi: 10.1136/bmj.1.5639.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Payne F. E., Baublis J. V., Itabashi H. H. Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. N Engl J Med. 1969 Sep 11;281(11):585–589. doi: 10.1056/NEJM196909112811103. [DOI] [PubMed] [Google Scholar]
  26. Pertschuk L. P., Cook A. W., Gupta J. Measles antigen in multiple sclerosis: identification in the jejunum by immunofluorescence. Life Sci. 1976 Nov 15;19(10):1603–1608. doi: 10.1016/0024-3205(76)90107-7. [DOI] [PubMed] [Google Scholar]
  27. Peterson D. A., Wolfe L. G., Deinhardt F., Gajdusek D. C., Gibbs C. J., Jr Transmission of kuru and Creutzfeldt-Jakob disease to marmoset monkeys. Intervirology. 1974;2(1):14–19. doi: 10.1159/000149399. [DOI] [PubMed] [Google Scholar]
  28. Potkay S., Ganaway J. R., Rogers N. G., Kinard R. An epizootic of measles in a colony of rhesus monkeys (Macaca mulatta). Am J Vet Res. 1966 Jan;27(116):331–334. [PubMed] [Google Scholar]
  29. Prasad I., Broome J. D., Pertschuk L. P., Gupta J., Cook A. W. Recovery of Paramyxovirus from the jejunum of patients with multiple sclerosis. Lancet. 1977 May 28;1(8022):1117–1119. doi: 10.1016/s0140-6736(77)92381-9. [DOI] [PubMed] [Google Scholar]
  30. Wallen W. C., Claysmith A. P., Cicmanec J. L. Lymphocyte functions and subpopulation distribution in marmosets. Primates Med. 1978;10:184–192. [PubMed] [Google Scholar]
  31. Watson A. J., Parkin J. M. Jejunal-biopsy findings during prodromal stage of measles in a child with coeliac disease. Lancet. 1970 Nov 28;2(7683):1134–1135. doi: 10.1016/s0140-6736(70)92326-3. [DOI] [PubMed] [Google Scholar]
  32. Wolfe L. G., Deinhardt F. Overview of viral oncology studies in Saguinus and Callithrix species. Primates Med. 1978;10:96–118. [PubMed] [Google Scholar]
  33. Woyciechowska J. L., Madden D. L., Sever J. L. Absence of measles-virus antigen in jejunum of multiple-sclerosis patients. Lancet. 1977 Nov 19;2(8047):1046–1049. doi: 10.1016/s0140-6736(77)91881-5. [DOI] [PubMed] [Google Scholar]
  34. Yamanouchi K., Chino F., Kobune F., Kodama H., Tsuruhara T. Growth of measles virus in the lymphoid tissues of monkeys. J Infect Dis. 1973 Dec;128(6):795–799. doi: 10.1093/infdis/128.6.795. [DOI] [PubMed] [Google Scholar]

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