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. 1980 Aug;29(2):408–410. doi: 10.1128/iai.29.2.408-410.1980

Immunity to pathogenic free-living amoebae: role of cell-mediated immunity.

R T Cursons, T J Brown, E A Keys, K M Moriarty, D Till
PMCID: PMC551133  PMID: 7011975

Abstract

The role of cell-mediated immunity in defense against pathogenic free-living amoebae was examined. Both the in vitro macrophage inhibition test and the in vivo delayed hypersensitivity test showed responses to both heterologous and homologous antigens, although homologous systems were the most efficient. It is suggested that exposure to nonpathogenic species of free-living amoebae can stimulate the immune system to be effective against pathogenic species. The significance of cell-mediated immunity as a defense against invasion by pathogenic free-living amoebae is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson K., Jamieson A. Agglutination test for the investigation of the genus Naegleria. Pathology. 1972 Oct;4(4):273–278. doi: 10.3109/00313027209068953. [DOI] [PubMed] [Google Scholar]
  2. Culbertson C. G., Ensminger P. W., Overton W. M. Amebic cellulocutaneous invasion by Naegleria aerobia with generalized visceral lesions after subcutaneous inoculation: an experimental study in guinea pigs. Am J Clin Pathol. 1972 Mar;57(3):375–386. doi: 10.1093/ajcp/57.3.375. [DOI] [PubMed] [Google Scholar]
  3. Culbertson C. G. The pathogenicity of soil amebas. Annu Rev Microbiol. 1971;25:231–254. doi: 10.1146/annurev.mi.25.100171.001311. [DOI] [PubMed] [Google Scholar]
  4. Cursons R. T., Brown T. J., Keys E. A., Moriarty K. M., Till D. Immunity to pathogenic free-living amoebae: role of humoral antibody. Infect Immun. 1980 Aug;29(2):401–407. doi: 10.1128/iai.29.2.401-407.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cursons R. T., Brown T. J. Use of cell cultures as an indicator of pathogenicity of free-living amoebae. J Clin Pathol. 1978 Jan;31(1):1–11. doi: 10.1136/jcp.31.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Diffley P., Skeels M. R., Sogandares-Bernal F. Delayed type hypersensitivity in guinea pig infected subcutaneously with Naegleria fowleri Carter. Z Parasitenkd. 1976 Apr 30;49(2):133–137. doi: 10.1007/BF00382420. [DOI] [PubMed] [Google Scholar]
  7. Fauci A. S. Mechanisms of the immunosuppressive and anti-inflammatory effects of glucocorticosteroids. J Immunopharmacol. 1978 1979;1(1):1–25. doi: 10.3109/08923977809027327. [DOI] [PubMed] [Google Scholar]
  8. Haggerty R. M., John D. T. Innate resistance of mice to experimental infection with Naegleria fowleri. Infect Immun. 1978 Apr;20(1):73–77. doi: 10.1128/iai.20.1.73-77.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. John D. T., Weik R. R., Adams A. C. Immunization of mice against Naegleria fowleri infection. Infect Immun. 1977 Jun;16(3):817–820. doi: 10.1128/iai.16.3.817-820.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Markowitz S. M., Sobieski T., Martinez A. J., Duma R. J. Experimental Acanthamoeba infections in mice pretreated with methylprednisolone or tetracycline. Am J Pathol. 1978 Sep;92(3):733–744. [PMC free article] [PubMed] [Google Scholar]
  11. Martínez A. J., Sotelo-Avila C., Garcia-Tamayo J., Morón J. T., Willaert E., Stamm W. P. Meningoencephalitis due to Acanthamoeba SP. Pathogenesis and clinico-pathological study. Acta Neuropathol. 1977 Mar 31;37(3):183–191. doi: 10.1007/BF00686877. [DOI] [PubMed] [Google Scholar]
  12. Thong Y. H., Shepherd C., Ferrante A., Rowan-Kelly B. Protective immunity to Naegleria fowleri in experimental amebic meningoencephalitis. Am J Trop Med Hyg. 1978 Mar;27(2 Pt 1):238–240. doi: 10.4269/ajtmh.1978.27.238. [DOI] [PubMed] [Google Scholar]
  13. Wong M. M., Karr S. L., Jr, Balamuth W. B. Experimental infections with pathogenic free-living amebae in laboratory primate hosts: I (A) A study on susceptibility to Naegleria fowleri. J Parasitol. 1975 Apr;61(2):199–208. [PubMed] [Google Scholar]
  14. Wong M. M., Karr S. L., Jr, Balamuth W. B. Experimental infections with pathogenic free-living amebae in laboratory primate hosts: I. (B) A study on susceptibility to Acanthamoeba culbertsoni. J Parasitol. 1975 Aug;61(4):682–690. [PubMed] [Google Scholar]

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