Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1980 Apr;28(1):286–289. doi: 10.1128/iai.28.1.286-289.1980

Isolation of enterochelin from the peritoneal washings of guinea pigs lethally infected with Escherichia coli.

E Griffiths, J Humphreys
PMCID: PMC550925  PMID: 6445881

Abstract

Escherichia coli secretes enterochelin while infecting normal guinea pigs. Since production of enterochelin is a well-characterized response to an iron-restricted environment, this work establishes that host iron-binding proteins do indeed influence the metabolism of the invading organism.

Full text

PDF
287

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bezkorovainy A., Zschocke R. H. Structure and function of transferrins. I. Physical, chemical, and iron-binding properties. Arzneimittelforschung. 1974 Apr;24(4):476–485. [PubMed] [Google Scholar]
  2. Bullen J. J., Rogers H. J., Griffiths E. Role of iron in bacterial infection. Curr Top Microbiol Immunol. 1978;80:1–35. doi: 10.1007/978-3-642-66956-9_1. [DOI] [PubMed] [Google Scholar]
  3. Bullen J. J., Ward C. G., Wallis S. N. Virulence and the role of iron in Pseudomonas aeruginosa infection. Infect Immun. 1974 Sep;10(3):443–450. doi: 10.1128/iai.10.3.443-450.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Garibaldi J. A. Influence of temperature on the biosynthesis of iron transport compounds by Salmonella typhimurium. J Bacteriol. 1972 Apr;110(1):262–265. doi: 10.1128/jb.110.1.262-265.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Grieger T. A., Kluger M. J. Fever and survival: the role of serum iron. J Physiol. 1978 Jun;279:187–196. doi: 10.1113/jphysiol.1978.sp012339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Griffiths E., Humphreys J. Alterations in tRNAs containing 2-methylthio-N6-(delta2-isopentenyl)-adenosine during growth of enteropathogenic Escherichia coli in the presence of iron-binding proteins. Eur J Biochem. 1978 Jan 16;82(2):503–513. doi: 10.1111/j.1432-1033.1978.tb12044.x. [DOI] [PubMed] [Google Scholar]
  7. Griffiths E., Humphreys J., Leach A., Scanlon L. Alterations in the tRNA's of Escherichia coli recovered from lethally infected animals. Infect Immun. 1978 Nov;22(2):312–317. doi: 10.1128/iai.22.2.312-317.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hancock R. E., Braun V. The colicin I receptor of Escherichia coli K-12 has a role in enterochelin-mediated iron transport. FEBS Lett. 1976 Jun 1;65(2):208–210. doi: 10.1016/0014-5793(76)80481-4. [DOI] [PubMed] [Google Scholar]
  9. Hollifield W. C., Jr, Neilands J. B. Ferric enterobactin transport system in Escherichia coli K-12. Extraction, assay, and specificity of the outer membrane receptor. Biochemistry. 1978 May 16;17(10):1922–1928. doi: 10.1021/bi00603a019. [DOI] [PubMed] [Google Scholar]
  10. Ichihara S., Mizushima S. Involvement of outer membrane proteins in enterochelin-mediated iron uptake in Escherichia coli. J Biochem. 1977 Mar;81(3):749–756. doi: 10.1093/oxfordjournals.jbchem.a131513. [DOI] [PubMed] [Google Scholar]
  11. Jones R. L., Peterson C. M., Grady R. W., Kumbaraci T., Cerami A., Graziano J. H. Effects of iron chelators and iron overload on Salmonella infection. Nature. 1977 May 5;267(5606):63–65. doi: 10.1038/267063a0. [DOI] [PubMed] [Google Scholar]
  12. Kluger M. J., Rothenburg B. A. Fever and reduced iron: their interaction as a host defense response to bacterial infection. Science. 1979 Jan 26;203(4378):374–376. doi: 10.1126/science.760197. [DOI] [PubMed] [Google Scholar]
  13. McIntosh M. A., Earhart C. F. Effect of iron of the relative abundance of two large polypeptides of the Escherichia coli outer membrane. Biochem Biophys Res Commun. 1976 May 3;70(1):315–322. doi: 10.1016/0006-291x(76)91144-x. [DOI] [PubMed] [Google Scholar]
  14. Pugsley A. P., Reeves P. Increased production of the outer membrane receptors for colicins B, D and M by Escherichia coli under iron starvation. Biochem Biophys Res Commun. 1976 Jun 7;70(3):846–853. doi: 10.1016/0006-291x(76)90669-0. [DOI] [PubMed] [Google Scholar]
  15. Rogers H. J. Iron-Binding Catechols and Virulence in Escherichia coli. Infect Immun. 1973 Mar;7(3):445–456. doi: 10.1128/iai.7.3.445-456.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rogers H. J., Synge C., Kimber B., Bayley P. M. Production of enterochelin by Escherichia coli 0111. Biochim Biophys Acta. 1977 Apr 27;497(2):548–557. doi: 10.1016/0304-4165(77)90211-2. [DOI] [PubMed] [Google Scholar]
  17. Weinberg E. D. Iron and infection. Microbiol Rev. 1978 Mar;42(1):45–66. doi: 10.1128/mr.42.1.45-66.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yancey R. J., Breeding S. A., Lankford C. E. Enterochelin (enterobactin): virulence factor for Salmonella typhimurium. Infect Immun. 1979 Apr;24(1):174–180. doi: 10.1128/iai.24.1.174-180.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES