Abstract
Mice that were fed a diet containing 400, 200 or 100 microgram of polychlorinated biphenyls (PCB) per g were significantly more susceptible to Herpes simplex virus than mice that were fed a PCB-free diet. The mortality of mice that were fed a diet containing 400 or 200 microgram of PCB per g and infected with ectromelia virus was higher than that of normal control mice infected with virus. There was no significant difference in inducibility of interferon by polyinosinic acid-polycytoidylic acid between PCB-fed mice and control mice.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Friend M., Trainer D. O. Polychlorinated biphenyl: interaction with duck hepatitis virus. Science. 1970 Dec 18;170(3964):1314–1316. doi: 10.1126/science.170.3964.1314. [DOI] [PubMed] [Google Scholar]
- Gainer J. H. Effects on interferon of heavy metal excess and zinc deficiency. Am J Vet Res. 1977 Jun;38(6):863–867. [PubMed] [Google Scholar]
- Koller L. D., Thigpen J. E. Biphenyl-exposed rabbits. Am J Vet Res. 1973 Dec;34(12):1605–1606. [PubMed] [Google Scholar]
- Loose L. D., Pittman K. A., Benitz K. F., Silkworth J. B. Polychlorinated biphenyl and hexachlorobenzene induced humoral immunosuppression. J Reticuloendothel Soc. 1977 Sep;22(3):253–271. [PubMed] [Google Scholar]
- Loose L. D., Silkworth J. B., Pittman K. A., Benitz K. F., Mueller W. Impaired host resistance to endotoxin and malaria in polychlorinated biphenyl- and hexachlorobenzene-treated mice. Infect Immun. 1978 Apr;20(1):30–35. doi: 10.1128/iai.20.1.30-35.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thomas P. T., Hinsdill R. D. Effect of polychlorinated biphenyls on the immune responses of rhesus monkeys and mice. Toxicol Appl Pharmacol. 1978 Apr;44(1):41–51. doi: 10.1016/0041-008x(78)90282-x. [DOI] [PubMed] [Google Scholar]
- Vos J. G., van Driel-Grootenhuis L. PCB-induced suppression of the humoral and cell-mediated immunity in guinea pigs. Sci Total Environ. 1972 Nov;1(3):289–302. doi: 10.1016/0048-9697(72)90024-1. [DOI] [PubMed] [Google Scholar]