Skip to main content
PMC home page
The EMBO Journal logoLink to The EMBO Journal
. 1982;1(4):427–431. doi: 10.1002/j.1460-2075.1982.tb01186.x

In vitro experiments on axon guidance demonstrating an anterior-posterior gradient on the tectum.

F Bonhoeffer, J Huf
PMCID: PMC553063  PMID: 6203734

Abstract

Axonal growth cones originating from explants of embryonic chick retina were simultaneously exposed to two different cell monolayers and their preference for particular monolayers as a substrate for growth was determined. These experiments show that: (1) nasal retinal axons can distinguish between retinal and tectal cells; (2) temporal retinal axons can distinguish between tectal cells that originated from different positions within the tectum along the antero-posterior axis; (3) axons originating from nasal parts of the retina have different recognizing capabilities from temporal axons; (4) the property of the tectal cells, which is attractive for temporal axons, has a graded distribution along the antero-posterior axis of the tectum; and (5) this gradient also exists in non-innervated tecta.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonhoeffer F., Huf J. Recognition of cell types by axonal growth cones in vitro. Nature. 1980 Nov 13;288(5787):162–164. doi: 10.1038/288162a0. [DOI] [PubMed] [Google Scholar]
  2. Cowan W. M., Martin A. H., Wenger E. Mitotic patterns in the optic tectum of the chick during normal development and after early removal of the optic vesicle. J Exp Zool. 1968 Sep;169(1):71–92. doi: 10.1002/jez.1401690110. [DOI] [PubMed] [Google Scholar]
  3. Fraser S. E. Differential adhesion approach to the patterning of nerve connections. Dev Biol. 1980 Oct;79(2):453–464. doi: 10.1016/0012-1606(80)90130-x. [DOI] [PubMed] [Google Scholar]
  4. Gierer A. Development of projections between areas of the nervous system. Biol Cybern. 1981;42(1):69–78. doi: 10.1007/BF00335161. [DOI] [PubMed] [Google Scholar]
  5. Gottlieb D. I., Glaser L. A novel assay of neuronal cell adhesion. Biochem Biophys Res Commun. 1975 Apr 7;63(3):815–821. doi: 10.1016/s0006-291x(75)80456-6. [DOI] [PubMed] [Google Scholar]
  6. Gottlieb D. I., Rock K., Glaser L. A gradient of adhesive specificity in developing avian retina. Proc Natl Acad Sci U S A. 1976 Feb;73(2):410–414. doi: 10.1073/pnas.73.2.410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Halfter W., Claviez M., Schwarz U. Preferential adhesion of tectal membranes to anterior embryonic chick retina neurites. Nature. 1981 Jul 2;292(5818):67–70. doi: 10.1038/292067a0. [DOI] [PubMed] [Google Scholar]
  8. LaVail J. H., Cowan W. M. The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development. Brain Res. 1971 May 21;28(3):391–419. doi: 10.1016/0006-8993(71)90053-9. [DOI] [PubMed] [Google Scholar]
  9. LaVail J. H., Cowan W. M. The development of the chick optic tectum. II. Autoradiographic studies. Brain Res. 1971 May 21;28(3):421–441. [PubMed] [Google Scholar]
  10. Letourneau P. C. Cell-to-substratum adhesion and guidance of axonal elongation. Dev Biol. 1975 May;44(1):92–101. doi: 10.1016/0012-1606(75)90379-6. [DOI] [PubMed] [Google Scholar]
  11. Rager G., von Oeynhausen B. Ingrowth and ramification of retinal fibers in the developing optic tectum of the chick embryo. Exp Brain Res. 1979 Apr 2;35(2):213–227. doi: 10.1007/BF00236612. [DOI] [PubMed] [Google Scholar]
  12. Trisler G. D., Schneider M. D., Nirenberg M. A topographic gradient of molecules in retina can be used to identify neuron position. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2145–2149. doi: 10.1073/pnas.78.4.2145. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The EMBO Journal are provided here courtesy of Nature Publishing Group

RESOURCES