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. 1982 Jun;36(3):1123–1127. doi: 10.1128/iai.36.3.1123-1127.1982

Effect of cyclosporin A on murine natural killer cells.

X Gui, M Ho, P E Camp
PMCID: PMC551447  PMID: 6178687

Abstract

In mice, cyclosporin A decreased the natural killer cell-enhancing effect of two interferon inducers, infective murine cytomegalovirus and nonreplicating Newcastle disease virus. It also inhibited murine cytomegalovirus replication at doses greater than 20 mg/kg, but it did not significantly inhibit interferon induction by Newcastle disease virus. In cell culture, cyclosporin A had no direct effect on the natural killer activity of spleen mononuclear cells derived from normal or murine cytomegalovirus-infected animals. However, at 50 micrograms/ml it significantly reduced the ability of interferon to enhance the natural killer activity of normal spleen cell suspensions. The inhibitory effect of cyclosporin A on natural killer cell activity in infected mice may be partly explained by its ability to block the action of interferon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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