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. 1980 May;28(2):594–600. doi: 10.1128/iai.28.2.594-600.1980

In vitro response of alveolar macrophages to infection with Coccidioides immitis.

L Beaman, C A Holmberg
PMCID: PMC550975  PMID: 6772563

Abstract

Alveolar macrophages obtained from rhesus macaques (Macaca mulatta) by bronchial lavage were observed to phagocytize endospores and arthrospores of Coccidioides immitis. When the macrophages were subsequently maintained in vitro, the phagocytized spores developed into spherules. There was no significant reduction in the viability of C. immitis after phagocytosis by macrophages from normal macaques, nor was killing induced by the addition of immune serum, complement, or lung lining material obtained from the bronchial lavage fluid. The inability of the macrophages to kill C. immitis may in part be explained by the observation that C. immitis appeared to inhibit fusion of the phagosomes containing the fungal spores with the lysosomes within the macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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