Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 May;28(2):624–626. doi: 10.1128/iai.28.2.624-626.1980

Muramyl dipeptide-induced adjuvant arthritis.

S Nagao, A Tanaka
PMCID: PMC550979  PMID: 7399679

Abstract

Muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine, induced adjuvant arthritis in WKA rats when injected in a water-in-oil emulsion prepared with Freund incomplete adjuvant (Difco), but not when emulsified with Drackeol and Arlacel A.

Full text

PDF
626

Images in this article

625Fig. 1
on p.625

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Audibert F., Heymer B., Gros C., Schleifer K. H., Seidl P. H., Chedid L. Absence of binding of MDP, a synthetic immunoadjuvant, to anti-peptidoglycan antibodies. J Immunol. 1978 Oct;121(4):1219–1222. [PubMed] [Google Scholar]
  2. Azuma I., Kanetsuna F., Kada Y., Takashima T., Yamamura Y. Adjuvant-polyarthritogenicity of cell walls of mycobacteria, nocardia and corynebacteria. Jpn J Microbiol. 1972 Jul;16(4):333–336. doi: 10.1111/j.1348-0421.1972.tb00666.x. [DOI] [PubMed] [Google Scholar]
  3. Berry H., Willoughby D. A., Giroud J. P. Evidence for an endogenous antigen in the adjuvant arthritic rat. J Pathol. 1973 Dec;111(4):229–238. doi: 10.1002/path.1711110403. [DOI] [PubMed] [Google Scholar]
  4. Chang Y. H., Pearson C. M. Pathogenesis of adjuvant arthritis in rats. Arthritis Rheum. 1978 Jan-Feb;21(1):169–170. doi: 10.1002/art.1780210133. [DOI] [PubMed] [Google Scholar]
  5. Emori K., Tanaka A. Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide. Infect Immun. 1978 Feb;19(2):613–620. doi: 10.1128/iai.19.2.613-620.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Koga T., Kotani S., Narita T., Pearson C. M. Induction of adjuvant arthritis in the rat by various bacterial cell walls and their water-soluble components. Int Arch Allergy Appl Immunol. 1976;51(2):206–213. doi: 10.1159/000231593. [DOI] [PubMed] [Google Scholar]
  7. Koga T., Maeda K., Onoue K., Kato K., Kotani S. Chemical structure required for immunoadjuvant and arthritogenic activities of cell wall peptidoglycans. Mol Immunol. 1979 Mar;16(3):153–162. doi: 10.1016/0161-5890(79)90140-8. [DOI] [PubMed] [Google Scholar]
  8. Koga T., Pearson C. M. Immunogenicity and arthritogenicity in the rat of an antigen from Mycobacterium tuberculosis wax D. J Immunol. 1973 Aug;111(2):599–608. [PubMed] [Google Scholar]
  9. Koga T., Pearson C. M., Narita T., Kotani S. Polyarthritis induced in the rat with cell walls from several bacteria and two Streptomyces species. Proc Soc Exp Biol Med. 1973 Jul;143(3):824–827. doi: 10.3181/00379727-143-37421. [DOI] [PubMed] [Google Scholar]
  10. Kohashi O., Pearson C. M., Watanabe Y., Kotani S., Koga T. Structural requirements for arthritogenicity of peptidoglycans from Staphylococcus aureus and Lactobacillus plant arum and analogous synthetic compounds. J Immunol. 1976 Jun;116(6):1635–1639. [PubMed] [Google Scholar]
  11. Kohashi O., Pearson C. M., Watanabe Y., Kotani S. Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. Infect Immun. 1977 Jun;16(3):861–866. doi: 10.1128/iai.16.3.861-866.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kohashi O., Pearson M., Beck F. J., Alexander M. Effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains. Infect Immun. 1977 Aug;17(2):244–249. doi: 10.1128/iai.17.2.244-249.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nagao S., Tanaka A., Yamamoto Y., Koga T., Onoue K., Shiba T., Kusumoto K., Kotani S. Inhibition of macrophage migration by muramyl peptides. Infect Immun. 1979 May;24(2):308–312. doi: 10.1128/iai.24.2.308-312.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. PEARSON C. M. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956 Jan;91(1):95–101. doi: 10.3181/00379727-91-22179. [DOI] [PubMed] [Google Scholar]
  15. PEARSON C. M., WOOD F. D. PASSIVE TRANSFER OF ADJUVANT ARTHRITIS BY LYMPH NODE OR SPLEEN CELLS. J Exp Med. 1964 Oct 1;120:547–560. doi: 10.1084/jem.120.4.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Paronetto F. Adjuvant arthritis induced by Corynebacterium rubrum. Proc Soc Exp Biol Med. 1970 Jan;133(1):296–298. doi: 10.3181/00379727-133-34459. [DOI] [PubMed] [Google Scholar]
  17. Quagliata F., Phillips-Quagliata J. M. Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease. Cell Immunol. 1972 Jan;3(1):78–87. doi: 10.1016/0008-8749(72)90228-6. [DOI] [PubMed] [Google Scholar]
  18. Staber F. G., Gisler R. H., Schumann G., Tarcsay L., Schläfli E., Dukor P. Modulation of myelopoiesis by different bacterial cell-wall components: induction of colony-stimulating activity (by pure preparations, low-molecular-weight degradation products, and a synthetic low-molecular analog of bacterial cell-wall components) in vitro. Cell Immunol. 1978 Apr;37(1):174–187. doi: 10.1016/0008-8749(78)90185-5. [DOI] [PubMed] [Google Scholar]
  19. Steffen C., Wick G. Delayed hypersensitivity reactions to collagen in rats with adjuvant-induced arthritis. Z Immunitatsforsch Allerg Klin Immunol. 1971;141(2):169–180. [PubMed] [Google Scholar]
  20. Tanaka A., Nagao S., Nagao R., Kotani S., Shiba T., Kusumoto S. Stimulation of the reticuloendothelial system of mice by muramyl dipeptide. Infect Immun. 1979 May;24(2):302–307. doi: 10.1128/iai.24.2.302-307.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Tanaka A., Saito R., Sugiyama K., Morisaki I., Kotani S. Adjuvant activity of synthetic N-acetylmuramyl peptides in rats. Infect Immun. 1977 Jan;15(1):332–334. doi: 10.1128/iai.15.1.332-334.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WAKSMAN B. H., PEARSON C. M., SHARP J. T. Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen. J Immunol. 1960 Oct;85:403–417. [PubMed] [Google Scholar]
  23. Whitehouse D. J., Whitehouse M. W., Pearson C. M. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature. 1969 Dec 27;224(5226):1322–1322. doi: 10.1038/2241322a0. [DOI] [PubMed] [Google Scholar]
  24. Whitehouse M. W., Orr K. J., Beck F. W., Pearson C. M. Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition. Immunology. 1974 Aug;27(2):311–330. [PMC free article] [PubMed] [Google Scholar]
  25. Wood F. D., Pearson C. M., Tanaka A. Capacity of mycobacterial wax D and its subfractions to induce adjuvant arthritis in rats. Int Arch Allergy Appl Immunol. 1969;35(5):456–467. doi: 10.1159/000230198. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES