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. 1982 Jun;36(3):1246–1248. doi: 10.1128/iai.36.3.1246-1248.1982

Urinary virulence of Proteus mirabilis in two experimental mouse models.

P G Peerbooms, A Marian, J J Verweij, D M MacLaren
PMCID: PMC551464  PMID: 7047396

Abstract

Two experimental mouse models were tested for their suitability in measuring urinary virulence of Proteus mirabilis. In the first model, the kidney-infecting dose and lethal dose were measured. In the second model, the kinetics of the numbers of bacteria in the kidneys and other organs of the mouse were monitored for 13 h after injection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Larsson P., Olling S. 0 antigen distribution and sensitivity to the bactericidal effect of normal human serum of Proteus strains from clinical specimens. Med Microbiol Immunol. 1977 Jul 18;163(2):77–82. doi: 10.1007/BF02121822. [DOI] [PubMed] [Google Scholar]
  2. MacLaren D. M. The significance of urease in proteus pyelonephritis: a bacteriological study. J Pathol Bacteriol. 1968 Jul;96(1):45–56. doi: 10.1002/path.1700960106. [DOI] [PubMed] [Google Scholar]
  3. MacLaren D. M. The significance of urease in proteus pyelonephritis: a histological and biochemical study. J Pathol. 1969 Jan;97(1):43–49. doi: 10.1002/path.1710970107. [DOI] [PubMed] [Google Scholar]
  4. Maskell R., Pead L., Hallett R. J. Urinary pathogens in the male. Br J Urol. 1975 Dec;47(6):691–694. doi: 10.1111/j.1464-410x.1975.tb04041.x. [DOI] [PubMed] [Google Scholar]
  5. Musher D. M., Griffith D. P., Yawn D., Rossen R. D. Role of urease in pyelonephritis resulting from urinary tract infection with Proteus. J Infect Dis. 1975 Feb;131(2):177–181. doi: 10.1093/infdis/131.2.177. [DOI] [PubMed] [Google Scholar]
  6. Pazin G. J., Braude A. I. Immobilizing antibodies in urine. II. Prevention of ascending spread of Proteus mirabilis. Invest Urol. 1974 Sep;12(2):129–133. [PubMed] [Google Scholar]
  7. Saxena S. R., Bassett D. C. Sex-related incidence in proteus infection of the urinary tract in childhood. Arch Dis Child. 1975 Nov;50(11):899–901. doi: 10.1136/adc.50.11.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Senior B. W., Bradford N. C., Simpson D. S. The ureases of Proteus strains in relation to virulence for the urinary tract. J Med Microbiol. 1980 Nov;13(4):507–512. doi: 10.1099/00222615-13-4-507. [DOI] [PubMed] [Google Scholar]
  9. Silverblatt F. J. Host-parasite interaction in the rat renal pelvis: a possible role for pili in the pathogenesis of pyelonephritis. J Exp Med. 1974 Dec 1;140(6):1696–1711. doi: 10.1084/jem.140.6.1696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Stamm W. E., Martin S. M., Bennett J. V. Epidemiology of nosocomial infection due to Gram-negative bacilli: aspects relevant to development and use of vaccines. J Infect Dis. 1977 Aug;136 (Suppl):S151–S160. doi: 10.1093/infdis/136.supplement.s151. [DOI] [PubMed] [Google Scholar]
  11. van den Bosch J. F., de Graaff J., MacLaren D. M. Virulence of Escherichia coli in experimental hematogenous pyelonephritis in mice. Infect Immun. 1979 Jul;25(1):68–74. doi: 10.1128/iai.25.1.68-74.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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